Exploiting a geometrically sampled grid in the steered response power algorithm for localization improvement.

The steered response power phase transform (SRP-PHAT) is a beamformer method very attractive in acoustic localization applications due to its robustness in reverberant environments. This paper presents a spatial grid design procedure, called the geometrically sampled grid (GSG), which aims at computing the spatial grid by taking into account the discrete sampling of time difference of arrival (TDOA) functions and the desired spatial resolution. A SRP-PHAT localization algorithm based on the GSG method is also introduced. The proposed method exploits the intersections of the discrete hyperboloids representing the TDOA information domain of the sensor array, and projects the whole TDOA information on the space search grid. The GSG method thus allows one to design the sampled spatial grid which represents the best search grid for a given sensor array, it allows one to perform a sensitivity analysis of the array and to characterize its spatial localization accuracy, and it may assist the system designer in the reconfiguration of the array. Experimental results using both simulated data and real recordings show that the localization accuracy is substantially improved both for high and for low spatial resolution, and that it is closely related to the proposed power response sensitivity measure.

Epidemiological analysis on two decades of hospitalisations for meningitis in the United States.

Bacterial meningitis is an important source of mortality and morbidity worldwide. Data exist on specific vaccines against Streptococcus pneumoniae and Neisseria meningitidis indicating that they reduce the incidence of meningitis, yet comprehensive information on the trend of bacterial meningitis is still lacking. We analysed the Kids' Inpatient Database and the National Inpatient Database considering all bacterial meningitides in the United States, excluding cases of tuberculosis and sexually transmitted diseases. We analysed the trend of meningitis incidence from 1993 to 2011 and in specific age groups before and after the introduction of the pneumococcal conjugate vaccine 7 (PCV-7) and the meningococcal conjugate vaccine 4 (MCV-4). Moreover, we analysed the prevalence of aetiological agents to assess their changes. We estimated 295,706 cases of meningitis having occurred in the United States and a reduction of the discharge rate of 21 %. We observed a significant reduction in cases of meningitis in children and elderly patients following the introduction of the PCV-7. We also found a reduction in subjects aged 10-14 years, an age span consistent with the introduction of MCV-4, although further analyses based on serotypes data are required to confirm this observation. By contrast, we observed an increased prevalence of cases of staphylococcal and streptococcal meningitides. The introduction of PCV-7 has reduced the incidence and changed significantly the aetiology of bacterial meningitis in the United States during the last two decades.