Implementing QSPR modeling via multiple linear regression analysis to operations research: a study toward nanotubes.

Chemical graph theory significantly predicts multifarious physio-chemical properties of complex and multidimensional compounds when investigated through topological descriptors and QSPR modeling. The targeted compounds are widely studied nanotubes attaining exquisite nanostructures due to their distinguishable properties attaining numeric values. The studied nanotubes are carbon, naphthalene, boron nitride, V-phenylene, and titania nanotubes. In this research work, these nanotubes are characterized through their significance level by implementing highly applicable MCDM techniques. TOPSIS, COPRAS, and VIKOR are used to perform a comparative analysis between them through each optimal ranking. The criteria originated from multiple linear regression modeling established between degree-based topological descriptors and the physio-chemical properties of each nanotube.

Effect of medicinal plants, Heavy metals and antibiotics against pathogenic bacteria isolated from raw, Boiled and pasteurized milk.

Present study has been undertaken to isolate and identify the bacterial flora in raw, boiled and pasteurized milk. Agar disc diffusion method was used to determine their sensitivity using medicinal plants, antibiotics and heavy metals. Methylene blue reduction test was used to test the quality of milk samples. Total 10 pathogenic strains were isolated, five strains were isolated from raw milk, three from boiled milk and 2 two from pasteurized milk. To determine optimum conditions for growth, these pathogenic microorganisms were incubated at various temperatures and pH. Gram's staining and biochemical tests revealed that these pathogenic bacteria include Lactobacillus sp., E. coli, Salmonella sp., Pseudomonas sp., Streptococcus sp. and Staphylococcus. Ribotyping revealed S2 as Pseudomonas fluorescens, S5 as Lactococcus lactis and S9 as Lactobacillus acidophilus. Prevalence of pathogenic organisms provided the evidence that contamination of milk arises during milking, transportation and storage of milk. Raw milk is more contaminated than other two types of milk because it contains highest percentage of pathogenic organisms and pasteurized milk was found to be of best quality among three types. So it is recommended to drink milk after proper boiling or pasteurization. Proper pasteurization and hygienic packing of milk is essential to minimize contamination in milk which can save human beings from many milk borne diseases. Our study suggests that antimicrobial use in animal husbandry should be minimized to reduce the hazard of antibiotic resistance. Plant extracts are better alternative against pathogenic bacteria in milk.