RESUMEN
Two new lactone lipids, scoriosin (1) and its methyl ester (2), with a rare furylidene ring joined to a tetrahydrofurandione ring, were isolated from Scorias spongiosa, commonly referred to as sooty mold. The planar structure of these compounds was assigned by 1D and 2D NMR. The conformational analysis of these molecules was undertaken to evaluate the relative and absolute configuration through GIAO NMR chemical shift analysis and ECD calculation. In addition to the potent antimicrobial activities, compound 2 strongly potentiated the activity of amphotericin B against Cryptococcus neoformans, suggesting the potential utility of this compound in combination therapies for treating cryptococcal infections.
Asunto(s)
Antiinfecciosos , Cryptococcus neoformans , Antifúngicos/farmacología , Ascomicetos , Lactonas/farmacología , Lípidos , Estructura MolecularRESUMEN
A new compound, assigned the trivial name bonactin (1), has been isolated from the liquid culture of a Streptomyces sp. BD21-2 obtained from a shallow-water sediment sample collected at Kailua Beach, Oahu, Hawaii. Structure elucidation employed one- and two-dimensional NMR, HRFABMS, IR, and chemical analysis. Bonactin displayed antimicrobial activity against both Gram-positive and Gram-negative bacteria as well as antifungal activity.