RESUMEN
Thymomodulin and Thymolymphotropin, biologically active thymus derivative peptides exert recovery effects on the functionality of some membrane bound, mitochondrial and lysosomal enzymes (monoamine oxidase, ATPase, phosphatases, cytochrome oxidase, succinate oxidase) affected by gamma-irradiation. These drugs exert antistress effect by re-establishing the function of hypothalamus-pituitary-adrenal axis and that of lymphoid organs.
Asunto(s)
Sistemas Neurosecretores/efectos de la radiación , Estrés Fisiológico/fisiopatología , Extractos del Timo/farmacología , Animales , Encéfalo/enzimología , Encéfalo/patología , Encéfalo/efectos de la radiación , Membrana Celular/enzimología , Rayos gamma , Tejido Linfoide/enzimología , Tejido Linfoide/patología , Tejido Linfoide/efectos de la radiación , Lisosomas/enzimología , Masculino , Mitocondrias/enzimología , Monoaminooxidasa/metabolismo , Sistemas Neurosecretores/enzimología , Sistemas Neurosecretores/patología , Ratas , Ratas Wistar , Estrés Fisiológico/patologíaRESUMEN
Metronidazol, an efficient drug for Trichomonas vaginalis, Lamblia intestinalis and some anaerobic germs, administered in a daily dose of 500 mg/kg body weight for 60 and 40 days in males and females, respectively, produces severe structural alterations (atrophy and cytolysis, more apparent in the testicle) and elicits, a functional impairment as well (modifications in the activity of some enzymes: alkaline and acide-phosphatase, Mg(2+)-ATPase, CyOx, SDH, LDH). These morphological and histoenzymological changes in the steroidogenic formations suggest that Metronidazol severily affects the gametogenesis and hormonogenesis in rat.
Asunto(s)
Metronidazol/farmacología , Ovario/anatomía & histología , Testículo/anatomía & histología , Animales , Femenino , Masculino , Ovario/efectos de los fármacos , Ovario/enzimología , Ratas , Ratas Endogámicas , Testículo/efectos de los fármacos , Testículo/enzimologíaAsunto(s)
Intestino Delgado/efectos de los fármacos , Hígado/efectos de los fármacos , Procaína/administración & dosificación , Animales , Vías de Administración de Medicamentos , Femenino , Histocitoquímica , Intestino Delgado/enzimología , Intestino Delgado/patología , Hígado/enzimología , Hígado/patología , Ratas , Ratas Endogámicas , EstómagoRESUMEN
Some histological and histoenzymological changes of the small intestine of adult female Wistar rats treated with Madiol were studied. The steroid did not influence the tissular aspect, but obviously stimulatory effects on protein and enzyme reactions were induced. Similar Madiol-action on the small intestine of 21-day-old young rats was observed when the steroid was administered during pregnancy to their mothers, suggesting influences on the embryonic development.