Evaluation of perilipin 2 and melanocortin 5 receptor serum levels with sebogenesis in acne vulgaris patients.

INTRODUCTION: Acne vulgaris is a multifactorial disease. One of the main factors that plays a role in acne pathogenesis is an increase in sebum secretion. For sebum secretion, sebocyte differentiation followed by sebogenesis is essential. Sebocyte differentiation and proliferation, and sebum synthesis are controlled by complex pathways. Studies have shown that perilipin 2 and melanocortin 5 receptors play a role in sebogenesis. This study sought to determine whether levels of perilipin 2 and melanocortin 5 receptors have an impact on the development of acne vulgaris. METHODS: A total of 65 patients diagnosed with acne and 43 healthy control subjects were included in the study. Perilipin 2 and melanocortin 5 receptor levels were analyzed using the enzyme-linked immunosorbent assay (ELISA) technique. RESULTS: No significant differences were observed between the acne group and the control group in serum perilipin 2 (p = 0.594) and melanocortin 5 receptor (p = 0.213) levels. In the moderate acne group, perilipin 2 and melanocortin 5 receptor levels were significantly higher than in the mild acne group (p = 0.0014, p = 0.003). The levels in the severe acne group were not higher compared to the moderate and mild acne groups. CONCLUSION: This study failed to detect any association between acne pathogenesis and perilipin 2 and melanocortin 5 receptor serum levels. However, these proteins may have an influence on acne severity.

Staphylococcus aureus is the most common bacterial agent of the skin flora of patients with seborrheic dermatitis.

BACKGROUND: Seborrheic dermatitis is an inflammatory skin disease that affects 1-3% of the general population. The Malassezia species has been implicated as the main causative agent; however, the bacterial flora of the skin may also play role in the etiopathogenesis. Therefore, we investigated the most common bacterial agent of the skin flora of patients with seborrheic dermatitis. MATERIALS AND METHODS: Fifty-one patients with seborrheic dermatitis and 50 healthy individuals are included in this study. Sterile cotton swabs were rubbed on the scalp of the participants for bacterial culture. Colonial morphology was identified with gram stain and catalase test. RESULTS: Staphylococcus aureus was isolated from 25 (49%) patients with seborrheic dermatitis and 10 (20%) healthy individuals within the control group. Coagulase-negative staphylococci were isolated from 24 (47.1%) patients with seborrheic dermatitis and 17 (34%) healthy individuals within the control group. Diphtheroids were present in 2 (3.9%) patients and 1 (2%) subject within the control group. Gram-negative bacilli were present only in 1 (2%) patient. Hemolytic streptococci and bacilli were identified in 1 (2%) subject from each group. Colonization of coagulase-negative staphylococci, diphtheroids, gram-negative bacilli, hemolytic streptococci, and bacillus did not differ between patients and healthy controls. However, S. aureus colonization was significantly more common in patients with seborrheic dermatitis than in healthy controls. CONCLUSION: Within this study we revealed that S. aureus colonization was significantly higher among the patients. Therefore, we propose that, in addition to the Malassezia species, S. aureus may play a role in the etiopathogenesis of seborrheic dermatitis.

Inflamed bilateral linear atrophoderma of Moulin in an adult woman: a case report.

Linear atrophoderma of Moulin (LAM) is a rare dermatosis characterized by a hyperpigmented atrophoderma that follows Blaschko's lines, with onset usually occurring during childhood and adolescence. LAM is an etiologically unknown form of dermal atrophy. It is generally characterized by oval or round atrophic, nonsclerotic, hyperpigmented patches following Blaschko's lines. These patches are usually located on the trunk and the upper and lower extremities. This case study discusses a patient that had the nonclassical form of LAM with the initial lesions presenting as papules.

25-hydroxyvitamin D status in patients with alopecia areata.

INTRODUCTION: Alopecia areata (AA) is a T cell-mediated autoimmune disease that causes inflammation around anagen-phase hair follicles. Insufficient levels of vitamin D have been implicated in a variety of autoimmune diseases. AIM: To investigate the status of serum 25-hydroxyvitamin D (25(OH)D) in patients with AA, serum 25(OH)D concentrations were compared between AA patients and healthy controls and thus determine if a possible association exists between serum 25(OH)D levels and AA. MATERIAL AND METHODS: The study comprising 41 patients diagnosed with AA and 32 healthy controls was conducted between October 2010 and March 2011. The serum vitamin D levels of the study group were determined by high performance liquid chromatography. Serum levels of calcium, phosphorus, alkaline phosphatase, and parathyroid hormone were also evaluated. RESULTS: The study was based on 41 patients aged between 20 and 50 (mean: 32.8 ±7.5). The control group included 32 healthy persons aged between 20 and 51 (mean: 32.7 ±7.5). Serum 25(OH)D levels in patients with AA ranged from 5.0 to 38.6 ng/ml with a mean of 8.1 ng/ml. Serum 25(OH)D levels in healthy controls ranged from 3.6 to 38.5 ng/ml with a mean of 9.8 ng/ml. There was no statistically significant difference in the serum vitamin D level between AA patients and healthy controls (p > 0.05). CONCLUSIONS: Deficient serum 25(OH)D levels are present in patients with AA. However, considering the high prevalence of vitamin D deficiency in Turkey, no difference was noted between AA patients and controls.

A rare clinical manifestation of spinulate demodicosis.

Demodicosis is a chronic skin disease caused by Demodex mites such as Demodex folliculorum and Demodex brevis. Demodex mites live in pilosebaceous units and they are regarded as a part of the normal skin flora. Nevertheless, it has been suggested that the presence of five or more mites per cm² by the standardized skin surface biopsy technique could be considered as pathogenic.

Simple, easy, and still effective treatment option in severe rhinophyma: shave and paste.

A 74-year-old man suffering from severe rhinophyma with breathing difficulty and depression seeking for help presented to our clinic. The cauliflower-like mass was full thickness excised and a full thickness skin graft from right inguinal region was applied. An exceptionally treatment and satisfactory cosmetic result was obtained in single stage.

[Newborn with genital interlabial mass with spontaneous resolution: case report]. / Recién nacida con tumoración genital interlabial de resolución espontánea. Caso clínico.

Interlabial masses of newborns are rare issues that fall into the interest of pediatricians, pediatric surgeons, urologists, dermatologists and gynecologists. The most common are the hymenal cysts and paraurethral gland cysts. Several interlabial masses, including those of embryological origin, ectopic tissue, prolapse, urological anomaly, or neoplasia, can superficially resemble simple cysts. These include prolapsed urethra, prolapsed ectopic ureterocele, prolapsed vagina or uterus, Gartner's duct cyst, hydrometrocolpos associated with an imperforate hymen and botryoid rhabomyosarcoma. The differential diagnosis is important both for treatment approach and for follow up. We present a 3- day- old baby girl patient diagnosed with hymenal cyst.

Recién nacida con tumoración genital interlabial de resolución espontánea: Caso clínico / Newborn with genital interlabial mass with spontaneous resolution: Case report

Las tumoraciones interlabiales en las recién nacidas son temas infrecuentes, de interés para pediatras, cirujanos, urólogos, dermatólogos y ginecólogos infantiles. Los quistes interlabiales neonatales más frecuentes son los quistes himeneales y los quistes glandulares parauretrales. Varias tumoraciones interlabiales, incluyendo las de origen embrionario, tejido ectópico, prolapso, anomalías urinarias o neoplasias, pueden aparentar ser simples quistes. Entre estos están el prolapso de uretra, vagina o útero, el ureterocele ectópico, el quiste del conducto de Gartner, el hidrometrocolpos asociado a himen imperforado y el rabdomiosarcoma botroide. El diagnóstico diferencial es importante tanto para el enfoque terapéutico como por el seguimiento. Se presenta el caso de una niña de 3 días de edad con diagnóstico de quiste himeneal y sus posibles diagnósticos diferenciales.

Interlabial masses of newborns are rare issues that fall into the interest of pediatricians, pediatric surgeons, urologists, dermatologists and gynecologists. The most common are the hymenal cysts and paraurethral gland cysts. Several interlabial masses, including those of embryological origin, ectopic tissue, prolapse, urological anomaly, or neoplasia, can superficially resemble simple cysts. These include prolapsed urethra, prolapsed ectopic ureterocele, prolapsed vagina or uterus, Gartner's duct cyst, hydrometrocolpos associated with an imperforate hymen and botryoid rhabomyosarcoma. The differential diagnosis is important both for treatment approach and for follow up. We present a 3- day- old baby girl patient diagnosed with hymenal cyst.

Recién nacida con tumoración genital interlabial de resolución espontánea: Caso clínico / Newborn with genital interlabial mass with spontaneous resolution: Case report

Las tumoraciones interlabiales en las recién nacidas son temas infrecuentes, de interés para pediatras, cirujanos, urólogos, dermatólogos y ginecólogos infantiles. Los quistes interlabiales neonatales más frecuentes son los quistes himeneales y los quistes glandulares parauretrales. Varias tumoraciones interlabiales, incluyendo las de origen embrionario, tejido ectópico, prolapso, anomalías urinarias o neoplasias, pueden aparentar ser simples quistes. Entre estos están el prolapso de uretra, vagina o útero, el ureterocele ectópico, el quiste del conducto de Gartner, el hidrometrocolpos asociado a himen imperforado y el rabdomiosarcoma botroide. El diagnóstico diferencial es importante tanto para el enfoque terapéutico como por el seguimiento. Se presenta el caso de una niña de 3 días de edad con diagnóstico de quiste himeneal y sus posibles diagnósticos diferenciales.(AU)

Interlabial masses of newborns are rare issues that fall into the interest of pediatricians, pediatric surgeons, urologists, dermatologists and gynecologists. The most common are the hymenal cysts and paraurethral gland cysts. Several interlabial masses, including those of embryological origin, ectopic tissue, prolapse, urological anomaly, or neoplasia, can superficially resemble simple cysts. These include prolapsed urethra, prolapsed ectopic ureterocele, prolapsed vagina or uterus, Gartners duct cyst, hydrometrocolpos associated with an imperforate hymen and botryoid rhabomyosarcoma. The differential diagnosis is important both for treatment approach and for follow up. We present a 3- day- old baby girl patient diagnosed with hymenal cyst.(AU)

Recién nacida con tumoración genital interlabial de resolución espontánea. Caso clínico. / [Newborn with genital interlabial mass with spontaneous resolution: case report].

Interlabial masses of newborns are rare issues that fall into the interest of pediatricians, pediatric surgeons, urologists, dermatologists and gynecologists. The most common are the hymenal cysts and paraurethral gland cysts. Several interlabial masses, including those of embryological origin, ectopic tissue, prolapse, urological anomaly, or neoplasia, can superficially resemble simple cysts. These include prolapsed urethra, prolapsed ectopic ureterocele, prolapsed vagina or uterus, Gartners duct cyst, hydrometrocolpos associated with an imperforate hymen and botryoid rhabomyosarcoma. The differential diagnosis is important both for treatment approach and for follow up. We present a 3- day- old baby girl patient diagnosed with hymenal cyst.