FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial.

Excessive gestational weight gain (GWG) is associated with increased risk of maternal and neonatal complications. We investigated obesity-related polymorphisms in the FTO gene (rs9939609, rs17817449) and ADRB2 (rs1042713, rs1042714) as candidate risk factors concerning excessive GWG in pregnant women with pregestational diabetes. This nutrigenetic trial, conducted in Brazil, randomly assigned 70 pregnant women to one of the groups: traditional diet (n = 41) or DASH diet (n = 29). Excessive GWG was the total weight gain above the upper limit of the recommendation, according to the Institute of Medicine guidelines. Genotyping was performed using real-time PCR. Time-to-event analysis was performed to investigate risk factors for progression to excessive GWG. Regardless the type of diet, AT carriers of rs9939609 (FTO) and AA carriers of rs1042713 (ADRB2) had higher risk of earlier exceeding GWG compared to TT (aHR 2.44; CI 95% 1.03-5.78; p = 0.04) and GG (aHR 3.91; CI 95% 1.12-13.70; p = 0.03) genotypes, respectively, as the AG carriers for FTO haplotype rs9939609:rs17817449 compared to TT carriers (aHR 1.79; CI 95% 1.04-3.06; p = 0.02).

A gestante e o processo de viver com diabetes mellitus / The pregnant woman and the process of living with diabetes mellitus

Resumo Introdução Gestação está associada à vida e saúde, mas pode acompanhar algum processo de adoecimento, como é o caso do diabetes mellitus, na condição prévia (tipo 1 ou 2) ou gestacional. Compreender a vivência dessas gestantes pode instrumentalizar para a construção de uma proposta de atenção pré-natal especializada e humanizada. Objetivo interpretar os sentidos e significados da gestação com diabetes, sob a perspectiva de mulheres no ciclo gravídico-puerperal. Métodos Estudo de natureza qualitativa com o objetivo de retratar o processo de viver com diabetes mellitus (DM) na gestação, sob a perspectiva das gestantes. Participaram 17 puérperas adultas, com diagnóstico de DM prévio ou gestacional, que realizaram o pré-natal e tiveram seus filhos em uma maternidade pública do Rio de Janeiro. Foram adotadas as técnicas de observação sistemática, bem como entrevistas semiestruturadas e levantamento de dados de prontuário institucional. A interpretação dos dados foi realizada por meio de uma aproximação com o referencial da hermenêutica de profundidade, com adaptação de suas fases, utilizando-se da análise de conteúdo temática, adaptada de Bardin. Resultados Foram identificadas duas categorias, extraídas do corpus das entrevistas: (1) refém do diabetes, relacionando o DM a situações irreversíveis que comprometem a qualidade de vida; e (2) doença da vigilância, associando o DM ao conjunto de medidas terapêuticas necessárias ao seu gerenciamento, como restrição e privação alimentares. Conclusão Concluiu-se que o processo de gestar com DM é permeado por sentidos que merecem ser compreendidos, pois exercem influências sobre o autocuidado e o desfecho da gestação.

Abstract Background Pregnancy is associated with life and health, but it can accompany some illness process, such as diabetes melittus, in the previous (type 1 or 2) or gestational condition. Understanding the experience of these pregnant women can provide instruments for the construction of a proposal for specialized and humanized prenatal care. Objective to interpret the senses and meanings of pregnancy with diabetes, from the perspective of women in the pregnancy-puerperal cycle. Method A qualitative study aimed to bring forward the process of living with diabetes mellitus (DM) during pregnancy, from the perspective of pregnant women. Participants were 17 postpartum women, diagnosed with DM and who underwent prenatal care and had their children in public maternity in Rio de Janeiro. The techniques of systematic observation, semi-structured interviews, and data collection of institutional records were adopted. The interpretation of the data was carried out using an approximation with the reference of the Depth Hermeneutics, with an adaptation of its phases, using Thematic Content Analysis, adapted from Bardin. Results Two categories were identified, extracted from the interview corpus: (1) diabetes hostage, linking DM to irreversible situations that impair quality of life, and (2) disease of surveillance, associating DM with the therapeutic measures necessary for its management, as food restriction and deprivation. Conclusion It was concluded that the process of gestation with DM is permeated by senses, which deserve to be understood since they exert influence on self-care and the outcome of gestation.

Pregestational excess weight and adverse maternal outcomes: a systematic review of previous studies in Brazil / Exceso de peso pregestacional y resultados maternos adversos: una revisión sistemática de estudios previos en Brasil

INTRODUCTION: obesity is increasing among women at reproductive age in Brazil. Excess body weight during pregnancy negatively impacts women's health. OBJECTIVES: to identify and analyze the publications that showed the effects of pregestational excess weight on pregnancy, delivery, and post-delivery in Brazilian women. METHODS: this systematic review was performed including studies that involve Brazilian pregnant women with adverse outcomes caused by pregestational excess weight. Search, selection, and reporting were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The study was conducted by manually searching and screening the databases LILACS, PubMed, Scopus, Cochrane, and Periodicos CAPES. The selected articles were evaluated according to the quality of evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE), and categorized as studies with high (A), moderate (B), low (C), or extremely low (D) evidence quality. RESULTS: a total of 1,582 studies were found, of which 39 were included for final reading and evaluation. Among these, 12.8 %, 69.2 %, and 18.0 % were classified as A, B, and C or D for evidence quality, respectively. Hypertensive disorders of pregnancy, caesarean section, excessive weight gain, and gestational diabetes mellitus were commonly associated with pregestational excess weight in Brazilian women. CONCLUSIONS: the negative effects of excess body weight during pregnancy reflect the need for effective public policies that can address the problem, focusing on interventions that promote the health of women at reproductive age

INTRODUCCIÓN: la obesidad está aumentando entre las mujeres en edad reproductiva en Brasil. El exceso de peso corporal durante el embarazo afecta negativamente a la salud de las mujeres. OBJETIVOS: identificar y analizar publicaciones que mostraran los efectos del exceso de peso pregestacional sobre el embarazo, el parto y el posparto en mujeres brasileñas. MÉTODOS: esta revisión sistemática incluye estudios de mujeres embarazadas brasileñas con resultados adversos causados por el exceso de peso pregestacional. La búsqueda, la selección y la presentación de los resultados se realizaron de acuerdo con el sistema Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). El estudio se realizó mediante la búsqueda manual y el cribado de las bases de datos LILACS, PubMed, Scopus, Cochrane y Periódicos CAPES. Los artículos seleccionados se evaluaron de acuerdo con la calidad de la evidencia utilizando el sistema Grading of Recommendations, Assessment, Development and Evaluation (GRADE), y se clasificaron como estudios de alta (A), moderada (B), baja (C) o extremadamente baja (D) calidad de la evidencia. RESULTADOS: se encontraron un total de 1582 estudios, de los cuales 39 se incluyeron para su lectura final y evaluación. Entre estos, el 12,8 %, 69,2 % y 18,0 % se clasificaron como A, B y C o D en cuanto a calidad de evidencia, respectivamente. Los trastornos hipertensivos del embarazo, la cesárea, el aumento de peso excesivo y la diabetes mellitus gestacional se asociaron comúnmente con el exceso de peso pregestacional en las mujeres brasileñas. CONCLUSIONES: los efectos negativos del exceso de peso corporal durante el embarazo reflejan la necesidad de políticas públicas efectivas que puedan abordar el problema, centrándose en intervenciones que promuevan la salud de las mujeres en edad reproductiva

Pregestational excess weight and adverse maternal outcomes: a systematic review of previous studies in Brazil.

INTRODUCTION: Introduction: obesity is increasing among women at reproductive age in Brazil. Excess body weight during pregnancy negatively impacts women's health. Objetives: to identify and analyze the publications that showed the effects of pregestational excess weight on pregnancy, delivery, and post-delivery in Brazilian women. Methods: this systematic review was performed including studies that involve Brazilian pregnant women with adverse outcomes caused by pregestational excess weight. Search, selection, and reporting were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The study was conducted by manually searching and screening the databases LILACS, PubMed, Scopus, Cochrane, and Periodicos CAPES. The selected articles were evaluated according to the quality of evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE), and categorized as studies with high (A), moderate (B), low (C), or extremely low (D) evidence quality. Results: a total of 1,582 studies were found, of which 39 were included for final reading and evaluation. Among these, 12.8%, 69.2%, and 18.0% were classified as A, B, and C or D for evidence quality, respectively. Hypertensive disorders of pregnancy, caesarean section, excessive weight gain, and gestational diabetes mellitus were commonly associated with pregestational excess weight in Brazilian women. Conclusions: the negative effects of excess body weight during pregnancy reflect the need for effective public policies that can address the problem, focusing on interventions that promote the health of women at reproductive age.

INTRODUCCIÓN: Introducción: la obesidad está aumentando entre las mujeres en edad reproductiva en Brasil. El exceso de peso corporal durante el embarazo afecta negativamente a la salud de las mujeres. Objetivos: identificar y analizar publicaciones que mostraran los efectos del exceso de peso pregestacional sobre el embarazo, el parto y el posparto en mujeres brasileñas. Métodos: esta revisión sistemática incluye estudios de mujeres embarazadas brasileñas con resultados adversos causados por el exceso de peso pregestacional. La búsqueda, la selección y la presentación de los resultados se realizaron de acuerdo con el sistema Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). El estudio se realizó mediante la búsqueda manual y el cribado de las bases de datos LILACS, PubMed, Scopus, Cochrane y Periódicos CAPES. Los artículos seleccionados se evaluaron de acuerdo con la calidad de la evidencia utilizando el sistema Grading of Recommendations, Assessment, Development and Evaluation (GRADE), y se clasificaron como estudios de alta (A), moderada (B), baja (C) o extremadamente baja (D) calidad de la evidencia. Resultados: se encontraron un total de 1582 estudios, de los cuales 39 se incluyeron para su lectura final y evaluación. Entre estos, el 12,8%, 69,2% y 18,0% se clasificaron como A, B y C o D en cuanto a calidad de evidencia, respectivamente. Los trastornos hipertensivos del embarazo, la cesárea, el aumento de peso excesivo y la diabetes mellitus gestacional se asociaron comúnmente con el exceso de peso pregestacional en las mujeres brasileñas. Conclusiones: los efectos negativos del exceso de peso corporal durante el embarazo reflejan la necesidad de políticas públicas efectivas que puedan abordar el problema, centrándose en intervenciones que promuevan la salud de las mujeres en edad reproductiva.

A pilot intervention to reduce postpartum weight retention at primary health care in Brazil / Una intervención piloto para reducir la retención de peso después del parto en la atención primaria de salud en Brasil

Background: postpartum weight retention (PWR) strongly predicts obesity, the major nutritional concern of this century; however, there is a gap in nutritional care for postpartum women in Brazil. Objective: to evaluate the effect of nutritional counselling provided at primary health care on the reduction of PWR. Method: pilot study carried out in a low-income community in southeastern Brazil, involving postpartum women with PWR, who were provided with individual monthly appointments with a nutritionist over three months of follow-up. Nutritional counselling was based on the Dietary Approach to Stop Hypertension (DASH diet) aiming at healthy and gradual weight loss. Anthropometric evaluation included measurement of weight, height, waist circumference and percentage of body fat. Dietary intake was assessed using a food frequency questionnaire and adherence to diet was evaluated using a DASH score. Results: women who participated in the study (n = 26) showed a reduction in PWR (median -1.80 kg, p = 0.004), body mass index (-0.57 kg/m², p = 0.004), and waist circumference (-2.50 cm, p = 0.024), as well as 91.67% of them presented good adherence to diet. Conclusion: nutritional counselling provided to low-income postpartum women at primary health care contributed to the reduction of PWR, body mass index and waist circumference, as the study participants presented good adherence to a healthy dietary pattern

Introducción: la retención de peso después del parto (RPDP) predice firmemente la obesidad, que es la principal preocupación nutricional de este siglo; sin embargo, existe una brecha en la atención nutricional para las mujeres después del parto en Brasil. Objetivo: evaluar el efecto del asesoramiento nutricional brindado en Atención Primaria sanitaria sobre la reducción de RPDP. Método: estudio piloto realizado en una comunidad de bajos ingresos en el sureste de Brasil, en el que participaron mujeres postparto con RPDP, que recibieron citas mensuales individuales con un nutricionista durante tres meses de seguimiento. El asesoramiento nutricional se basó en la dieta Dietary Approach to Stop Hypertension (DASH) y apuntó a una pérdida de peso saludable y gradual. La evaluación antropométrica incluyó la medición del peso, la altura, la circunferencia de la cintura y el porcentaje de grasa corporal. La ingesta dietética se evaluó mediante un cuestionario de frecuencia alimentaria y la adherencia a la dieta se evaluó mediante un score DASH. Resultados: las mujeres que participaron en el estudio (n = 26) mostraron una reducción en la RPDP (mediana de -1,80 kg, p = 0,004), índice de masa corporal (-0,57 kg/m², p = 0,004) y circunferencia de la cintura (-2,50 cm, p = 0,024); el 91.67% de ellas presentaron buena adherencia a la dieta. Conclusión: el asesoramiento nutricional brindado a las mujeres de bajos ingresos después del parto en Atención Primaria sanitaria contribuyó a la reducción de la RPDP, el índice de masa corporal y la circunferencia de la cintura, ya que los participantes del estudio presentaron una buena adherencia a un patrón de dieta saludable

A pilot intervention to reduce postpartum weight retention at primary health care in Brazil.

INTRODUCTION: Background: postpartum weight retention (PWR) strongly predicts obesity, the major nutritional concern of this century; however, there is a gap in nutritional care for postpartum women in Brazil. Objective: to evaluate the effect of nutritional counselling provided at primary health care on the reduction of PWR. Method: pilot study carried out in a low-income community in southeastern Brazil, involving postpartum women with PWR, who were provided with individual monthly appointments with a nutritionist over three months of follow-up. Nutritional counselling was based on the Dietary Approach to Stop Hypertension (DASH diet) aiming at healthy and gradual weight loss. Anthropometric evaluation included measurement of weight, height, waist circumference and percentage of body fat. Dietary intake was assessed using a food frequency questionnaire and adherence to diet was evaluated using a DASH score. Results: women who participated in the study (n = 26) showed a reduction in PWR (median -1.80 kg, p = 0.004), body mass index (-0.57 kg/m², p = 0.004), and waist circumference (-2.50 cm, p = 0.024), as well as 91.67% of them presented good adherence to diet. Conclusion: nutritional counselling provided to low-income postpartum women at primary health care contributed to the reduction of PWR, body mass index and waist circumference, as the study participants presented good adherence to a healthy dietary pattern.

INTRODUCCIÓN: Introducción: la retención de peso después del parto (RPDP) predice firmemente la obesidad, que es la principal preocupación nutricional de este siglo; sin embargo, existe una brecha en la atención nutricional para las mujeres después del parto en Brasil. Objetivo: evaluar el efecto del asesoramiento nutricional brindado en Atención Primaria sanitaria sobre la reducción de RPDP. Método: estudio piloto realizado en una comunidad de bajos ingresos en el sureste de Brasil, en el que participaron mujeres postparto con RPDP, que recibieron citas mensuales individuales con un nutricionista durante tres meses de seguimiento. El asesoramiento nutricional se basó en la dieta Dietary Approach to Stop Hypertension (DASH) y apuntó a una pérdida de peso saludable y gradual. La evaluación antropométrica incluyó la medición del peso, la altura, la circunferencia de la cintura y el porcentaje de grasa corporal. La ingesta dietética se evaluó mediante un cuestionario de frecuencia alimentaria y la adherencia a la dieta se evaluó mediante un score DASH. Resultados: las mujeres que participaron en el estudio (n = 26) mostraron una reducción en la RPDP (mediana de -1,80 kg, p = 0,004), índice de masa corporal (-0,57 kg/m², p = 0,004) y circunferencia de la cintura (-2,50 cm, p = 0,024); el 91.67% de ellas presentaron buena adherencia a la dieta. Conclusión: el asesoramiento nutricional brindado a las mujeres de bajos ingresos después del parto en Atención Primaria sanitaria contribuyó a la reducción de la RPDP, el índice de masa corporal y la circunferencia de la cintura, ya que los participantes del estudio presentaron una buena adherencia a un patrón de dieta saludable.

Adaptation of DASH diet (Dietary Approach to Stop Hypertension) for postpartum nutritional care at primary healthcare. / Adaptação da dieta DASH (Dietary Approaches to Stop Hypertension) para cuidado nutricional no período pós-parto, no âmbito da Atenção Básica.

INTRODUCTION: Postpartum weight retention has been found to predict obesity. However, in Brazil, there's no national strategy for nutritional care of postpartum woman. OBJECTIVE: This study aimed to adapt DASH diet (Dietary Approaches to Stop Hypertension) for nutritional counseling of postpartum woman, at primary healthcare. METHOD: Methodological study, carried out in 2016, at low-income urban neighborhood in the city of Rio de Janeiro. It was developed in four steps: translation, food and food groups adaptation, identification of geographic and economic access to food and viability evaluation. RESULTS: The food groups of original diet were structured to Brazilian dietary pattern. After viability analysis, it was observed that the geographical access of food should be accounted to enable greater adherence. A qualitative and illustrated meal plan was elaborated for nutritional counseling. CONCLUSION: The adapted DASH diet for nutritional care of postpartum woman seems to be according to the Brazilian dietary pattern, maintaining nutritional characteristics that provide the health benefits previously demonstrated. Currently, it's being used in interventional study in two primary healthcare unities at the city of Rio de Janeiro.

INTRODUÇÃO: A retenção de peso pós-parto é fator preditor para desenvolvimento de obesidade. Entretanto, não existe um protocolo para o cuidado nutricional de mulheres no período pós-parto, no Brasil. OBJETIVO: Este estudo teve por objetivo adaptar a dieta Dietary Approaches to Stop Hypertension (DASH) para orientação nutricional de mulheres no período pós-parto, no âmbito da Atenção Básica. MÉTODO: Estudo metodológico, desenvolvido em 2016, em uma comunidade do Rio de Janeiro. Foi constituído de quatro etapas: tradução, adaptação dos alimentos e grupos alimentares, identificação de acessibilidade geográfica e financeira e avaliação da viabilidade. RESULTADOS: Os grupos de alimentos da dieta original foram estruturados para o padrão brasileiro de consumo. Após avaliação da viabilidade da proposta, observou-se que a orientação deve ser direcionada de forma compatível com a realidade local, para que seja possibilitada maior adesão. Para orientação nutricional, foi elaborado um plano alimentar qualitativo e ilustrado. CONCLUSÃO: A adaptação da dieta DASH para cuidado nutricional de mulheres no período pós-parto parece estar de acordo com o padrão alimentar brasileiro, mantendo as características nutricionais que lhe imputam os benefícios à saúde previamente estudados. Atualmente, está sendo utilizada em estudo de intervenção realizado em dois Serviços de Atenção Básica do município do Rio de Janeiro.

Adaptação da dieta DASH (Dietary Approaches to Stop Hypertension) para cuidado nutricional no período pós-parto, no âmbito da Atenção Básica / Adaptation of DASH diet (Dietary Approach to Stop Hypertension) for postpartum nutritional care at primary healthcare

Resumo: Introdução: A retenção de peso pós-parto é fator preditor para desenvolvimento de obesidade. Entretanto, não existe um protocolo para o cuidado nutricional de mulheres no período pós-parto, no Brasil. Objetivo: Este estudo teve por objetivo adaptar a dieta Dietary Approaches to Stop Hypertension (DASH) para orientação nutricional de mulheres no período pós-parto, no âmbito da Atenção Básica. Método: Estudo metodológico, desenvolvido em 2016, em uma comunidade do Rio de Janeiro. Foi constituído de quatro etapas: tradução, adaptação dos alimentos e grupos alimentares, identificação de acessibilidade geográfica e financeira e avaliação da viabilidade. Resultados: Os grupos de alimentos da dieta original foram estruturados para o padrão brasileiro de consumo. Após avaliação da viabilidade da proposta, observou-se que a orientação deve ser direcionada de forma compatível com a realidade local, para que seja possibilitada maior adesão. Para orientação nutricional, foi elaborado um plano alimentar qualitativo e ilustrado. Conclusão: A adaptação da dieta DASH para cuidado nutricional de mulheres no período pós-parto parece estar de acordo com o padrão alimentar brasileiro, mantendo as características nutricionais que lhe imputam os benefícios à saúde previamente estudados. Atualmente, está sendo utilizada em estudo de intervenção realizado em dois Serviços de Atenção Básica do município do Rio de Janeiro.

ABSTRACT: Introduction: Postpartum weight retention has been found to predict obesity. However, in Brazil, there's no national strategy for nutritional care of postpartum woman. Objective: This study aimed to adapt DASH diet (Dietary Approaches to Stop Hypertension) for nutritional counseling of postpartum woman, at primary healthcare. Method: Methodological study, carried out in 2016, at low-income urban neighborhood in the city of Rio de Janeiro. It was developed in four steps: translation, food and food groups adaptation, identification of geographic and economic access to food and viability evaluation. Results: The food groups of original diet were structured to Brazilian dietary pattern. After viability analysis, it was observed that the geographical access of food should be accounted to enable greater adherence. A qualitative and illustrated meal plan was elaborated for nutritional counseling. Conclusion: The adapted DASH diet for nutritional care of postpartum woman seems to be according to the Brazilian dietary pattern, maintaining nutritional characteristics that provide the health benefits previously demonstrated. Currently, it's being used in interventional study in two primary healthcare unities at the city of Rio de Janeiro.

Intake of oral photoprotectors by postmen in Porto Alegre

Introduction: Postmen are daily exposed to high levels of solar radiation, and lack of protection can result in many health damages. The present study aimed to identify cutaneous phototypes and evaluate the intake of oral photoprotectors by postmen. Methods: Cross-sectional study, carried out from August 2011 to December 2012 in the city of Porto Alegre, state of Rio Grande do Sul, Brazil. Socioeconomic and behavioral data regarding daily solar exposure were collected through a questionnaire. To evaluate the intake of beta-carotene, lycopene and omega-3, two 24-hour dietary recalls were applied. Cutaneous phototypes were assessed by Fitzpatrick's classification. Results: A total of 181 postmen were analyzed, whose mean age was 40.2±11.4 years old, and 140 (77.3%) were male. The cutaneous phototypes II, III and IV were the most prevalent (n=138), totaling 76.3% of the sample. The median for the oral photoprotectors intake was 1.16 mg (0.46-2.29) of beta-carotene, 3.60 mg (1.01-6.31) of lycopene and 0.95 g (0.61-1.45) of n-3 fatty acids, all values significantly lower than the minimal doses to obtain photoprotective effect (p<0.001). The individuals in the group of phototypes V and VI showed lower adherence to the use of sunscreen and lower intake of beta-carotene, comparing to the other groups. Conclusions: The intake of oral photoprotectors is low in this population. Future studies may evaluate the real effect of oral photoprotectors, so that preventive measures using this approach can be included in photoprotection education actions for outdoor workers (AU)