[SARS-CoV-2-induced non-bacterial endomyocarditis with the development of acquired heart defects]. / SARS-CoV-2-indutsirovannyi nebakterial'nyi endomiokardit s razvitiem priobretennykh porokov serdtsa.

Patients with damage of the mitral, aortic and tricuspid valves and systolic myocardial dysfunction associated with previous SARS-CoV-2 infection are described. The diagnosis of acquired defect was established in 4 patients based on medical history, electrocardiography, echocardiography, magnetic resonance imaging of the heart, endomyocardial or intraoperative myocardial biopsy, and in one case, autopsy. The study of the myocardium included H&E, Van Gieson staining, immunohistochemical (IHC) study with antibodies to CD3, CD20, CD45, CD68, to the nucleocapsid and Spike proteins of SARS-CoV-2. Previous valve diseases (prolapse, bicuspid aortic valve) served as a background for the development of the defect in 2 patients. In all cases, IHC studies revealed coronavirus proteins, lymphocytic endocarditis and myocarditis, moderate fibrosis, and signs of connective tissue disorganization. High titers of anticardiac antibodies indicated an autoimmune mechanism for carditis. No signs of infective endocarditis or thromboembolic complications were identified in any case. In patients with an unclear nature of valvular heart defects, a previous new coronavirus infection should be identified and taken into account as a possible etiological factor. The simultaneous development of lymphocytic myocarditis significantly increases the risk of surgical intervention on the valves and requires an integrated approach to treatment.

[Thromboembolic mask of severe lymphocytic myopericarditis: possibilities of clinical and morphological diagnostics and complex treatment].

This report presents a clinical case of a 57-year-old female patient who was admitted for dyspnea, productive cough, reduced left ventricular (LV) systolic function, and who had previously undergone thoracocentesis for significant pleural effusion. This case is a unique combination of lymphocytic myocarditis and massive intracardiac and ileo-caval thrombosis. Morphological verification of the diagnosis, that was necessary prior to the administration of immunosuppressive therapy due to the prothrombogenic effect of glucocorticoids, provided a justification for a basis therapy for myocarditis, which significantly improved the patient's condition.

[Сardiac myxoma: challenge in diagnostics. Case report].

Cardiac myxoma is the most common primary benign cardiac tumor (up to 50% of all primary cardiac neoplasms). The implementation of the modern imaging techniques into the clinical practice, particularly, 2D echocardiography, computed tomography and magnetic resonance tomography (MRI) results to the prompt diagnosis of the myxoma. However, the absence of specific clinical features, insufficient awareness of this condition among the physicians along with a rare prevalence, may lead to a misdiagnosis. This case report is notable for the relatively late diagnosis of a giant left atrial myxoma due to a number of circumstances but with successful surgical treatment.

[Justifying hyperbaric oxygenation use for medical correction in individuals working in extreme conditions].

Experimental studies were conducted to justify possibility of hyperbaric oxygenation to correct functional state in individuals working in extreme conditions. Studies were aimed to determine stress resistance in apparently healthy individuals, to choose hyperbaric oxygenation method and mode.

[The activity of the ad hoc commission on "The Problems of Human Protection under Extreme Conditions": results and prospects]. / Itogi i perspektivy deiatel'nosti problemnoi komissii "Problemy zashchity cheloveka v ékstremal'nykh usloviiakh".

The paper summarizes the results of 10-year activity of the ad hoc commission on "The Problems of Human Protection under Extreme Conditions" of the Interdepartmental Scientific Council on Human Ecology and Environmental Hygiene, Russian Academy of Medical Sciences. It shows the work of the Commission on Planning, Organization, and Coordination of Researches in the Development and Introduction of New Human Protective Agents and Means from Exposures to Chemical, Physical, and Biological Agents under Extreme Conditions. The prospects of the Commission's work have been defined for the coming 5 years, by taking into account the priority lines of development of science, technology, engineering in the Russian Federation.

[Design of medical facilities for the saving of persons exposed to low temperatures]. / Razrabotka mediko-tekhnicheskikh sredstv dlia spaseniia liudei, podvergshikhsia vozdeistviiu nizkikh temperatur.

The paper describes medical facilities for saving victims of general cooling. Physiological ways of recovery of the thermal status of individuals exposed to general cooling are substantiated. A physiological rationale is presented for the design of engineering aids to prevent overcooling in persons who do their work in cold. The specifications of electric heating cloth used in the design of these medical rescue facilities are characterized.

[The organization of individual human protection in emergencies]. / Organizatsiia individual'noi zashchity cheloveka pri chrezvychainykh situatsiiakh.

Individual protection should be considered as a unity of organizational, social, medical, ergonomic and technical measures. The authors characterize all components of the unity.

[Preparation of fiber materials containing both the immobilized proteolytic enzyme and antimicrobial substance, and study of their properties]. / Poluchenie voloknistykh materialov, soderzhashchikh odnovremenno immobilizirovannyi proteoliticheskii ferment i antimikrobnoe veshchestvo, i issledovanie ikh svoistv.

Properties of joint immobilization of a proteolytic enzyme (terrilytin, trypsin, collytin, or protease C) and an anti-microbe compound to cellulose copolymer containing carboxyl groups were investigated. It was established that the molecule of anti-microbe substance containing a few base groups enhanced stability of the enzyme immobilized, most likely due to additional fixation of the enzyme macromolecule. Changes in activity of the materials containing both protease and anti-microbe compound were studied upon gamma-sterilization and subsequent prolonged storage. The materials with combined biological action were demonstrated to accelerate markedly wound cleansing and healing.

[Use of products made of antimicrobial materials in the prevention of foot mycoses]. / Primenenie izdelii iz antimikrobnykh materialov dlia profilaktiki mikozov stop.

Field trials were conducted to evaluate effectiveness of mycoses prophylaxis gained by use of antimicrobial insoles and foot-binding with fungicide agents. The trials involved 100 novice soldiers. Bacteriology and bacterioscopy studies diagnosed 47 soldiers as having subclinical mycosis of feet. Using antimicrobial insoles and foot-binding caused considerably lower occurrence of pathogenic fungi in the skin samples; using antimicrobial insoles with regular foot-binding resulted in no changes of the skin microflora. The authors recommend wide application of antimicrobial stuff with fungicide agents for prophylaxis of feet mycosis.

[The use of individual protective devices for decreasing the microbial contamination of the inhaled air]. / Primenenie sredstv individual'noi zashchity dlia snizheniia mikrobnoi obsemenennosti vdykhaemogo vozdukha.

The work was aimed to justify application of gas masks and respirators with autonomous air source fo lower bacterial contamination of inhaled air. The studies also covered possible catch of bacteria by cotton and filters FPP-15-1.5, those composed of antimicrobial materials, containing furagin or copper ions. As the studies proved, for lower bacterial contaminations of inhaled air one can apply autonomous air source apparatus with filters made of Petrianov tissue, antimicrobial tissue (containing furagin or copper ions), as they reduce fungal content of the air. Such filters are self-disinfecting, but do not influence total contamination of the air.

[Use of insoles made of antimicrobial materials as prophylactic means in foot mycoses]. / Primenenie stelek iz antimikrobnykh materialov v kachestve profilakticheskogo sredstva pri mikozakh stop.

Stationary dermatologic examination covered 32 sufferers from epidermophytosis of soles, who used 3 types of antimicrobial insoles chosen through laboratory investigations. Clinical trials proved that antimicrobial insoles, if applied during 2 weeks, result in considerably decreased occurrence of causal fungus in the patients' surface skin scarring. The results proved fungicidal and bactericidal activity of insoles including furagin, nitrofurilacroleine, polyhexamethylene guanidine, so such insoles could be recommended as prophylactic measure for mycoses of soles.

[Experimental rationale for the use of drugs to increase the resistance of the human body to the combined action of carbon monoxide and hyperthermia]. / Eksperimental'noe obosnovanie primeneniia farmakologicheskikh preparatov dlia povysheniia ustoichivosti organizma cheloveka k sochetannomu vozdeistviiu oksida ugleroda i gipertermii.

A group of volunteers was exposed to coaction of carbon dioxide (concentration 300 mg/cu m) and heating microclimate (ambient temperature +50 +/- 2 degrees C, relative humidity 20 +/- 5%), simultaneously they received one of the medicines: placebo, bemitil (0.5 g), bromantane (0.25 g) or bemitil (0.5 g) combined with bromantane (0.25 g). Bromantane (0.25 g) or bemitil (0.5 g) combined with bromantane (0.25 g) were proved to be the most effective method to increase stability of the human body against co-action of carbon dioxide and heating microclimate.

[Utilization of individual protective devices with autonomic air supply for work with hazardous materials ]. / Primenenie sredstv individualnoi zashchity s avtonomnymi istochnikami vozdukhosnabzheniia dla raboty s vrednymi veshchestvami.

An application of individual protective means (IPM) with the autonomic air supply has considerable promise for protecting respiratory organs and eyes in hazardous conditions. The main advantage of such devices is that the respiratory zone has the forced supply with the cleansed air. Biophysical studies showed that such IPM don't harm the functional status and capacity for work in human doing the medium-difficult physical work during 8 hours and can be recommended for the application in mines.

[Individual protection aids for saving people during a fire]. / Sredstva individual'noi zashchity dlia spaseniia liudei vo vremia pozhara.

All existing individual protective means can not be applied to the life saving and the mall evacuation of people from fire due to their technical complexity and inadequate protective efficiency. The research work carried out by the authors served to produce a crucially new type of physiologically acceptable individual protective means against burning products and high environmental temperature.

[Use of bemitil for increasing the resistance of the human body to combined effects of carbon monoxide and heating microclimate]. / Ispol'zovanie bemitila dlia povysheniia ustoichivosti organizma cheloveka k sochetannomu vozdeistviiu oksida ugleroda i nagreva- iushchego mikroklimata

Basing on experimental data, it was established that single administration of 0.5 mg bemitil increased human resistance to carbon oxide in concentration 300 mg/m3. The use of bemitil optimized human body state in the conditions of the complex influence of carbon oxide and extreme heating microclimate.