RESUMEN
The all solid-state combination of a saturable Bragg mirror for amplitude modulation and a cascaded chi((2)):chi((2)) nonlinearity (phase-mismatched second harmonic crystal) as an axial-mode phase locker for continuous-wave mode locking of large mode area lasers is investigated. The dual-passive mode-locking technique generates extremely stable sub-10ps sech(2) pulses at 76MHz from a ~6W, TEM(00)-mode, diode-pumped, thermal-lens-shaped, Brewster Nd:GdVO(4) laser.
RESUMEN
A straightforward method is presented for generating a stigmatic spherical thermal lens in laser-diode-pumped, Brewster-cut solid-state gain media by shaping the aspect ratio of the elliptical pumped region. Demonstration of this laser head design with Nd:GdVO(4) as the gain medium yields a stable, efficient, high-power (>20W) diode-pumped laser at 1063nm. Analysis of the spatial mode characteristics of a 67cm-long symmetric resonator both confirms the radially symmetric nature of the pump-induced thermal lens and indicates that laser resonators incorporating this head design can readily generate a high spatial beam quality (M(2) < 2).
RESUMEN
Cell surface components of viridans streptococci and enterococci have been shown to stimulate the release of tumor necrosis factor alpha (TNF) and interleukin-6 from monocytes/macrophages. In the sera from 10 patients with subacute enterococcal or streptococcal endocarditis, however, the levels of both cytokines were low or undetectable, with elevated TNF levels on admission in 3 patients with complicated disease. Soluble TNF receptor levels were significantly elevated compared with those of healthy controls. When patients with malaria were used as a control group of acute intravascular infection with high circulating TNF values, the ratio between soluble TNF receptors and TNF on admission was significantly greater in the patients with subacute bacterial endocarditis. Besides different amounts of circulating TNF, enhanced TNF receptor shedding may have an important role in the pathogenesis of subacute versus acute clinical disease following human intravascular infection.