Urban mobility and health: a multicentric survey conducted in some Italian cities.

INTRODUCTION: Urban and transport planning, environmental exposures, physical activity and human health are strictly linked. The aim of this study was to analyze the determinants of sustainable and active mobility in 4 Italian provinces. MATERIALS AND METHODS: An online multiple-choice survey was administered via Google Form between October 2019 and February 2020. RESULTS: 605 people answered the questionnaire, reporting their mobility practices. The home location did not seem to influence mobility behaviours, with the exception of the greater use of public transport for those who did not live in the province capital. Working or studying in central areas was associated with less use of the car, while not working or studying in the province capital was associated with less use of the motorbike. Women use cars more, and motorcycles/bicycles less. Age and educational level did not seem to influence mobility practices, while being a student compared to a worker was related to greater use of public transport and tendency to walk to the work/study place as well as to lesser car use. DISCUSSION: It is essential that all cities adopt solutions to encourage healthy mobility. The positive relationship between BMI and car use, between good food score and bike use and between frequent light physical activity and healthy mobility indicators confirmed that risk factors are often interconnected and that improving even one single habit could have a positive effect on the others as well. CONCLUSION: An urgent paradigm shift is needed to transform urban areas from agglomerations oriented on motorized transport to ones that rely on active and sustainable mobility, in order to turn cities into places generating wellness and health.

Predicting Response to Neoadjuvant Therapy in Colorectal Cancer Patients the Role of Messenger-and Micro-RNA Profiling.

Colorectal cancer patients' responses to neoadjuvant therapy undergo broad inter-individual variations. The aim of this systematic review is to identify a molecular signature that is predictive of colon cancer downstaging and/or downgrading after neoadjuvant therapy. Among the hundreds analysed in the available studies, only 19 messenger-RNAs (mRNAs) and six micro-RNAs (miRNAs) were differentially expressed in responders versus non-responders in two or more independent studies. Therefore, a mRNA/miRNA signature can be designed accordingly, with limitations caused by the retrospective nature of these studies, the heterogeneity in study designs and the downgrading/downstaging assessment criteria. This signature can be proposed to tailor neoadjuvant therapy regimens on an individual basis.

Analysis of a 3-months measles outbreak in western Liguria, Italy: Are hospital safe and healthcare workers reliable?

BACKGROUND: From January 2017 to June 2018 more than 7000 measles cases were reported in Italy, of which more than 400 among unvaccinated healthcare workers. We described a measles outbreak occurred in Western Liguria, Italy, characterized by a high involvement of healthcare workers and hospital visitors. METHODS: Suspected measles cases and data regarding vaccination status and clinical management of the patients were collected by reviewing 3 different surveillance systems: the routine mandatory notification system, the National Integrated Surveillance System for Measles and Rubella and the regional reference laboratory for measles diagnosis. RESULTS: Thirty-six cases were reported, with a median age of 31 years and >95% in unvaccinated subjects. One death occurred, 15 cases were hospitalized. Hospital transmission was confirmed or suspected in 12 cases; amongst this cases, 5 were healthcare workers (a gynaecologist, an obstetric nurse, a radiologist, a physiotherapist and a nurse working in an infectious disease ward), all certified unvaccinated. Phylogenetic analysis revealed the circulation of a single B3 genotype variant. CONCLUSIONS: Our experience highlighted the key role of nosocomial transmission and the need for targeted strategies, in particular (i) to implement a measles catch-up immunization campaign in susceptible groups, especially in healthcare workers, (ii) to intensify the check of immunisation status of healthcare workers and to offer vaccination for those who need it, (iii) to improve timeliness and completeness of surveillance systems. Efforts are needed to guarantee the safety of the hospital and the reliability of the healthcare workers. Only high vaccination coverage among HCWs can prevent the diffusion of measles in the hospital setting.