Efficacy and safety of haloperidol for in-hospital delirium prevention and treatment: A systematic review of current evidence.

OBJECTIVE: Haloperidol is generally considered the drug of choice for in-hospital delirium management. We conducted a systematic review to evaluate the evidence for the efficacy and safety of haloperidol for the prevention and treatment of delirium in hospitalized patients. METHODS: PubMed, Embase, Cumulative Index to Nursing and Allied Health (CINAHL), PsycINFO, and the Cochrane Library were systematically searched up to April 21, 2015. We included English full-text randomized controlled trials using haloperidol for the prevention or treatment of delirium in adult hospitalized patients reporting on delirium incidence, duration, or severity as primary outcome. Quality of evidence was graded. Meta-analysis was not conducted because of between-study heterogeneity. RESULTS: Twelve studies met our inclusion criteria, four prevention and eight treatment trials. Methodological limitations decreased the graded quality of included studies. Results from placebo-controlled prevention studies suggest a haloperidol-induced protective effect for delirium in older patients scheduled for surgery: two studies reported a significant reduction in ICU delirium incidence and one study found a significant reduction in delirium severity and duration. Although placebo-controlled trials are missing, pharmacological treatment of established delirium reduced symptom severity. Haloperidol administration was not associated with treatment-limiting side-effects, but few studies used a systematic approach to identify adverse events. CONCLUSION: Although results on haloperidol for delirium management seem promising, current prevention trials lack external validity and treatment trials did not include a placebo arm on top of standard nonpharmacological care. We therefore conclude that the current use of haloperidol for in-hospital delirium is not based on robust and generalizable evidence.

Internet programs targeting multiple lifestyle interventions in primary and secondary care are not superior to usual care alone in improving cardiovascular risk profile: a systematic review.

OBJECTIVE: To review the effects of Internet delivered multiple modifiable lifestyle interventions complementary to usual care on cardiovascular risk factors in the primary and secondary healthcare setting. METHOD: PubMed, EMBASE.com, CINAHL, PsycINFO, and the Cochrane Library were searched up to June 2012 for English written studies that 1) addressed multiple lifestyle interventions, 2) used Internet intervention through websites or email, 3) included at least one usual care group not using Internet, 4) aimed to improve any of cardiovascular risk factors and 5) targeted patients aged 18 or older. RESULTS: Our systematic search yielded 1857 citations of which 9 were selected for this review. Three studies reported significant differences in weight loss in favor of the intervention group and five studies reported non-significant differences between groups. From the 7 studies reporting on blood pressure (BP) measurements, two found significant improvement in favor of the intervention group, while the other studies found no significant differences. Only one study found a significant improvement of LDL-C in the intervention group compared to usual care. Another study found a significant improvement of HDL-C in the usual care group compared to the intervention group. CONCLUSION: The addition of a multiple modifiable lifestyle Internet intervention in primary or secondary care is not superior to usual care with respect to prevention and treatment of cardiovascular risk factors. However, an Internet delivered program does have the potential of being successful in reducing the number of doctor's visits and may therefore be cost-effective when applied in large scale.

An observational cohort study on geriatric patient profile in an emergency department in the Netherlands.

BACKGROUND: Currently, Dutch emergency care systems focus on rapid emergency department (ED) patient management with short completion times, which may not meet specific geriatric care needs. METHODS: Six-week observational study in patients aged ≥70 years, attending the ED of VU University Medical Center (VUmc, Amsterdam, the Netherlands) during weekday peak presentation times (10 AM - 10 PM). RESULTS: During six weeks, a total of 183 patients aged ≥70 years attended the ED, of which 117 (63.9%) presented during weekday peak hours. One hundred patients with a median age of 81 (min-max; 70-97 years) were prospectively observed. The majority presented with fall-related complaints (30%), multiple comorbidities (≥3 in 50.0%) and polymedication (≥5 in 53.7%). Mean ED length of stay was 175.8 (range 20-399) minutes (n=98). Of the patients discharged to their usual residence prior to the ED visit (n=58), 36.2% returned to our ED within 30 days; one in five of these patients had initially presented with a fall. CONCLUSION: In this study, fall-related injuries were the most frequent presenting complaint during weekday peak presentation times in 70-plus patients. Of these, one in five discharged from the ED returned within 30 days. Our emergency care system may not adequately cover comprehensive ED geriatric assessment, or provide sufficient outpatient care after ED home discharge. We believe that EPs should be more aware of the complex problems encountered in acute geriatric patients and address follow-up care pathways such as geriatric outpatient services, more often in frail elderly patients discharged home.

An unusual case of abdominal arterial thrombosis in a young woman using desmopressin.

We report an unusual case of severe abdominal arterial thrombosis in a young woman using oral desmopressin. Only a few cases with cerebrovascular accidents and coronary syndromes have been described so far, which could be attributed to intravenous administration of desmopressin. Because extensive diagnostic and laboratory investigations for (un)common coagulation disorders could not identify an alternative explanation associated with arterial thrombosis, we hypothesise that desmopressin in an oral dose of at least 200 ug once daily must have been sufficient to cause this dramatic vascular complication. Supportive of our hypothesis, we found remarkably high levels of factor VIII activity, Von Willebrand factor (vWF) antigen and vWF ristocetin cofactor activity (268%, 740%, 590% respectively). To the best of the authors' knowledge, this is the first report suggesting a relationship between oral desmopressin use and life-threatening abdominal arterial thrombosis.