Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 7 de 7
Filtrar
Más filtros











Intervalo de año de publicación
7.
Anal Quant Cytol Histol ; 18(1): 9-18, 1996 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-8851103

RESUMEN

OBJECTIVE: To analyze cellular proliferating activity in breast cancer by means of a silver (Ag) method (AgNOR) that stains the nucleolar organizer regions (NORs), structures involved in protein transcription. STUDY DESIGN: We analyzed 126 invasive ductal carcinomas and we described: (1) staining modifications aimed at improving the silver method, (2) AgNOR quantitative variables obtained by image processing methods, and (3) the existing relationship between these AgNOR variables and other established breast prognostic factors, such as Scarf-Bloom-Richardson (SBR) grading, tumor size, axillary status, DNA index, and estrogen and progesterone receptors. RESULTS: All quantitative variables based on the AgNOR area showed statistically significant differences with reference to axillary status, tumor size and SBR grading. Cluster analysis based on these variables allowed us to detect two proliferation-level groups of breast carcinoma, one with a low and the other with a high proliferation level. Principal component analysis provided an AgNOR-independent component (first component) unrelated to other prognostic factors. CONCLUSION: Cellular proliferation assessed by AgNOR quantification provides information that may improve prognostic prediction in breast carcinoma.


Asunto(s)
Neoplasias de la Mama/patología , Carcinoma Ductal de Mama/patología , Región Organizadora del Nucléolo/patología , Neoplasias de la Mama/ultraestructura , Carcinoma Ductal de Mama/ultraestructura , División Celular , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador , Pronóstico , Plata , Coloración y Etiquetado/métodos
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA