Asunto(s)
Neoplasias del Mediastino/genética , Mutación , Paraganglioma Extraadrenal/genética , Succinato Deshidrogenasa/genética , Femenino , Predisposición Genética a la Enfermedad , Herencia , Humanos , Neoplasias del Mediastino/diagnóstico por imagen , Neoplasias del Mediastino/patología , Neoplasias del Mediastino/cirugía , Persona de Mediana Edad , Paraganglioma Extraadrenal/diagnóstico por imagen , Paraganglioma Extraadrenal/patología , Paraganglioma Extraadrenal/cirugía , Linaje , Esternotomía , Resultado del TratamientoAsunto(s)
Adenocarcinoma in Situ/complicaciones , Adenocarcinoma del Pulmón/complicaciones , Malformación Adenomatoide Quística Congénita del Pulmón/complicaciones , Neoplasias Pulmonares/complicaciones , Adenocarcinoma in Situ/genética , Adenocarcinoma in Situ/patología , Adenocarcinoma in Situ/cirugía , Adenocarcinoma del Pulmón/genética , Adenocarcinoma del Pulmón/patología , Adenocarcinoma del Pulmón/cirugía , Adulto , Biomarcadores de Tumor/genética , Malformación Adenomatoide Quística Congénita del Pulmón/diagnóstico , Humanos , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/patología , Neoplasias Pulmonares/cirugía , Masculino , Mutación Missense , Neumonectomía , Proteínas Proto-Oncogénicas p21(ras)/genética , Resultado del TratamientoRESUMEN
Rosai-Dorfman disease or sinus histiocytosis is a nonmalignant disease chiefly presenting as a painless cervical lymphadenopathy, although extranodal involvement is also frequent. Involvement of the tracheobronchial tree is extremely rare, and there are no clear guidelines on management. Rosai-Dorfman disease usually presents as a tracheal tumor, although it may also present with extraluminal compression. Only 12 cases have been reported in the English language literature. Histopathology is required to confirm the diagnosis. We describe what we think is India's first reported case of histologically proven tracheal Rosai-Dorfman disease in a 40-year-old otherwise healthy lady.
Asunto(s)
Histiocitos/patología , Histiocitosis Sinusal/patología , Enfermedades de la Tráquea/patología , Adulto , Biomarcadores/análisis , Biopsia , Broncoscopía , Femenino , Histiocitos/química , Histiocitosis Sinusal/diagnóstico por imagen , Histiocitosis Sinusal/cirugía , Humanos , Inmunohistoquímica , Proteínas S100/análisis , Enfermedades de la Tráquea/diagnóstico por imagen , Enfermedades de la Tráquea/cirugía , Resultado del TratamientoRESUMEN
Pulmonary dirofilariasis, caused by Dirofilaria immitis, rarely affects humans and is usually asymptomatic, but may present as chest pain, cough, hemoptysis, wheezing, low-grade fever, and malaise. The dead and dying worms obstruct branches of the pulmonary artery, causing infarction and a granulomatous reaction. Coin lesions are apparent on radiography, raising concern of malignancy. Complete surgical excision is the treatment of choice and an anthelmintic can be administered if residual lesions are present or the patient is from an endemic area. We present two cases of pulmonary dirofilariasis presenting as coin lesions in the lung, which were clinically suggestive of malignancy.
