Asunto(s)
Anticuerpos Monoclonales Humanizados/uso terapéutico , Carcinoma Basocelular/tratamiento farmacológico , Neoplasias del Oído/tratamiento farmacológico , Inhibidores de Puntos de Control Inmunológico/uso terapéutico , Neoplasias Cutáneas/tratamiento farmacológico , Anciano , Carcinoma Basocelular/patología , Pabellón Auricular/patología , Neoplasias del Oído/patología , Humanos , Masculino , Piel/patología , Neoplasias Cutáneas/patologíaRESUMEN
The scrotum is a rare site for metastases and represents less than 1% of the body's total surface area. Clinically, metastatic deposits in the scrotum can present in a variety of ways. They may appear as solitary cutaneous nodules, papules, plaques, or generalized induration or edema. Indeed, scrotum metastasis may be mistaken for other skin lesions since several dermatologic conditions can present with inflammation or dermatitis of the scrotum. Properly diagnosing cutaneous metastasis requires histopathological examination since the clinical appearances are, as described, highly variable and non-specific. We present a 63-year-old man with painless nodules on the scrotal skin. Excisional biopsy of the nodules revealed a metastasis from rectal squamous cell carcinoma. The incidence of this kind of tumors is estimated around 0.1-0.25â¯per 1000â¯colorectal neoplasms.
Asunto(s)
Carcinoma de Células Escamosas/secundario , Neoplasias de los Genitales Masculinos/secundario , Neoplasias del Recto/patología , Escroto/patología , Neoplasias Cutáneas/secundario , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Cutaneous leiomyosarcoma is a rare malignant mesenchymal tumor of smooth muscle origin of unknown etiology. Leiomyosarcomas located on the skin include superficial leiomyosarcomas and metastatic leiomyosarcomas. Superficial leiomyosarcomas represent 7-10% of all cases of leiomyosarcoma and are subdivided into cutaneous and subcutaneous lesions based on skin location. We report a case of an 81-year-old woman who presented a slow growing tender single nodule on the left thigh and describe its clinical and dermoscopic features.
Asunto(s)
Leiomiosarcoma/diagnóstico , Leiomiosarcoma/cirugía , Neoplasias Cutáneas/diagnóstico , Anciano de 80 o más Años , Biopsia , Femenino , Humanos , Inmunohistoquímica , Fenotipo , Piel/patología , Neoplasias Cutáneas/cirugía , Resultado del TratamientoRESUMEN
BACKGROUND: Recent studies have shown an increasing incidence of cutaneous adnexal carcinomas (CACs). OBJECTIVES: The aim of our study was to evaluate incidence and survival for cases of CACs and investigate their association with other skin neoplasms. METHODS: We conducted a population-based study. Data on incident cases of CACs were obtained from the Tuscany Cancer Registry between 1985 and 2010. In order to determine whether the occurrence of squamous cell carcinoma (SCC) among patients with CAC is higher or lower than expected in the general population, the standardized incidence ratio (SIR) was calculated. RESULTS: A total of 242 patients with CAC were observed; the age-standardized incidence rate was 3·8 cases per million person-years. From 1997 to 2010 crude incidence rates increased by 159%. Age-specific incidence was higher in men over 80 years old than in women of the same age and younger individuals. Carcinomas of sweat gland origin prevailed; the most common histotype was porocarcinoma and the most frequently affected site was the head/neck. Overall, 88% of CACs were diagnosed at a localized stage. The 5-year overall survival and disease-specific survival rates were 59% [95% confidence interval (CI) 53-65] and 94% (95% CI 91-98), respectively. In the observation cohort, the number of SCCs was significantly higher than expected as the SIR was calculated to be 33·7 (P < 0·001). CONCLUSIONS: Increasing incidence warrants awareness and early diagnosis of CACs. Increased SCC incidence among patients with these tumours highlights the relevance of careful skin examination and follow-up.
Asunto(s)
Carcinoma de Apéndice Cutáneo/epidemiología , Carcinoma de Células Escamosas/epidemiología , Costo de Enfermedad , Neoplasias Cutáneas/epidemiología , Adulto , Distribución por Edad , Factores de Edad , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Incidencia , Italia/epidemiología , Masculino , Persona de Mediana Edad , Sistema de Registros/estadística & datos numéricos , Factores de Riesgo , Distribución por Sexo , Factores Sexuales , Tasa de SupervivenciaRESUMEN
The malignant melanoma is a neoplasm associated with a wide variety of cutaneous paraneoplastic syndromes, as dermatomyositis, systemic sclerosis, paraneoplastic pemphigus. We describe a case of four multiple trichilemmal cystis arising on frontal region in the same patient with brain metastasis and unknown primary melanoma and discuss their relationship.
Asunto(s)
Melanoma/patología , Enfermedades de la Piel/patología , Neoplasias Cutáneas/patología , Piel/patología , Neoplasias Encefálicas/complicaciones , Neoplasias Encefálicas/secundario , Humanos , Masculino , Melanoma/complicaciones , Persona de Mediana Edad , Síndromes Paraneoplásicos/complicaciones , Síndromes Paraneoplásicos/patología , Enfermedades de la Piel/complicaciones , Neoplasias Cutáneas/complicacionesAsunto(s)
Glucocorticoides/administración & dosificación , Penfigoide Ampolloso/diagnóstico , Enfermedades Cutáneas Vesiculoampollosas/diagnóstico , Diagnóstico Diferencial , Femenino , Estudios de Seguimiento , Dermatosis del Pie/diagnóstico , Dermatosis del Pie/tratamiento farmacológico , Dermatosis del Pie/patología , Dermatosis de la Mano/diagnóstico , Dermatosis de la Mano/tratamiento farmacológico , Dermatosis de la Mano/patología , Humanos , Persona de Mediana Edad , Penfigoide Ampolloso/tratamiento farmacológico , Penfigoide Ampolloso/patología , Enfermedades Cutáneas Vesiculoampollosas/tratamiento farmacológico , Enfermedades Cutáneas Vesiculoampollosas/patología , Resultado del TratamientoAsunto(s)
Vasculitis Leucocitoclástica Cutánea/diagnóstico , Administración Oral , Dapsona/administración & dosificación , Fármacos Dermatológicos/administración & dosificación , Diagnóstico Diferencial , Humanos , Masculino , Persona de Mediana Edad , Vasculitis Leucocitoclástica Cutánea/tratamiento farmacológicoAsunto(s)
Insecticidas , Permetrina , Escabiosis/tratamiento farmacológico , Anciano de 80 o más Años , Femenino , HumanosRESUMEN
Although Malassezia yeasts are a part of the normal microflora, under certain conditions they can cause superficial skin infection, such as pityriasis versicolor (PV) and Malassezia folliculitis. Moreover the yeasts of the genus Malassezia have been associated with seborrheic dermatitis and dandruff, atopic dermatitis, psoriasis, and, less commonly, with confluent and reticulated papillomatosis, onychomycosis, and transient acantholytic dermatosis. The study of the clinical role of Malassezia species has been surrounded by controversy due to the relative difficulty in isolation, cultivation, and identification. This review focuses on the clinical, mycologic, and immunologic aspects of the various skin diseases associated with Malassezia. Moreover, since there exists little information about the epidemiology and ecology of Malassezia species in the Italian population and the clinical significance of these species is not fully distinguished, we will report data about a study we carried out. The aim of our study was the isolation and the identification of Malassezia species in PV-affected skin and non-affected skin in patients with PV and in clinically healthy individuals without any Malassezia associated skin disease.