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1.
Orthop J Sports Med ; 9(3): 2325967121994849, 2021 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-33855097

RESUMEN

BACKGROUND: The operative therapy of patellofemoral arthritis requires an individual approach depending on the underlying injury. However, the literature lacks recommendations for its course of action. PURPOSE: To generate an expert recommendation of therapy for different patellofemoral abnormalities in patients suffering from isolated patellofemoral arthritis. STUDY DESIGN: Consensus statement. METHODS: To generate recommendations, the AGA Patellofemoral Committee performed a consensus process using the Delphi method based on the available literature on isolated patellofemoral arthritis. RESULTS: In most statements and recommendations, a high percentage of consensus could be found. However, also in the expert group of the AGA Patellofemoral Committee, some controversies on the treatment of patellofemoral arthritis exist. CONCLUSION: The operative therapy of isolated patellofemoral arthritis is a challenging topic that leads to controversial discussions, even in an expert group. With this consensus statement of the AGA Patellofemoral Committee, recommendations on different operative treatment options were able to be generated, which should be considered in clinical practice.

2.
Arch Orthop Trauma Surg ; 140(2): 155-160, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-31267144

RESUMEN

PURPOSE: Trochlear dysplasia is one of the most important pathomorphologies predisposing to patellofemoral instability. The development of the trochlea groove is not well understood so far. We hypothesized that the underlying pathology of trochlear dysplasia is a medial hypoplasia. METHODS: 110 magnetic resonance imaging (MRI) scans from adult knees, 55 with and 55 without trochlear dysplasia were analyzed. On the axial and sagittal T2 MRI sequences, the height (h), width (w) and depth (d) of the medial (MC) and lateral femoral condyle (LC) as well as the depth of the trochlea groove (dTG) were measured using a three-dimensional measuring algorithm. RESULTS: For all calculated values of the lateral femoral condyle, the comparison of both groups showed no significant difference (p = 0.95, p = 0.11, p = 0.07). The depth of the trochlear groove (dTG) showed significant lower values in the study group (p < 0.05). In the study group, all measurements of the medial femoral condyle were statistically significantly smaller compared to the control group (p < 0.05). CONCLUSIONS: We found that the height, the width and the depth of the medial condyle is significant smaller in patients with trochlea dysplasia than in healthy controls. The measurements of the lateral femoral condyle showed no significant difference. Patients with a dysplastic trochlea have a hypoplastic medial femoral condyle and a more medially placed trochlea groove compared to controls.


Asunto(s)
Enfermedades Óseas , Fémur , Inestabilidad de la Articulación , Imagen por Resonancia Magnética , Enfermedades Óseas/diagnóstico por imagen , Enfermedades Óseas/patología , Fémur/diagnóstico por imagen , Fémur/patología , Humanos , Inestabilidad de la Articulación/diagnóstico por imagen , Inestabilidad de la Articulación/patología
3.
Int J Mol Sci ; 20(7)2019 Mar 27.
Artículo en Inglés | MEDLINE | ID: mdl-30934789

RESUMEN

Cartilage defects represent an increasing pathology among active individuals that affects the ability to contribute to sports and daily life. Cell therapy, such as autologous chondrocyte implantation (ACI), is a widespread option to treat larger cartilage defects still lacking standardization of in vitro cell culture parameters. We hypothesize that mRNA expression of cytokines and proteases before and after ACI is influenced by in vitro parameters: cell-passage, cell-density and membrane-holding time. Knee joint articular chondrocytes, harvested from rabbits (n = 60), were cultured/processed under varying conditions: after three different cell-passages (P1, P3, and P5), cells were seeded on 3D collagen matrices (approximately 25 mm³) at three different densities (2 × 105/matrix, 1 × 106/matrix, and 3 × 106/matrix) combined with two different membrane-holding times (5 h and two weeks) prior autologous transplantation. Those combinations resulted in 18 different in vivo experimental groups. Two defects/knee/animal were created in the trochlear groove (defect dimension: ∅ 4 mm × 2 mm). Four identical cell-seeded matrices (CSM) were assembled and grouped in two pairs: One pair giving pre-operative in vitro data (CSM-i), the other pair was implanted in vivo and harvested 12 weeks post-implantation (CSM-e). CSMs were analyzed for TNF-α, IL-1ß, MMP-1, and MMP-3 via qPCR. CSM-i showed higher expression of IL-1ß, MMP-1, and MMP-3 compared to CSM-e. TNF-α expression was higher in CSM-e. Linearity between CSM-i and CSM-e values was found, except for TNF-α. IL-1ß expression was higher in CSM-i at higher passage and longer membrane-holding time. IL-1ß expression decreased with prolonged membrane-holding time in CSM-e. For TNF-α, the reverse was true. Lower cell-passages and lower membrane-holding time resulted in stronger TNF-α expression. Prolonged membrane-holding time resulted in increased MMP levels among CSM-i and CSM-e. Cellular density was of no significant effect. We demonstrated cytokine and MMP expression levels to be directly influenced by in vitro culture settings in ACI. Linearity of expression-patterns between CSM-i and CSM-e may predict ACI regeneration outcome in vivo. Cytokine/protease interaction within the regenerate tissue could be guided via adjusting in vitro culture parameters, of which membrane-holding time resulted the most relevant one.


Asunto(s)
Condrocitos/citología , Condrocitos/trasplante , Matriz Extracelular/metabolismo , Inflamación/metabolismo , Inflamación/patología , Animales , Células Cultivadas , Condrocitos/metabolismo , Citocinas/metabolismo , Modelos Animales de Enfermedad , Mediadores de Inflamación/metabolismo , Metaloproteinasas de la Matriz/metabolismo , ARN Mensajero/genética , ARN Mensajero/metabolismo , Conejos , Trasplante Autólogo
4.
Knee Surg Sports Traumatol Arthrosc ; 26(9): 2679-2684, 2018 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-28785790

RESUMEN

PURPOSE: The aim of this study was to adapt, translate, and validate the Banff Patella Instability Instrument (BPII) 2.0 into German, enabling its use by German-speaking professionals for the evaluation of patients who present with patellofemoral instability. METHODS: Forward and backward translation was performed according to international recommendations. The final German version of the BPII 2.0 was investigated in patients with confirmed diagnoses of recurrent patellofemoral instability in Germany, Austria, and Switzerland. All patients received two packages of questionnaires, each containing the BPII 2.0, Kujala scoring questionnaire, Norwich Patella Instability scoring questionnaire, Short Form-36 (SF-36), and a visual analogue scale (VAS)-scale for pain and disability. The first and second packages of questionnaires were to be completed 7 days apart. The following parameters were assessed: internal consistency, test-retest reliability, floor and ceiling effects, and construct validity. RESULTS: The study population consisted of 64 patients (24 males and 40 females). The average age of the patients was 22 ± 6 years. The internal consistency (Cronbach's alpha) was excellent at both time points (0.93 and 0.95), and the test-retest reliability (ICC) was good (0.89). There were no floor or ceiling effects. There were statistically significant correlations between the BPII 2.0 and all other outcome measures apart from SF-36 mental health. CONCLUSION: The BPII 2.0 was successfully adapted into German. It is a reliable and valid instrument for evaluation of German-speaking patients who present with patellofemoral instability. LEVEL OF EVIDENCE: III.


Asunto(s)
Indicadores de Salud , Inestabilidad de la Articulación/diagnóstico , Luxación de la Rótula/diagnóstico , Articulación Patelofemoral , Adulto , Austria , Femenino , Humanos , Masculino , Dolor , Dimensión del Dolor , Evaluación del Resultado de la Atención al Paciente , Calidad de Vida , Recurrencia , Reproducibilidad de los Resultados , Encuestas y Cuestionarios , Traducción , Traducciones
5.
Knee Surg Sports Traumatol Arthrosc ; 25(9): 2784-2791, 2017 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-26231153

RESUMEN

PURPOSE: To compare clinical and radiographic results after isolated patellofemoral arthroplasty (PFA) using either a second-generation inlay or onlay trochlear design. The hypothesis was that an inlay design will produce better clinical results and less progression of tibiofemoral osteoarthritis (OA) compared to an onlay design. METHODS: Fifteen consecutive patients undergoing isolated PFA with an onlay design trochlear component (Journey™ PFJ, Smith & Nephew) were matched with 15 patients after isolated PFA with an inlay design trochlear component (HemiCAP® Wave, Arthrosurface). Matching criteria were age, gender, body mass index, and follow-up period. An independent observer evaluated patients prospectively, whereas data were compared retrospectively. Clinical outcome was assessed using WOMAC, Lysholm score, and pain VAS. Kellgren-Lawrence grading was used to assess progression of tibiofemoral OA. RESULTS: Conversion to total knee arthroplasty was necessary in one patient within each group, leaving 14 patients per group for final evaluation. The mean follow-up was 26 months in the inlay group and 25 months in the onlay group (n.s.). Both groups displayed significant improvements of all clinical scores (p < 0.05). No significant differences were found between the two groups with regard to the clinical outcome and reoperation rate. No significant progression of tibiofemoral OA was observed in the inlay group, whereas 53 % of the onlay group showed progression of medial and/or lateral tibiofemoral OA (p = 0.009). CONCLUSION: Isolated PFA using either a second-generation inlay or onlay trochlear component significantly improves functional outcome scores and pain. The theoretical advantages of an inlay design did not result in better clinical outcome scores; however, progression of tibiofemoral OA was significantly less common in patients with an inlay trochlear component. This implant design may therefore improve long-term results and survival rates after isolated PFA. LEVEL OF EVIDENCE: III.


Asunto(s)
Artroplastia/instrumentación , Prótesis de la Rodilla , Osteoartritis de la Rodilla/cirugía , Articulación Patelofemoral/cirugía , Adulto , Anciano , Artroplastia/métodos , Progresión de la Enfermedad , Femenino , Estudios de Seguimiento , Humanos , Masculino , Análisis por Apareamiento , Persona de Mediana Edad , Osteoartritis de la Rodilla/diagnóstico por imagen , Articulación Patelofemoral/diagnóstico por imagen , Radiografía , Reoperación , Estudios Retrospectivos , Resultado del Tratamiento
6.
Clin Biomech (Bristol, Avon) ; 33: 20-25, 2016 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-26896691

RESUMEN

BACKGROUND: Use of a rigid brace or cast immobilization is recommended in conservative treatment or postoperative rehabilitation after a posterior cruciate ligament injury. To prevent the loss of knee joint function and muscle activity often associated with this, a flexible knee brace has been developed that allows an adjustable anteriorly directed force to be applied to the calf in order to prevent posterior tibial translation. The purpose of this biomechanical study was to evaluate the impact of this novel dynamic brace on posterior tibial translation after posterior cruciate ligament injury and reconstruction. METHODS: A Telos stress device was used to provoke posterior tibial translation in seven human lower limb specimens, and stress radiographs were taken at 90° of knee flexion. Posterior tibial translation was measured in the native knees with an intact posterior cruciate ligament; after arthroscopic posterior cruciate ligament dissection with and without a brace; and after posterior cruciate ligament reconstruction with and without a brace. The force applied with the brace was measured using a pressure sensor. FINDINGS: Posterior tibial translation was significantly reduced (P=0.032) after application of the brace with an anteriorly directed force of 50N to the knees with the dissected posterior cruciate ligament. The brace also significantly reduced posterior tibial translation after posterior cruciate ligament reconstruction in comparison with reconstructed knees without a brace (P=0.005). INTERPRETATION: Posterior tibial translation was reduced to physiological values using this dynamic brace system that allows an anteriorly directed force to be applied to the calf.


Asunto(s)
Reconstrucción del Ligamento Cruzado Anterior/rehabilitación , Tirantes , Rodilla/fisiopatología , Ligamento Cruzado Posterior/lesiones , Ligamento Cruzado Posterior/cirugía , Anciano , Anciano de 80 o más Años , Fenómenos Biomecánicos , Femenino , Humanos , Rodilla/diagnóstico por imagen , Pierna/fisiopatología , Persona de Mediana Edad , Ligamento Cruzado Posterior/fisiopatología , Tibia/fisiopatología
7.
J Orthop Sci ; 20(5): 830-6, 2015 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-26063596

RESUMEN

BACKGROUND: This study evaluated the outcome of a third generation modular non-cemented reverse total shoulder arthroplasty (RTSA) in incongruent glenohumeral degeneration with severe rotator cuff deficiency. MATERIALS AND METHODS: Thirty-eight consecutive RTSA with a mean age of 72 years (range 58-89 years) were prospectively enrolled. Mean follow-up was 24 months (range 21-29 months). Pain and standardized clinical functional scores were monitored. Radiographic and MRI findings have been scored and correlated to clinical outcome and complication rate. RESULTS: Preoperative pain decreased significantly from VAS 8 to 2 at 24 months postop., as ROM improved significantly, by at least doubling preoperative values of elevation, abduction, and external rotation. Nevertheless, internal rotation languished. The preoperative median constant was 18 points and 70 points 24 months postop. (p < 0.001). Initial median DASH was 95 vs. 50 2 years after surgery (p < 0.001). Median prospective ASES was 23 (IQR 8-33) vs. 70 points (p < 0.001) at final follow-up. Each outcome measurement improved significantly at 6, 12, and 24 months follow-up. There was no significant correlation between pre-operative radiographic findings of osseous and/or soft-tissue degeneration and short-term clinical outcome and/or complication rate (13 %). At final follow-up, 54 % showed radiographic signs of inferior scapular notching. There was no revision and/or loosening observed. CONCLUSION: RSTA with this modular system results in significant pain relief and improvement of functional clinical outcomes. However, longevity of the device is currently unknown.


Asunto(s)
Actividades Cotidianas , Artroplastia de Reemplazo/métodos , Osteoartritis/cirugía , Rango del Movimiento Articular , Articulación del Hombro/cirugía , Anciano , Anciano de 80 o más Años , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Reoperación , Manguito de los Rotadores/cirugía , Articulación del Hombro/fisiopatología , Resultado del Tratamiento
8.
J Knee Surg ; 28(4): 297-302, 2015 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-25581230

RESUMEN

Patellofemoral instability (PFI) is a pathological knee syndrome that frequently affects young patients. The patellofemoral joint's structural morphology is the determining factor in the extent of PFI. Structural factors that play leading roles in patellofemoral stability can be classified into static (bone morphology), passive (ligamentous), and active (muscular). The predominant static factor leading to patella dislocation and thus patellofemoral dysfunction is trochlear dysplasia, which we focus on in this review. After orienting clinical examinations, MRI can provide the best information about trochlear dysplasia. This includes trochlear shape, orientation, and tibial tuberosity to trochlear groove distance. In convex trochleas or trochlea dysplasia with PFI at flexion over 30 degrees, we recommend performing a deepening trochleoplasty to correct for static pathomorphology. In this review, we will focus on the pathology of trochlea dysplasia, its role in PFI, the correct indication for trochleoplasty as a primary intervention, and the role of a simultaneous medial patellofemoral ligament reconstruction.


Asunto(s)
Inestabilidad de la Articulación/cirugía , Articulación Patelofemoral/cirugía , Humanos , Inestabilidad de la Articulación/etiología , Articulación Patelofemoral/patología
9.
Knee Surg Sports Traumatol Arthrosc ; 23(5): 1299-307, 2015 May.
Artículo en Inglés | MEDLINE | ID: mdl-24310926

RESUMEN

PURPOSE: To prospectively evaluate the clinical, radiographic, and sports-related outcomes at 24 months after isolated and combined patellofemoral inlay resurfacing (PFIR). METHODS: Between 2009 and 2010, 29 consecutive patients with patellofemoral osteoarthritis (OA) were treated with the HemiCAP(®) Wave Patellofemoral Resurfacing System (Arthrosurface, Franklin, MA, USA). Based on preoperative findings, patients were divided into two groups: group I, isolated PFIR (n = 20); and group II, combined PFIR with concomitant procedures to address patellofemoral instability, patellofemoral malalignment, and tibiofemoral malalignment (n = 9). Patients were evaluated preoperatively and at 24 months postoperatively. Clinical outcomes included WOMAC, subjective IKDC, Pain VAS, Tegner activity score, and a self-designed sports questionnaire. Kellgren-Lawrence grading was used to assess progression of tibiofemoral OA. The Caton-Deschamps Index was used to assess differences in patellar height. RESULTS: Twenty-seven patients (93 %) were available for 24-month follow-up. Eighty-one per cent of the patients were either satisfied or very satisfied with the overall outcome. Significant improvements in the WOMAC, subjective IKDC, and Pain VAS were seen in the overall patient cohort and in both subgroups. The median Tegner score and sports frequency showed a significant increase in the overall patient cohort and in group II. The number of sports disciplines increased significantly in both subgroups. No significant progression of tibiofemoral OA or changes in patellar height were observed. CONCLUSION: Patellofemoral inlay resurfacing is an effective and safe procedure in patients with symptomatic patellofemoral OA. Significant improvements in functional scores and sports activity were found after both isolated and combined procedures. LEVEL OF EVIDENCE: Prospective case series, Level III.


Asunto(s)
Articulación de la Rodilla/cirugía , Osteoartritis de la Rodilla/cirugía , Rótula/cirugía , Articulación Patelofemoral/cirugía , Volver al Deporte/fisiología , Deportes , Adulto , Progresión de la Enfermedad , Femenino , Estudios de Seguimiento , Humanos , Articulación de la Rodilla/diagnóstico por imagen , Articulación de la Rodilla/fisiología , Masculino , Persona de Mediana Edad , Osteoartritis de la Rodilla/diagnóstico por imagen , Osteoartritis de la Rodilla/fisiopatología , Articulación Patelofemoral/diagnóstico por imagen , Articulación Patelofemoral/fisiopatología , Periodo Posoperatorio , Estudios Prospectivos , Radiografía , Factores de Tiempo
10.
Knee Surg Sports Traumatol Arthrosc ; 22(11): 2591-8, 2014 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-23851967

RESUMEN

PURPOSE: Excessive trochlear dysplasia may be responsible for recurrent patellofemoral instability (PFI) due to a missing bony guidance for the patella in early flexion. Thus, an isolated medial patellofemoral ligament reconstruction (MPFLR) can be insufficient, since it mainly addresses instability close to extension and additionally can increase patellofemoral pressure leading to pain in flat or convex trochlear dysplasia. Therefore, in combination with a trochleoplasty, an anatomical trochlear groove is created, resulting in patellofemoral stability also in flexion, while patellofemoral pressure is normalized. In this prospective study, we evaluated the outcome of open trochleoplasty in combination with MPFLR with a minimum follow-up of 2 years for treatment of excessive PFI. METHODS: In between 2007 and 2009, 18 knees of 17 consecutive patients (mean age of 22.2 ± 4.9 years) with trochlear dysplasia type B, C or D according to Dejour et al. and positive apprehension from 0 to 60° of flexion were included. Tegner, Kujala and IKDC scores, apprehension and pain, trochlear dysplasia, sulcus angle, tibial tuberosity trochlear groove, patellar tilt and shift, Caton-Deschamps index as well as patellofemoral arthrosis according to the classification of Iwano et al. were assessed pre- and postoperatively. RESULTS: At a mean of 30.5 ± 5.9 months, all but one patient were subjectively satisfied with the outcome of the procedure, all showing absence of positive apprehension or redislocation. Significant (p < 0.001) reduction in pain (5.6 to 2.5 ± 2.8 points, VAS) and increase in Tegner (2, range 0-4 points to 6, range 3-8 points), Kujala (51.1 to 87.9 ± 20.0 points) and IKDC (49.5 to 80.2 ± 21.0%) scores could be achieved. Radiologically significant (p < 0.02) improvement of patellofemoral positional parameters leading to more normal anatomy was recorded, while short-term arthrosis was absent. CONCLUSIONS: Combined treatment for trochleoplasty with MPFLR serves as a successful therapy for chronic PFI. This combinatory treatment concept is a reliable option not only as salvage therapy but also as primary procedure regarding treatment for excessive PFI. LEVEL OF EVIDENCE: Prospective case series, Level IV.


Asunto(s)
Fémur/cirugía , Inestabilidad de la Articulación/cirugía , Ligamentos Articulares/cirugía , Luxación de la Rótula/cirugía , Articulación Patelofemoral/cirugía , Adolescente , Enfermedad Crónica , Femenino , Fémur/anomalías , Estudios de Seguimiento , Humanos , Masculino , Osteotomía/métodos , Estudios Prospectivos , Rango del Movimiento Articular , Procedimientos de Cirugía Plástica , Tendones/trasplante , Adulto Joven
11.
Am J Sports Med ; 41(9): 2128-35, 2013 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-23925574

RESUMEN

BACKGROUND: Persistent pain and redislocations after surgical treatment of patellofemoral instability are described in up to 40% of patients. However, prospective outcome data about revision surgery are missing. PURPOSE: To evaluate the clinical outcome after revision medial patellofemoral ligament (MPFL) reconstruction using isolated and combined procedures, with a follow-up of 24 months. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Study participants were 42 patients (median age, 22 years; range, 13-46 years) who underwent revision surgery between January 2007 and December 2009 because of persistent patellofemoral instability after a mean of 1.8 previous failed surgical interventions (lateral release, medial imbrication/vastus medialis obliquus distalization, medialization of the tuberosity). An isolated MPFL reconstruction was performed in 15 cases, while a combination procedure was performed in 27 cases. The clinical results were evaluated preoperatively and 24 months postoperatively using the International Knee Documentation Committee (IKDC), Kujala, and Tegner scores as well as a subjective questionnaire. Patellar shift, tilt, and height, as well as level of degeneration, were defined preoperatively and at the latest follow-up on plain radiographs and magnetic resonance imaging. RESULTS: At 24-month follow-up, 87% of the patients were satisfied or very satisfied with the treatment. No apprehension or redislocation was reported at follow-up, and there was a significant decrease in pain during daily activities. There were significant improvements (P < .001) in IKDC (from 50 to 80), Kujala (from 51 to 85), and Tegner scores (from 2.4 to 4.9). Patellar shift, tilt, and height decreased significantly (P < .05) to anatomic values, and there was no aggravation to the level of pre-existing degeneration. No significant difference was noticed between the isolated and combined procedures. CONCLUSION: As patellofemoral instability is a multifactorial problem, revision surgery should be indicated only after a comprehensive examination. The results of this study show that MPFL reconstruction, alone or in combination, seems to be an effective treatment for recurrent patellar dislocations after a failed previous surgery, leading to significant increases in stability and functionality as well as a reduction in pain.


Asunto(s)
Inestabilidad de la Articulación/cirugía , Ligamentos Articulares/cirugía , Articulación Patelofemoral/cirugía , Adolescente , Adulto , Femenino , Humanos , Inestabilidad de la Articulación/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Articulación Patelofemoral/diagnóstico por imagen , Satisfacción del Paciente , Estudios Prospectivos , Radiografía , Reoperación , Resultado del Tratamiento , Adulto Joven
12.
Knee Surg Sports Traumatol Arthrosc ; 21(2): 332-9, 2013 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-22547249

RESUMEN

PURPOSE: The purpose was to prospectively evaluate the two-year results after implantation of the Journey PFJ(®) (Smith & Nephew, Andover, MA). The authors hypothesized that patellofemoral arthroplasty would result in improved outcomes after 24 months in patients treated with an isolated procedure as well as in patients demonstrating concomitant patellofemoral instability (PFI), which were treated with a combined surgical procedure. METHODS: Patients were included between 02/2006 and 08/2008. According to the history and clinical findings, patients were grouped into group I with no history or clinical signs of PFI, and patients with concomitant PFI were assorted to group II. Patients were then treated with an isolated (group I) or a combined (group II) surgical procedure to additionally treat the PFI. Visual analogue scale (VAS), Lysholm score and WOMAC score were recorded preoperatively, 6, 12 and 24 months postoperatively. Patellar height was evaluated according to the index of Caton-Deschamps (CDI), and osteoarthritic changes were evaluated according to Kellgren and Lawrence. RESULTS: A total of 25 patients were enrolled, of them three discontinued interventions and were excluded from final analysis. An isolated implantation of the Journey PFJ(®) was performed in 14 patients (group I) and a combined procedure in 8 (group II). Daily pain and clinical scores significantly improved at 6, 12 and 24 months compared to preoperative values (P < 0.05). Significant decrease (P = 0.02) of mean CDI could be noticed. Significant increase in tibiofemoral OA within the medial but not in the lateral tibiofemoral joint was assessed (P = 0.011; n.s.). CONCLUSIONS: Patellofemoral arthroplasty using the Journey(®) PFJ for treatment of significant patellofemoral OA demonstrated improved clinical scores at the 2-year follow-up in both groups. Comparing the primary OA (I) and OA + instability (II) groups, patients with patellofemoral OA treated with a combined procedure for concomitant stabilization of patellofemoral instability may benefit more from such a combined procedure, than patients treated with an isolated procedure for treatment of isolated patellofemoral OA. LEVEL OF EVIDENCE: Prospective case series, Level III.


Asunto(s)
Artroplastia de Reemplazo de Rodilla/instrumentación , Inestabilidad de la Articulación/cirugía , Prótesis de la Rodilla , Osteoartritis de la Rodilla/cirugía , Articulación Patelofemoral/cirugía , Adulto , Anciano , Artralgia/cirugía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Diseño de Prótesis
13.
Biomaterials ; 32(25): 5810-8, 2011 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-21592563

RESUMEN

Matrix-assisted chondrocyte transplantation (m-ACI) still lacks any standardization in its execution in terms of cell passage (P), cell yield (C) and in vitro membrane-holding time (T). It was the goal of this study to analyze the effect of shifting cell culture parameters (P, C, T) on the in vitro as well as in vivo effort of a regulated animal m-ACI. Autologous rabbit knee articular chondrocytes were seeded within bilayer collagen I/III 3-D matrices in variation of P, C and T. Each time, 2 PCT-identical by 2 PCT-identical cell-matrix-constructs (CMC)/animal were created. Simultaneously 2 (PCT-distinct) were re-implanted (CMC-e) autologous into artificial trochlear pristine chondral defects in vivo to remain for 12 weeks while the remaining 2 were harvested (CMC-i) for immediate in vitro analysis at the time of transplantation of their identical twins. mRNA of both, CMC-e regenerates and CMC-i membranes, was analyzed for Collagen-1,-2,-10, COMP, Aggrecan, Sox9 expression by use of a mixed linear model, multiple regression analysis. Generally, CMC-i values were higher than CMC-e values for differentiation targets; the opposite was true for dedifferentiation targets. Regarding individual gene expression, in vivo regenerate cell-matrix properties were significantly dependent on initial cell-matrix in vitro values as a sign of linearity. The parameter membrane-holding time (T) had strongest effects on the resulting mRNA expression with slightly less impact of the parameter passage (P), whereas cell yield (C) had clearly less effects. Noting differences between in vitro and in vivo data, in general, optimal expression patterns concerning chondrogenic differentiation were achieved by few passages, medium cellular yield, short membrane-holding time. Clinical m-ACI may benefit from optimal orchestration of the cell culture parameters passage, yield and time.


Asunto(s)
Condrocitos/trasplante , Animales , Secuencia de Bases , Cartilla de ADN , Proteínas/administración & dosificación , Proteínas/metabolismo , Conejos , Trasplante Autólogo , Resultado del Tratamiento
14.
Oper Orthop Traumatol ; 22(4): 387-401, 2010 Oct.
Artículo en Alemán | MEDLINE | ID: mdl-20931318

RESUMEN

OBJECTIVE: To improve the posterior translational stability of the knee joint by anatomic reconstruction of the posterior cruciate ligament in double-bundle technique. The functional bundles are reconstructed by native grafts from semitendinosus and gracilis muscles. The grafts are fixed with bioabsorbable screws in aperture technique. INDICATIONS: Symptomatic tears of the posterior cruciate ligament (classification by Harner) or chronic posterior or posterolateral instabilities; combined instabilities may need extended operative procedure. CONTRAINDICATIONS: Open growth plate. Fixed posterior drawer position. Nonjustifiable operative risks. Decline of the operation by the patient. Noncompliance. SURGICAL TECHNIQUE: Graft harvest of the semitendinosus and gracilis tendons via a 3-cm skin incision parallel to pes anserinus. Preparation, multilooping and arming of the tendons with sutures, arthroscopy, resection of the stump of the posterior cruciate ligament and clearing of its origin and insertion (using an additional posteromedial portal). Tunnel placement by means of aiming devices in the following order: femoral anterolateral, femoral posteromedial, and tibial (by accurate protection of the popliteal structures). Passing in the bundles, fixation in biomechanical functional positions in the following order: posteromedial bundle femoral (90° flexion), tibial (extension 0°), and anterolateral bundle femoral (90° flexion) with bioabsorbable interference screws. POSTOPERATIVE MANAGEMENT: 6 weeks PTS orthesis for 24 h/7 days with partial weight bearing (20 kg). Increased weight bearing from 7th postoperative week with PCL support orthesis during daytime and PTS orthesis during nighttime for further 6 weeks. Return to sports after 6 months at the earliest, no contact sports and competition for at least 9 months. RESULTS: First studies show positive results after reconstruction of the posterior cruciate ligament in double-bundle technique. A comparison with the single-bundle technique with a sufficient number of cases has not been published yet.


Asunto(s)
Tornillos Óseos , Inestabilidad de la Articulación/cirugía , Músculo Esquelético/trasplante , Procedimientos de Cirugía Plástica/métodos , Ligamento Cruzado Posterior/lesiones , Ligamento Cruzado Posterior/cirugía , Femenino , Humanos , Traumatismos de la Rodilla/cirugía , Masculino , Persona de Mediana Edad , Procedimientos de Cirugía Plástica/instrumentación , Resultado del Tratamiento
15.
J Biomech ; 43(16): 3237-9, 2010 Dec 01.
Artículo en Inglés | MEDLINE | ID: mdl-20708188

RESUMEN

Although the relationship between contact area and pressure under physiological loading has been described in the feline patellofemoral joint, this interaction has only been examined under simplified loading conditions and/or considerably lower forces than those occurring during demanding activities in humans. We hypothesized that patellofemoral contact area increases non-linearly under an increasing joint reaction force to regulate patellofemoral pressure. Eight human cadaveric knees were ramp loaded with muscle forces representative of the stance phase of stair climbing at 30° knee flexion. Continuous pressure data were acquired with a pressure sensitive film that was positioned within the patellofemoral joint. While pressure was linearly dependent upon the resulting joint reaction force, contact area asymptotically approached a maximum value and reached 95% of this maximum at patellofemoral forces of 349-723N (95% CI). Our findings indicate that the regulatory influence of increasing contact area to protect against high patellofemoral pressure is exhausted at relatively low loads.


Asunto(s)
Articulación Patelofemoral/fisiología , Animales , Fenómenos Biomecánicos , Gatos , Marcha/fisiología , Humanos , Técnicas In Vitro , Modelos Biológicos , Dinámicas no Lineales , Presión , Rango del Movimiento Articular/fisiología , Estrés Mecánico , Soporte de Peso/fisiología
16.
Knee Surg Sports Traumatol Arthrosc ; 18(4): 480-5, 2010 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-19826790

RESUMEN

Since a dysplastic trochlea has been identified as the main pathomorphology in recurrent patellofemoral instability, trochleoplasty became a surgical solution in some of these cases. However, in comparison to other surgical procedures stabilizing the patellofemoral joint, trochleoplasty is a major operation with an arthrotomy, and associated typical risks of open surgery such as arthrofibrosis. Therefore, we developed a technique to perform an arthroscopic deepening trochleoplasty via suprapatellar portals using shaver burrs. Comparable to the open procedure, a cartilage flake is released and a new bony trochlea is created according to the normal anatomy. Then, the cartilage flake is re-fixated using Vicryl tapes and anchors. This method seems to be an obvious advantage in patellofemoral surgery, since an arthrotomy can be avoided, and postoperative pain as well as soft tissue healing time can be reduced.


Asunto(s)
Artroplastia/métodos , Artroscopía/métodos , Inestabilidad de la Articulación/cirugía , Articulación Patelofemoral/cirugía , Adolescente , Adulto , Femenino , Humanos , Masculino , Adulto Joven
17.
Arch Orthop Trauma Surg ; 130(3): 335-40, 2010 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-19504114

RESUMEN

INTRODUCTION: A dysplastic trochlea. may be missed on conventional roentgenography due to superimposition effects of the distal femoral groove. METHODS: Measurements of (1) the sulcus angle, (2) the lateral trochlear slope angle and (3) the lateral to medial trochlear ratio were compared between plain axial radiographs and axial magnetic resonance images (MRI) in 24 patients suffering from clinical patellofemoral instability. Trochlear dysplasia was classified into type A through D on MR images. RESULTS: Measurements for (1) were significantly different among all dysplasia types. It was 135.6 degrees +/- 19.8 degrees on X-ray while it was above 180 degrees on MRI within dysplasia type D patients. Measurements for (2) were different among all dysplasia types, reaching statistical significance in type B dysplasia patients. Differences between radiographs and MRI for (3) were not significant, while only on MRI the ratio increased with increasing degree of dysplasia. CONCLUSION: The investigation illustrates that plain axial radiographs do not represent the natural bony trochlear morphology and may mislead further clinical management.


Asunto(s)
Inestabilidad de la Articulación/diagnóstico , Articulación de la Rodilla/anatomía & histología , Articulación de la Rodilla/diagnóstico por imagen , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Rótula/patología , Radiografía
18.
Knee Surg Sports Traumatol Arthrosc ; 18(2): 147-51, 2010 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-19593547

RESUMEN

Since biomechanical studies have shown that the medial patellofemoral ligament (MPFL) is the main restraint against lateral patella displacement, reconstruction of the MPFL has become an accepted method of restoring patellofemoral stability and numerous techniques were described. Due to biomechanical examinations and clinical results, an anatomical double-bundle reconstruction of the "sail-like" MPFL is a reasonable method for achieving stability during complete extension and lower flexion degree. This method also serves to avoid rotation of the patella, providing immediate stability throughout the normal range of motion. However, until today, an aperture fixation technique at the patellar insertion with two bundles has not been described previously. This technique can provide an immediate stability to allow an early rehabilitation with full range of motion.


Asunto(s)
Ligamentos Articulares/cirugía , Procedimientos Ortopédicos/métodos , Articulación Patelofemoral/cirugía , Tendones/trasplante , Artroscopía/métodos , Humanos , Inestabilidad de la Articulación/cirugía , Ligamentos Articulares/anatomía & histología , Luxación de la Rótula/cirugía , Anclas para Sutura , Trasplante Autólogo
19.
J Biomech ; 42(15): 2590-6, 2009 Nov 13.
Artículo en Inglés | MEDLINE | ID: mdl-19656517

RESUMEN

The mechanical environment during stair climbing has been associated with patellofemoral pain, but the contribution of loading to this condition is not clearly understood. It was hypothesized that the loading conditions during stair climbing induce higher patellofemoral pressures, a more lateral force distribution on the trochlea and a more lateral shift and tilt of the patella compared to walking at early knee flexion. Optical markers for kinematic measurements were attached to eight cadaveric knees, which were loaded with muscle forces at instances of walking and stair climbing cycles at 12 degrees and 30 degrees knee flexion. Contact mechanics were determined using a pressure sensitive film. At 12 degrees knee flexion, stair climbing loads resulted in higher peak pressure (p=0.012) than walking, more lateral force distribution (p=0.012) and more lateral tilt (p=0.012), whilst mean pressure (p=0.069) and contact area (p=0.123) were not significantly different. At 30 degrees knee flexion, although stair climbing compared to walking loads resulted in significantly higher patellofemoral mean (p=0.012) and peak pressures (p=0.012), contact area (p=0.025), as well as tilt (p=0.017), the medial-lateral force distribution (p=0.674) was not significantly different. No significant differences were observed in patellar shift between walking and stair climbing at either 12 degrees (p=0.093) or 30 degrees (p=0.575) knee flexion. Stair climbing thus leads to more challenging patellofemoral contact mechanics and kinematics than level walking at early knee flexion. The increase in patellofemoral pressure, lateral force distribution and lateral tilt during stair climbing provides a possible biomechanical explanation for the patellofemoral pain frequently experienced during this activity.


Asunto(s)
Fémur/fisiología , Marcha/fisiología , Articulación de la Rodilla/fisiología , Contracción Muscular/fisiología , Músculo Esquelético/fisiología , Rótula/fisiología , Caminata/fisiología , Cadáver , Humanos , Presión , Rango del Movimiento Articular/fisiología , Soporte de Peso/fisiología
20.
Arch Orthop Trauma Surg ; 129(3): 305-9, 2009 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-18704468

RESUMEN

Since biomechanical studies have shown that the medial patellofemoral ligament (MPFL) is the main restraint against lateral patella displacement, reconstruction of the MPFL has become an accepted surgical technique to restore patellofemoral stability. Recently, various procedures have been described that address reconstruction of the medial patellofemoral complex. We present a technique, where the MPFL is reconstructed anatomically to restore physiological kinematics and stability, using a free gracilis tendon autograft.


Asunto(s)
Inestabilidad de la Articulación/cirugía , Ligamentos Articulares/cirugía , Músculo Esquelético/trasplante , Procedimientos Ortopédicos/métodos , Fenómenos Biomecánicos , Humanos , Inestabilidad de la Articulación/fisiopatología , Articulación de la Rodilla , Procedimientos de Cirugía Plástica/métodos , Trasplante Autólogo
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