Prevalence of clozapine-induced sialorrhea and its effect on quality of life.

RATIONALE: Clozapine has proven to be superior to other antipsychotic drugs in the treatment of schizophrenia but is under-prescribed due to its potentially severe side effects. Clozapine-induced sialorrhea (CIS) is a frequent and extremely uncomfortable side effect, which remains understudied. OBJECTIVES: To examine the prevalence of diurnal and nocturnal CIS in a sample of patients treated with clozapine, and to evaluate its impact on quality of life. METHODS: We conducted a cross-sectional, observational study of 130 patients with schizophrenia spectrum disorders treated with clozapine. The prevalence of CIS was evaluated via specific sialorrhea scales. None of the patients included in the study was receiving a specific treatment for hypersalivation during the study period. Possible associations between sialorrhea and clinical and quality of life variables were analyzed. RESULTS: Of 130 subjects, 120 (92.3%) suffered from CIS. Eighty-one (62.31%) suffered from diurnal CIS, 115 (88.56%) from nocturnal CIS, and 85 (65.38%) suffered from both. Significant positive associations between quality of life and diurnal CIS (B = 0.417; p = 2.1e - 6, R2 = 0.156) and nocturnal CIS (B = 0.411; p = 7.7e - 6, R2 = 0.139) were detected. Thirty per cent of the subjects reported a moderate to severe negative impact of sialorrhea on their quality of life. CONCLUSIONS: The present study suggests that CIS is highly prevalent in patients with schizophrenia and has an important impact on quality of life in one-third of our sample. Therefore, the inclusion of a systematic evaluation and treatment of CIS in standard clinical practice is highly recommended. TRIAL REGISTRATION: Clinical Trials ( https://clinicaltrials.gov ) under reference NCT04197037.

Prevalencia de actividad física en profesionales de atención primaria de Cataluña / Prevalence of physical activity in primary health care workers of Catalonia

Introducción. La inactividad física es el cuarto factor de riesgo respecto a la mortalidad mundial, y un porcentaje importante de la población mundial no realiza la actividad física necesaria para obtener beneficios para su salud. Determinados grupos profesionales son un ejemplo para la población general con la que interactúan. La prevalencia de actividad física en personal sanitario, uno de estos referentes, es en muchos casos desconocida. Nuestro objetivo ha sido identificar la prevalencia de los niveles de actividad física en profesionales sanitarios del ámbito de la atención primaria. Material y métodos. Se determinaron los niveles de actividad física en aquellos individuos del ámbito de la atención primaria que acudieron voluntariamente a efectuar reconocimiento médico durante el año 2014, mediante la aplicación de la versión corta del Cuestionario internacional de actividad física. Resultados. Un 26,5% de los individuos refirió un grado bajo de actividad física. El 31,5% de individuos del colectivo médico manifestó un nivel de actividad bajo, seguido del personal auxiliar (28,1%), el personal de enfermería (24,7%) y finalmente el personal de administración (19,0%). Conclusiones. Los niveles de actividad física del personal de atención primaria son sensiblemente distintos a los de la población general de referencia. En esta, el porcentaje de actividad física de intensidad leve y moderada es superior, siendo el nivel de actividad física de elevada intensidad inferior. Aunque parece existir una tendencia a valores sensiblemente inferiores de actividad física en otros colectivos sanitarios, no disponemos de datos suficientemente fiables para poder compararlos (AU)

Introduction. Physical inactivity is the fourth leading risk factor for global mortality, and a significant percentage of the world population does not perform the necessary physical activity for health benefits. Certain professional groups are seen as an example for the general population with whom they interact. Prevalence of physical activity in health workers, one of these reference groups, is mainly unknown. The aim of this study has been to assess the prevalence of physical activity levels in Primary Health Care professionals. Material and methods. A study was conducted on the physical activity levels in Primary Health Care workers who came voluntarily for a medical examination in 2014, and completed the short version of the International Physical Activity Questionnaire activity. Results. A low level of physical activity was reported by 26.5% of those taking part, with 31.5% of the medical group indicating a low level of activity, followed by support staff (28.1%), nurses (24.7%), and finally the administrative staff (19.0%). Conclusions. The physical activity levels of Primary Health Care staff are significantly different from those of the general reference population. The latter has a higher percentage of physical activity of mild to moderate intensity, and below the level of physical activity of high intensity. Although there seems to be a tendency to significantly lower physical activity in other health groups, we do not have sufficiently reliable data to compare them (AU)

[Prevalence of physical activity in primary health care workers of Catalonia]. / Prevalencia de actividad física en profesionales de atención primaria de Cataluña.

INTRODUCTION: Physical inactivity is the fourth leading risk factor for global mortality, and a significant percentage of the world population does not perform the necessary physical activity for health benefits. Certain professional groups are seen as an example for the general population with whom they interact. Prevalence of physical activity in health workers, one of these reference groups, is mainly unknown. The aim of this study has been to assess the prevalence of physical activity levels in Primary Health Care professionals. MATERIAL AND METHODS: A study was conducted on the physical activity levels in Primary Health Care workers who came voluntarily for a medical examination in 2014, and completed the short version of the International Physical Activity Questionnaire activity. RESULTS: A low level of physical activity was reported by 26.5% of those taking part, with 31.5% of the medical group indicating a low level of activity, followed by support staff (28.1%), nurses (24.7%), and finally the administrative staff (19.0%). CONCLUSIONS: The physical activity levels of Primary Health Care staff are significantly different from those of the general reference population. The latter has a higher percentage of physical activity of mild to moderate intensity, and below the level of physical activity of high intensity. Although there seems to be a tendency to significantly lower physical activity in other health groups, we do not have sufficiently reliable data to compare them.