RESUMEN
Brevibacteria are part of the normal flora of the skin and adjacent structures, but have been increasingly encountered in humans as opportunistic pathogens and have been isolated from various clinical specimens, generally causing infections in immuno-compromised patients. We present a case of a port-a-cath-related bacteraemia caused by Brevibacterium casei in a woman with a prior history of bilateral breast cancer. The clinical outcome was favourable.
Asunto(s)
Bacteriemia/microbiología , Brevibacterium/aislamiento & purificación , Infecciones Relacionadas con Catéteres/microbiología , Infección Hospitalaria/microbiología , Infecciones por Bacterias Grampositivas/microbiología , Infecciones Oportunistas/microbiología , Dispositivos de Acceso Vascular/microbiología , Antibacterianos/uso terapéutico , Bacteriemia/tratamiento farmacológico , Bacteriemia/etiología , Neoplasias de la Mama/terapia , Brevibacterium/efectos de los fármacos , Infecciones Relacionadas con Catéteres/tratamiento farmacológico , Infecciones Relacionadas con Catéteres/etiología , Terapia Combinada , Infección Hospitalaria/tratamiento farmacológico , Infección Hospitalaria/etiología , Remoción de Dispositivos , Contaminación de Equipos , Femenino , Infecciones por Bacterias Grampositivas/tratamiento farmacológico , Infecciones por Bacterias Grampositivas/etiología , Humanos , Linezolid/uso terapéutico , Persona de Mediana Edad , Neoplasias Primarias Múltiples/terapia , Infecciones Oportunistas/tratamiento farmacológico , Infecciones Oportunistas/etiología , Teicoplanina/uso terapéutico , Dispositivos de Acceso Vascular/efectos adversosRESUMEN
Dicrocoelium dendriticum is a liver parasite of ruminants. Humans are occasionally infected by ingestion of intermediate hosts. We report a rare case of dicrocoeliasis in a 55-year-old woman who presented with eosinophilia and elevated bilirubin. Therapy with albendazole eradicated the parasite and normalized blood parameters.
Asunto(s)
Dicroceliasis/parasitología , Dicrocoelium/patogenicidad , Albendazol/uso terapéutico , Animales , Antihelmínticos/uso terapéutico , Dicroceliasis/diagnóstico , Dicroceliasis/tratamiento farmacológico , Dicrocoelium/aislamiento & purificación , Heces/parasitología , Femenino , Humanos , Hallazgos Incidentales , Persona de Mediana EdadRESUMEN
Samples of atherosclerotic tissue from 58 patients undergoing carotid surgery were analysed by tissue culture and PCR for Chlamydia pneumoniae; PCR was performed to detect Omp1, 16S rRNA and HSP-70 genes. To understand the active pathogenic role of C. pneumoniae, a reverse transcriptase-PCR (RT-PCR) assay was applied to detect the specific RNAs expressed either in the replicative form, or in the cryptic form found in chronic infection. The C. pneumoniae omp1 gene, encoding the major outer-membrane protein (MOMP), was detected in 13 of 58 samples. Among these, the result was confirmed in 11 samples after amplification of a further target, the 16S rRNA, and the presence of the HSP-70 gene, encoding heat-shock protein 70, was revealed in only five cases. All the samples were negative for evidence of specific RNAs by RT-PCR. The presence of genomic DNA and absence of specific RNAs in atherosclerotic tissue samples suggests a lack of an active metabolic or persistent infective role for C. pneumoniae. Thus, traces of C. pneumoniae DNA in these samples could be due to a degradative pathway of the host defensive cellular and biochemical mechanisms.
