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1.
Int J Behav Dev ; 47(1): 21-34, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-36582414

RESUMEN

The frequency and length of games, conflicts, and contingency sequences that took place between toddlers as they got to know one another were studied using archival data. The sample consisted of 28 unfamiliar 20- and 30-month-old toddlers (predominantly White, 16 males) who met separately with each of two other toddlers for 18 play dates. The frequency of games increased over time, while the frequency of conflict and contingency sequences decreased. The length of games increased over time while the length of conflicts and contingency sequences were stable. Age and language ability predicted changes in frequency and length of the different types of sequences. Thus, toddlers engage in less structured interactions when they first meet; their interactions become increasingly more organized and positive as the relationship evolves.

2.
PLoS One ; 17(11): e0276932, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36327252

RESUMEN

Very little is known about the role of early interactions in the development of peer relationships among toddlers. The present study examined whether behaviors early in the formation of toddler relationships predict interactions later in their relationships. Twenty-eight unfamiliar 20- and 30-month-old toddlers from a predominately European background met separately with each of two other toddlers for 18 playdates. Both positive and negative behaviors at the beginning of the relationship predicted a higher frequency of games later in the relationship. Positive behaviors at the beginning of the relationship predicted fewer conflicts later in the relationship. Negative behaviors at the beginning predicted more conflicts later in the relationship. These findings suggest that toddlers' behaviors, when they initially meet, underlie the pathway in which their relationship develops.


Asunto(s)
Grupo Paritario , Humanos , Preescolar , Lactante
3.
J Vis Commun Med ; 44(2): 52-61, 2021 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-33866948

RESUMEN

Public stigma against mental illness is a barrier to treatment and recovery. Research into the design of anti-stigma messages has focused heavily on text; there is limited information on what types of images are most persuasive in eliciting anti-stigma outcomes. This is important to study because the type of image used to depict an illness can influence how the illness is perceived, which in turn can affect how people with the illness are treated. Through an online experiment with 162 American adults, this study investigated whether mental illness narratives about depression illustrated with photographs are more effective than those illustrated with cartoons at reducing stigma. It was found that the illustrated narratives, whether with photo or cartoon, produced more anti-stigma effects than the text-only narrative (control). Further, the photographic narrative was more effective than the cartoon narrative in eliciting closeness to the story protagonist and willingness to donate to mental health services. The study's findings indicate that images should be used in anti-stigma messages on depression; further, regarding image type, photographs should be considered over cartoons as they are more effective in eliciting certain anti-stigma outcomes.Implications for PracticeThis study suggests that images have strong anti-stigma effects and that photographs are sometimes more persuasive than cartoons. These findings can inform best-practice guidelines for designing anti-stigma messages, created and disseminated by organisations such as the United States' National Alliance on Mental Illness and Mental Health America. Images in these messages should be selected carefully as they can influence how people with mental illness are perceived and treated.


Asunto(s)
Trastornos Mentales , Estigma Social , Adulto , Humanos , Estados Unidos
4.
J Homosex ; 68(12): 2075-2096, 2021 Oct 15.
Artículo en Inglés | MEDLINE | ID: mdl-32130077

RESUMEN

Self-continuity, or how an individual understands their sense of self as persisting from past to present and present to future, is an important aspect of the self-concept that is linked to mental health outcomes. This self-concept construct may be particularly pertinent for sexual minority populations, as living in a heterosexist environment may prove detrimental for the development of self-continuity. The current study examined self-continuity among sexual minority and heterosexual community college and university students (N = 292). Compared to their heterosexual peers, sexual minority participants reported lower levels of self-continuity. Self-continuity moderated the associations between victimization due to gender nonconformity and victimization due to sexual minority status and depressive symptoms, such that higher levels of self-continuity were protective among individuals who were experiencing higher levels of victimization due to gender nonconformity or sexual minority status. Findings will be discussed in terms of their implications for identity development among emerging adults.


Asunto(s)
Acoso Escolar , Víctimas de Crimen , Minorías Sexuales y de Género , Adulto , Depresión , Heterosexualidad , Humanos
5.
Q J Exp Psychol (Hove) ; 73(11): 2036-2044, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-32564688

RESUMEN

In the present study, we analyse data from the English Lexicon Project to assess the extent to which age of acquisition (AoA) effects on word processing stem from the number of semantic associations tied to a word. We show that the backward number of associates (bNoA; that is, the log transformed number of words that produce the target word in free association) is an important predictor of both lexical decision and reading aloud performance, and reduces the typical AoA effect as represented by subject ratings in both tasks. Although the AoA effect is reduced, it remains a significant predictor of performance above and beyond bNoA. We conclude that the semantic locus of AoA effects can be found in the number of backward connections to the word, and that the independent AoA effect is due to network plasticity. We discuss how computational models currently explain AoA effects, and how bNoA may affect their processing.


Asunto(s)
Factores de Edad , Lectura , Semántica , Adolescente , Adulto , Niño , Preescolar , Humanos , Lactante , Recién Nacido , Modelos Psicológicos
6.
J Genet Psychol ; 180(4-5): 217-230, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31305235

RESUMEN

Hikikomori (social withdrawal that lasts six months or longer) is a growing problem among Japanese adolescents and young adults, with recent estimates that approximately 1% of Japanese youths will suffer from an episode of hikikomori in their lifetimes. What remains unclear is whether hikikomori is a culture-bound syndrome or a condition impacting youths around the globe. Hence, the self-reported prevalence and psychosocial correlates of past experiences with hikikomori were examined in cross-sectional samples of university students from Singapore (n = 147), Nigeria (n = 151), and the United States (n = 301). Following tests of measurement invariance, comparisons showed that past experiences with hikikomori were related to elevated levels of current loneliness and depressive symptoms in each sample. However, analyses also revealed evidence of cultural variation in both the prevalence and the psychosocial correlates associated with past experiences of hikikomori, which taken together, provide preliminary evidence that the culture-bound characterization of hikikomori may not be appropriate.


Asunto(s)
Depresión/epidemiología , Soledad/psicología , Carencia Psicosocial , Aislamiento Social/psicología , Estudiantes/psicología , Adolescente , Conducta del Adolescente/psicología , Desarrollo del Adolescente , Comparación Transcultural , Depresión/diagnóstico , Depresión/psicología , Femenino , Humanos , Masculino , Nigeria/epidemiología , Prevalencia , Autoinforme/estadística & datos numéricos , Singapur/epidemiología , Estudiantes/estadística & datos numéricos , Estados Unidos/epidemiología , Universidades , Adulto Joven
7.
J Abnorm Child Psychol ; 47(7): 1183-1195, 2019 07.
Artículo en Inglés | MEDLINE | ID: mdl-30714075

RESUMEN

Although numerous studies have established linkages between shyness and later psychological difficulties, most extant research did not examine variation in shyness over time in relation to variation in psychological difficulties over time or possible environmental factors of influence outside of the school context. The current study used multi-level modelling to simultaneously examine time-invariant and time-variant associations between shyness, the psychological difficulties of depressive symptoms and loneliness, and stressful life events at four waves across 1 year in a community sample of 271 young adolescents (51% boys; Mage = 11.83 years at W1). Results revealed significant time-variant and time-invariant effects when loneliness was examined as a predictor of shyness. In addition, a significant interaction effect indicated that shyness decreased over time for those young adolescents who experienced few stressful life events, highlighting an understudied moderator of risk. Overall, findings have important implications for understanding the psychological concomitants of shyness as well as etiological models of shyness.


Asunto(s)
Desarrollo del Adolescente , Depresión/psicología , Soledad/psicología , Timidez , Estrés Psicológico/psicología , Adolescente , Niño , Femenino , Humanos , Estudios Longitudinales , Masculino
8.
Clin Park Relat Disord ; 1: 13-20, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-34316593

RESUMEN

INTRODUCTION: Accurate early diagnosis of Parkinson's disease is hampered by its long prodromal period and the variable manifestations of its motor symptoms. While olfactory dysfunction can occur before motor-symptom onset and serve as a non-disease-specific diagnostic aid, its underlying causes are incompletely understood. METHODS: Correlation analyses, univariate density estimates, ANOVA and regression evaluated relationships between scores on the Montreal Cognitive Assessment and Hopkins Verbal Learning Test and those on the University of Pennsylvania Smell Identification Test in 1280 Parkinson's Progression Markers Initiative subjects placed into five diagnostic categories. Structural equation modeling identified cognitive measures having significant indirect effects on olfactory-function-test scores. RESULTS: Global cognition, verbal learning and memory, attention, delayed-recall, and visuospatial/executive function scores show weak-to-moderate, significant associations with olfactory-function-test scores. Associations are stronger in symptomatic than asymptomatic subjects having mutations in LRRK2, GBA or SNCA. Score distributions are nonuniform across diagnostic categories. Linear regression found that all cognitive measures except attention predicted olfactory-function-test scores. Three structural equation models assessing indirect effects of verbal learning/memory with either global cognition, visuospatial/executive function, or delayed-recall had a good statistical fit to the data. Only verbal learning/memory scores significantly help explain olfactory-function-test scores in all symptomatic diagnostic categories (-0.56 < b < -0.23, 0.001 < P < .005). Visuospatial/executive-function test scores help explain olfactory-function-test scores in both genetic Parkinson's disease diagnostic categories (-0.25 < b < -0.17, 0.032 < P < .033). CONCLUSION: Impaired verbal learning/memory and visuospatial/executive function contributes to lower performance on olfactory function tests in Parkinson's disease. As both of these domains impact decision-making, decision-making in turn may impact olfactory assessment in Parkinson's disease.

9.
Psicol. argum ; 36(93): 383-407, jul.-set. 2018. ilus, tab
Artículo en Inglés | Index Psicología - Revistas | ID: psi-72193

RESUMEN

Prosocial behaviors are correlated with positive relationships and acceptance by peers while aggression is correlated with negative relationships and rejection by peers. Peer aggression is also negatively correlated with peer liking, though the relationship may differ based on gender and norms. The current study examines the relationship between the different forms of aggression (physical, verbal, relational) and peer liking. The study asked 148 students from five classrooms in Curitiba, Brazil to complete peer nominations of their classmates and nominate students who were aggressive as well as rate how muchthey liked each peer. Multilevel modeling was used to analyze the data. Overall, girls were better liked than boys, and girls tended to like boys less than boys liked girls. Physical, verbal, and relational aggression all improved the overall model, and are important to understanding the full picture. Boys who were high in relational aggression liked other relationally aggressive boys less and girls who were less relationally aggressive liked more relationally aggressive girls less. Children high in physical aggression like physically aggressive peers more and this relationship was stronger for girls. In classrooms high in overall physical aggression, however, physically aggressive girls liked their physically aggressive peers less, indicating that context plays a key role. (AU)


Os comportamentos pró-sociais estão correlacionados com relacionamentos positivos e aceitação pelos pares, enquanto a agressão está correlacionada com relacionamentos negativos e rejeição pelos pares. A agressão de colegas também é negativamente correlacionada com o gosto de colegas, embora o relacionamento possa diferir com base no gênero e nas normas. O presente estudo examina a relação entre as diferentes formas de agressão (física, verbal, relacional) e o gosto dos colegas. O estudo solicitou a 148 alunos de cinco salas de aula em Curitiba, Brasil, que concluíssem as nomeações de colegas de turma e indicassem estudantes agressivos, além de avaliarem o quanto eles gostavam de cada colega. A modelagem multinível foi usada para analisar os dados. No geral, as meninas eram mais queridas que os meninos, e as meninas tendiam a gostar menos de meninos do que os meninos. A agressão física, verbal e relacional melhorou o modelo geral e é importante para entender a imagem completa. Garotos com alta agressão relacional gostavam menos de outros garotos relacionalmente agressivos e garotas menos agressivas com relacional gostavam menos de garotas relacionalmente agressivas. As crianças com alta agressão física gostam mais de colegas fisicamente agressivos e esse relacionamento era mais forte para as meninas. Nas salas de aula com alta agressão física geral, no entanto, as meninas fisicamente agressivas gostam menos de seus colegas fisicamente agressivos, indicando que o contexto desempenha um papel fundamental.(AU)


Asunto(s)
Humanos , Masculino , Femenino , Niño , Adolescente , Agresión , Ajuste Social , Conducta del Adolescente , Conducta Infantil , Identidad de Género , Psicología Social
10.
Sci Rep ; 8(1): 12114, 2018 08 14.
Artículo en Inglés | MEDLINE | ID: mdl-30108258

RESUMEN

Behavioral responses to novel situations often vary and can belong to a suite of correlated behaviors. Characteristic behaviors of different personality types (e.g. stress coping styles) are generally consistent across contexts and time. Here, we compare the repeatability and reliability of exploratory behaviors between zebrafish strains selectively bred to display contrasting behavioral responses to stressors that represent the proactive-reactive axis. Specifically, we measure exploratory behavior of individual fish in an open field test over five weeks. We quantified the stationary time, average swimming speed and time spent by a fish in the center area. We found a number of strain differences for each behavioral measure. Stationary time was the most repeatable and reliable measure for assessing proactive-reactive behavioral differences. Reactive zebrafish generally showed the highest reliability and repeatability of exploratory behavior compared to proactive zebrafish and a separate wild caught strain. Given the increased interest in the evolutionary consequences and proximate mechanisms of consistent individual differences, it will be important to continue to investigate how different selective pressures may influence expression of stress coping styles and their effects on the consistency of an animal's behavior.


Asunto(s)
Adaptación Fisiológica , Conducta Animal/fisiología , Conducta Exploratoria/fisiología , Individualidad , Pez Cebra/fisiología , Animales , Animales de Laboratorio/fisiología , Animales Salvajes/fisiología , Técnicas de Observación Conductual , Femenino , Masculino , Estrés Fisiológico/fisiología
11.
J Res Adolesc ; 28(4): 875-887, 2018 12.
Artículo en Inglés | MEDLINE | ID: mdl-29388361

RESUMEN

Two longitudinal studies conducted with early adolescents (ages 10-13) examined the hypothesis that self-continuity, or the degree to which individuals feel that they remain the same person over time regardless of how their specific characteristics may change, would moderate the association between victimization and depressed affect. Both Study 1 (N = 141) and Study 2 (N = 100) provided evidence of the moderating role of self-continuity as a buffer on the effect of peer victimization. Study 2 confirmed that self-continuity had a moderating effect after controlling for academic performance, number of friends, self-esteem, self-concept clarity, hopelessness, and self-blame. Findings support self-continuity as being protective with regard to negative peer environments.


Asunto(s)
Víctimas de Crimen/psicología , Depresión/psicología , Éxito Académico , Adolescente , Niño , Depresión/etiología , Femenino , Humanos , Estudios Longitudinales , Masculino , Grupo Paritario , Autoimagen
12.
Mem Cognit ; 45(4): 589-599, 2017 05.
Artículo en Inglés | MEDLINE | ID: mdl-28211025

RESUMEN

We tested the list homogeneity effect in reading aloud (e.g., Lupker, Brown, & Colombo, 1997) using a megastudy paradigm. In each of two conditions, we used 25 blocks of 100 trials. In the random condition, words were selected randomly for each block, whereas in the experimental condition, words were blocked by difficulty (e.g., easy words together, etc.), but the order of the blocks was randomized. We predicted that standard factors (e.g., frequency) would be more predictive of reaction times (RTs) in the blocked than in the random condition, because the range of RTs across the experiment would increase in the blocked condition. Indeed, we found that the standard deviations and ranges of RTs were larger in the blocked than in the random condition. In addition, an examination of items at the difficulty extremes (i.e., very easy vs. very difficult) demonstrated a response bias. In regression analyses, a predictor set of seven sublexical, lexical, and semantic variables accounted for 2.8% more RT variance (and 2.6% more zRT variance) in the blocked than in the random condition. These results indicate that response deadlines apply to megastudies of reading aloud, and that the influence of predictors may be underestimated in megastudies when item presentation is randomized. In addition, the CDP++ model accounted for 0.8% more variance in RTs (1.2% in zRTs) in the blocked than in the random condition. Thus, computational models may have more predictive power on item sets blocked by difficulty than on those presented in random order. The results also indicate that models of word processing need to accommodate response criterion shifts.


Asunto(s)
Tiempo de Reacción/fisiología , Lectura , Proyectos de Investigación , Habla/fisiología , Adolescente , Adulto , Femenino , Humanos , Masculino , Factores de Tiempo , Adulto Joven
13.
Am J Primatol ; 79(2): 1-12, 2017 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-27643386

RESUMEN

The timing of reproductive maturation is susceptible to hormonal and environmental influences, and variation in this timing can be partially attributed to the prenatal and post-natal environment. We examined associations between prenatal steroid exposure and the post-natal family environment on the variability in reproductive maturation timing in young marmosets (Callithrix geoffroyi). Urine samples from pregnant females were analyzed for cortisol (CORT) and androgens (uA). Post-natal uA was measured in males to determine age (in days) of adult-like levels of androgens associated with spermatogenesis; post-natal pregnanediol glucuronide (PdG) was measured in females to determine age (in days) of first ovulation. Maternal, paternal, alloparental, and total care (carrying, grooming, and rejection/removals) of offspring were observed. Female offspring exposed to lower prenatal uA levels and higher paternal grooming and lower maternal rejection/removals showed later first ovulation, whereas female offspring exposed to higher prenatal uA showed earlier first ovulation. Male offspring showed earlier reproductive maturation as paternal grooming increased, regardless of first trimester uA exposure. Male offspring exposed to low prenatal uA levels showed earlier reproductive maturation as maternal rejections/removals increased. In offspring exposed to low prenatal CORT, high total carrying predicted earlier first ovulation in females, but later reproductive maturation in males. Total carrying duration did not affect timing of reproductive maturation in offspring exposed to high third trimester CORT levels. Our findings expand the evolutionary theory of socialization by demonstrating that the effect of post-natal family environment on timing of reproductive maturation depends on prenatal uA exposure and also influences reproductive maturation timing in male offspring.


Asunto(s)
Andrógenos/fisiología , Callithrix/crecimiento & desarrollo , Reproducción , Animales , Conducta Animal , Femenino , Hidrocortisona , Masculino , Ovulación , Embarazo , Espermatogénesis
14.
Rehabil Psychol ; 62(1): 20-24, 2017 02.
Artículo en Inglés | MEDLINE | ID: mdl-27918176

RESUMEN

OBJECTIVE: Depression is more common among persons with multiple sclerosis (MS) than the general population. Depression in MS is associated with reduced quality of life, transition to unemployment, and cognitive impairment. Two proposed screening measures for depression in MS populations are the Hospital Anxiety and Depression Scale (HADS) and the Beck Depression Inventory-Fast Screen (BDI-FS). Our objective was to compared the associations of the BDI-FS and the HADS-D scores with history of depressive symptoms, fatigue, and functional outcomes to determine the differential clinical utility of these screening measures among persons with MS. METHOD: We reviewed charts of 133 persons with MS for demographic information; scores on the HADS, BDI-FS, a fatigue measure, and a processing speed measure; and employment status. RESULTS: Structural equation modeling results indicated the HADS-D predicted employment status, disability status, and processing speed more effectively than did the BDI-FS, whereas both measures predicted fatigue. CONCLUSIONS: This study suggests the HADS-D is more effective than the BDI-FS in predicting functional outcomes known to be associated with depression among persons with MS. (PsycINFO Database Record


Asunto(s)
Trastorno Depresivo/diagnóstico , Trastorno Depresivo/psicología , Tamizaje Masivo/métodos , Esclerosis Múltiple/psicología , Adolescente , Adulto , Trastornos del Conocimiento/epidemiología , Trastornos del Conocimiento/psicología , Trastornos del Conocimiento/rehabilitación , Estudios Transversales , Trastorno Depresivo/epidemiología , Trastorno Depresivo/rehabilitación , Evaluación de la Discapacidad , Fatiga/epidemiología , Fatiga/psicología , Fatiga/rehabilitación , Femenino , Humanos , Masculino , Persona de Mediana Edad , Esclerosis Múltiple/epidemiología , Esclerosis Múltiple/rehabilitación , Inventario de Personalidad/estadística & datos numéricos , Pronóstico , Psicometría/estadística & datos numéricos , Calidad de Vida/psicología , Tiempo de Reacción , Rehabilitación Vocacional/psicología , Encuestas y Cuestionarios , Adulto Joven
15.
J Clin Child Adolesc Psychol ; 46(6): 798-809, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-26673014

RESUMEN

A two-wave longitudinal study of 380 preadolescents (M age = 10.87) from largely middle-class schools in Montréal, Québec, Canada, assessed the hypothesis that friendship security, but not friendship intimacy, moderates the stability of anxiety during adolescence. This central but largely overlooked question about peer relations concerns which aspects of friendship account for the effects of friendship on emotional adjustment. Anxiety and friendship quality were measured via self-report questionnaires, employing the Network of Relationships Inventory for security and intimacy items. An index of friendship durability, which combined reciprocity and stability within first- and second-best friendship choices, was derived from sociometric measures. A latent variable path analysis examined with structural equation modeling showed that anxiety was less stable for children who perceived their friendships as secure. The moderating effect of intimacy was statistically nonsignificant. A follow-up analysis showed that the effects of security did not result from friendship durability. These findings provide support for the long-standing but previously unaddressed hypothesis that security, rather than intimacy, accounts for friendship's effect on anxiety reduction during early adolescence.


Asunto(s)
Ansiedad/psicología , Amigos/psicología , Relaciones Interpersonales , Niño , Femenino , Humanos , Estudios Longitudinales , Masculino , Apoyo Social , Encuestas y Cuestionarios
16.
Q J Exp Psychol (Hove) ; 68(8): 1711-22, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-25312702

RESUMEN

To examine megastudy context effects, 585 critical words, each with a different orthographic rime, were placed at the beginning or end of a 2614-word megastudy of reading aloud. Sixty participants (30 participants in each condition) responded to these words. Specific predictors examined for change between beginning and end conditions were frequency, length, feedforward rime consistency, feedforward onset consistency, orthographic neighbourhood size, age of acquisition (AoA), and imageability. While it took longer to respond to items at the end of the experiment than items at the beginning of the experiment, there was very little change in the effects of the specific variables assessed. Thus, there is little evidence of list context effects influencing the estimates of the predictor variables in large-scale megastudies.


Asunto(s)
Conjuntos de Datos como Asunto , Lectura , Semántica , Habla , Adolescente , Adulto , Fatiga , Femenino , Humanos , Imaginación , Modelos Logísticos , Masculino , Fonética , Estimulación Luminosa , Tiempo de Reacción/fisiología , Disposición en Psicología , Vocabulario , Adulto Joven
17.
Psychoneuroendocrinology ; 38(7): 997-1006, 2013 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-23131593

RESUMEN

Despite a large body of research in non-human primates, the relationship between naturalistic patterns of social behaviour and basal cortisol levels has been understudied in humans. The present study examined the relationship between patterns of interpersonal functioning and cortisol levels in 23 offspring of parents with bipolar disorder (BD), at high risk for the development of an affective disorder, and 22 offspring of parents with no affective disorder (controls) in late adolescence and young adulthood. Using event-contingent recording, participants rated their dominance, submissiveness, quarrelsomeness, and agreeableness in naturally occurring social interactions over 14 consecutive days and provided salivary cortisol twice daily in the afternoon over the same period. In the full sample, multilevel modelling analyses revealed that dominance was a significant positive predictor of afternoon basal cortisol levels, t(35)=2.58, p<0.05. Moreover, risk group (having a parent with BD or parents with no affective disorder) significantly interacted with mean levels of quarrelsomeness to predict afternoon cortisol levels, t(29)=2.06, p<0.05. Offspring of parents with BD who reported more frequent quarrelsome behaviours exhibited lower levels of afternoon cortisol relative to high-risk offspring reporting few quarrelsome behaviours and control offspring. The results are consistent with evidence that dominance is associated with high cortisol levels in an unstable environment, and suggest that quarrelsomeness among high risk youth contributes to altered hypothalamic-pituitary-adrenal activity.


Asunto(s)
Trastorno Bipolar , Hijo de Padres Discapacitados/psicología , Hidrocortisona/análisis , Relaciones Interpersonales , Adolescente , Adulto , Femenino , Humanos , Masculino , Factores de Riesgo , Saliva/química
18.
Gen Comp Endocrinol ; 175(3): 519-26, 2012 Feb 01.
Artículo en Inglés | MEDLINE | ID: mdl-22212825

RESUMEN

High levels of prenatal cortisol have been previously reported to retard fetal growth. Although cortisol plays a pivotal role in prenatal maturation, heightened exposure to cortisol can result in lower body weights at birth, which have been shown to be associated with adult diseases like hypertension and cardiovascular disease. This study examines the relationship between natural variation in gestational cortisol and fetal and postnatal growth in marmoset monkeys. Urinary samples obtained during the mother's gestation were analyzed for cortisol. Marmoset body mass index (BMI) was measured from birth through 540 days in 30- or 60-day intervals. Multi-level modeling was used to test if marmoset growth over time was predicted by changes in gestational cortisol controlling for time, sex, litter, and litter size. The results show that offspring exposed to intra-uterine environments with elevated levels of cortisol had lower linear BMI rates of change shortly after birth than did offspring exposed to lower levels of cortisol, but exhibited a higher curvilinear growth rate during adolescence. Average daily change in gestational cortisol during the first trimester had a stronger relationship with postnatal growth than change during the third trimester. Higher exposure to cortisol during gestation does alter developmental trajectories, however there appears to be a catch-up period during later post-natal growth. These observations contribute to a larger discussion about the relationship of maternal glucocorticoids on offspring development and the possibility of an earlier vulnerable developmental window.


Asunto(s)
Animales Recién Nacidos/crecimiento & desarrollo , Callithrix/metabolismo , Desarrollo Fetal/fisiología , Hidrocortisona/orina , Preñez/orina , Animales , Biomarcadores/orina , Índice de Masa Corporal , Femenino , Masculino , Valor Predictivo de las Pruebas , Embarazo , Efectos Tardíos de la Exposición Prenatal/fisiopatología
19.
Bipolar Disord ; 12(1): 77-86, 2010 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-20148869

RESUMEN

OBJECTIVES: The hypothalamic-pituitary-adrenal (HPA) axis is compromised in major depression, bipolar disorder (BD), and in the offspring of parents with major depression. Less is known about the offspring of parents with BD (FH+). The present project provides follow-up to a previous study showing that the adolescent (mean age 16.7 years) FH+ offspring had higher salivary cortisol levels than the offspring of parents with no mental disorder (FH-) throughout the day in their natural environment, and that girls had higher cortisol levels than boys (Ellenbogen MA, Hodgins S, Walker C-D, Adam S, Couture S. Daytime cortisol and stress reactivity in the offspring of parents with bipolar disorder. Psychoneuroendocrinology 2006; 31: 1164-1180). The goal of the present study was to determine whether FH+ offspring, approximately two years later, continued to exhibit elevated cortisol levels relative to FH- offspring during two weeks of daily sampling. METHODS: The present study examined salivary cortisol levels in 24 (18.3 +/- 2.6 years) FH+ and 22 (18.0 +/- 2.3 years) FH- offspring who are part of the same longitudinal cohort as the previous study. Saliva was collected at 1300 h and 1500 h in the natural environment of the offspring during 14 consecutive days. RESULTS: Multilevel modelling analyses indicated that FH+ offspring had higher afternoon levels of cortisol in their natural environment than FH- offspring, but group differences in slope and gender differences were not found. CONCLUSIONS: The FH+ offspring exhibited increased daytime secretion of cortisol that, at the level of the group, persisted into late adolescence and young adulthood. Perhaps this change in HPA functioning is associated with an increased vulnerability for the development of an affective disorder.


Asunto(s)
Trastorno Bipolar/genética , Hijo de Padres Discapacitados , Hidrocortisona/metabolismo , Saliva/química , Adolescente , Adulto , Ritmo Circadiano/fisiología , Femenino , Estudios de Seguimiento , Humanos , Masculino , Medición de Riesgo , Encuestas y Cuestionarios , Adulto Joven
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