Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 54
Filtrar
1.
NMR Biomed ; 22(2): 207-12, 2009 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-19130495

RESUMEN

Degeneration of the dopaminergic neurons of the substantia nigra pars compacta in Parkinson's disease induces an abnormal activation of the glutamatergic neurotransmission system within the basal ganglia network and related structures. The aim of this study was to use proton MRS to show metabolic changes in the striatum of 6-hydroxydopamine-lesioned rats, a rodent animal model of Parkinson's disease. Animals were examined before and after extensive lesioning of the nigral dopaminergic neurons and after acute administration of L-3,4-dihydroxyphenylalanine. No significant alterations in glutamate concentrations, assessed by the MR signal dominated by glutamate with minor contributions from glutamine and gamma-aminobutyric acid, could be measured. The total choline/total creatine ratio was found to be reduced in the striatum of the ipsilateral hemisphere.


Asunto(s)
Cuerpo Estriado/metabolismo , Modelos Animales de Enfermedad , Espectroscopía de Resonancia Magnética/métodos , Enfermedad de Parkinson/metabolismo , Animales , Humanos , Masculino , Protones , Ratas , Ratas Sprague-Dawley
2.
J Radiol ; 87(6 Pt 1): 607-17, 2006 Jun.
Artículo en Francés | MEDLINE | ID: mdl-16788535

RESUMEN

In the last decade, functional MRI (fMRI) has become one of the most widely used functional imaging technique in neurosciences. However, its clinical applications remain limited. Despite methodological and practical issues, fMRI data has been validated by different techniques (magnetoencephalography, Wada test, electrical and magnetic stimulations, and surgical resections). In neurosurgical practice, fMRI can identify eloquent areas involved in motor and language functions, and may evaluate characteristics of postoperative neurological deficit including its occurrence, clinical presentation and duration. This may help to inform patients and to prepare postoperative care. fMRI may also identify epileptic foci. In neurological practice, fMRI may help to determine prognosis of recovery after stroke, appropriate medication, and rehabilitation. fMRI may help to identify patients at risk of developing Alzheimer disease. Finally, cerebrovascular reactivity imaging is an interesting approach that might provide new radiological insights of vascular function.


Asunto(s)
Encefalopatías/diagnóstico , Imagen por Resonancia Magnética , Encéfalo/metabolismo , Encefalopatías/metabolismo , Humanos , Imagen por Resonancia Magnética/métodos , Oxígeno/sangre
3.
Brain Res ; 1085(1): 149-62, 2006 Apr 26.
Artículo en Inglés | MEDLINE | ID: mdl-16574082

RESUMEN

The cognitive mechanisms involved in polysyllabic pseudo-word processing -- and their neurobiological correlates -- were studied through the analysis of length effects on French words and pseudo-words in reading and lexical decision. Connectionist simulations conducted on the ACV98 network paralleled the behavioral data in showing a strong length effect on naming latencies for pseudo-words only and the absence of length effect for both words and pseudo-words in lexical decision. Length effects in reading were characterized at the neurobiological level by a significant and specific activity increase for pseudo-words as compared to words in the right lingual gyrus (BA 19), the left superior parietal lobule and precuneus (BA7), the left middle temporal gyrus (BA21) and the left cerebellum. The behavioral results suggest that polysyllabic pseudo-word reading mainly relies on an analytic procedure. At the biological level, additional activations in visual and visual attentional brain areas during long pseudo-word reading emphasize the role of visual and visual attentional processes in pseudo-word reading. The present findings place important constraints on theories of reading in suggesting the involvement of a serial mechanism based on visual attentional processing in pseudo-word reading.


Asunto(s)
Mapeo Encefálico , Encéfalo/irrigación sanguínea , Imagen por Resonancia Magnética , Lectura , Semántica , Conducta Verbal/fisiología , Adulto , Encéfalo/fisiología , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador/métodos , Masculino , Oxígeno/sangre , Procesamiento de Texto/métodos
4.
MAGMA ; 17(3-6): 313-6, 2004 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-15580376

RESUMEN

Vessel size index (VSI) measurements have been validated on rats bearing a glioma with high doses of contrast agent. The aim of this study was to evaluate the impact of using a reduced dose of contrast agent, necessary for clinical trials. Experiments were performed on rats at three doses of AMI-227 and clearly show higher VSI values at lower doses, whatever the region of interest (contralateral, peritumoral and intratumoral tissue). These results are in good correlation with Monte-Carlo simulations on healthy brain and suggest that only relative values can be obtained at clinical contrast agent doses and magnetic fields.


Asunto(s)
Neoplasias Encefálicas/irrigación sanguínea , Neoplasias Encefálicas/patología , Hierro/administración & dosificación , Imagen por Resonancia Magnética/métodos , Microcirculación/patología , Neovascularización Patológica/patología , Óxidos/administración & dosificación , Animales , Línea Celular Tumoral , Medios de Contraste/administración & dosificación , Cuerpo Estriado/irrigación sanguínea , Cuerpo Estriado/patología , Dextranos , Relación Dosis-Respuesta a Droga , Óxido Ferrosoférrico , Glioma/irrigación sanguínea , Glioma/patología , Aumento de la Imagen/métodos , Nanopartículas de Magnetita , Masculino , Ratas , Ratas Wistar , Reproducibilidad de los Resultados , Sensibilidad y Especificidad
5.
Neuroimage ; 21(3): 801-17, 2004 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-15006647

RESUMEN

We measured the timing of activity in distinct functional areas of the human visual cortex after onset of a visual pattern. This is not possible with visual evoked potentials (VEPs) or magnetic fields alone, and direct combination of functional magnetic resonance imaging (fMRI) with electromagnetic data has turned out to be difficult. We tested a relatively new approach, where both position and orientation of the active cortex was given to the VEP source model. Subjects saw the same visual patterns flashed ON and OFF, both when recording VEPs and fMRI responses. We identified the positions and orientations of the activated cortex in four retinotopic areas in each individual, and the corresponding dipoles were seeded to model the individual evoked potential data. Unexplained variance, comprising signals from other areas, was inversely modeled. Despite the partially a priori fixed model and optimized signal-to-noise ratio of VEP data, full separation of retinotopic areas was only seldom possible due to crosstalk between the adjacent sources, but separation was usually possible between areas V1 and V3/V3a. Whereas the latencies generally followed the hierarchical organization of cortical areas (V1-V2-V3), with around 25 ms between the strongest responses, an early activation emerged 10-20 ms after V1, close to the temporo-occipital junction (LO/V5) and with an additional 20-ms latency in the corresponding region of the opposite hemisphere. Our approach shows that it is feasible to directly seed information from fMRI to electromagnetic source models and to identify the components and dynamics of VEPs in different retinotopic areas of a human individual.


Asunto(s)
Potenciales Evocados Visuales/fisiología , Corteza Visual/fisiología , Adulto , Mapeo Encefálico , Electroencefalografía , Femenino , Humanos , Individualidad , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Modelos Neurológicos , Lóbulo Occipital/fisiología , Estimulación Luminosa , Retina/fisiología , Campos Visuales/fisiología , Vías Visuales/fisiología
6.
Neuroimage ; 21(3): 818-28, 2004 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-15006648

RESUMEN

While it is generally believed that interactions across long distances in the visual field occur only in the higher-order cortical areas, other results suggest that such interactions are processed very early. In the preceding paper, we identified the latencies within a subset of cortical areas in the human visual system. In the present study, we test in which areas and at which latencies the responses to two visual patterns start interacting. We used functional magnetic resonance imaging directly combined with visual-evoked potential source analysis. Interactions appeared first anterolaterally to the retinotopic areas, at 80 ms for two stimuli presented in the left lower visual quadrant and at 100 ms for symmetrical stimulation of both lower quadrants. In the lateral occipital-V5 region (LOV5), two patterns presented simultaneously in one quadrant elicited a response with shorter latency and infra-linear addition of the amplitudes compared with the patterns presented separately. For bilateral stimulation, the timing of the LOV5 response coincided with the response to contralateral stimulation alone. Other visual areas showed interactions appearing later than within LOV5: starting at 150 ms in V1, at 120 ms in V3-V3a for the left visual hemifield stimulation and at 160 ms for both visual hemifields stimulation. Our data show that distinct patterns in the visual field interact first in LOV5, suggesting that this region must be the first to pool spatial information across the whole visual field.


Asunto(s)
Corteza Visual/fisiología , Campos Visuales/fisiología , Adulto , Mapeo Encefálico , Potenciales Evocados Visuales/fisiología , Femenino , Lateralidad Funcional/fisiología , Humanos , Individualidad , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Modelos Neurológicos , Percepción de Movimiento/fisiología , Estimulación Luminosa , Retina/fisiología , Percepción Visual/fisiología
7.
Cereb Cortex ; 13(8): 837-44, 2003 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-12853370

RESUMEN

Contingencies between objects and people can be mechanical or intentional-social in nature. In this fMRI study we used simplified stimuli to investigate brain regions involved in the detection of mechanical and intentional contingencies. Using a factorial design we manipulated the 'animacy' and 'contingency' of stimulus movement, and the subject's attention to the contingencies. The detection of mechanical contingency between shapes whose movement was inanimate engaged the middle temporal gyrus and right intraparietal sulcus. The detection of intentional contingency between shapes whose movement was animate activated superior parietal networks bilaterally. These activations were unaffected by attention to contingency. Additional regions, the right middle frontal gyrus and left superior temporal sulcus, became activated by the animate-contingent stimuli when subjects specifically attended to the contingent nature of the stimuli. Our results help to clarify neural networks previously associated with 'theory of mind' and agency detection. In particular, the results suggest that low-level perception of agency in terms of objects reacting to other objects at a distance is processed by parietal networks. In contrast, the activation of brain regions traditionally associated with theory of mind tasks appears to require attention to be directed towards agency and contingency.


Asunto(s)
Mapeo Encefálico/métodos , Encéfalo/fisiología , Percepción de Movimiento/fisiología , Estimulación Luminosa/métodos , Adolescente , Adulto , Femenino , Humanos , Masculino , Estadísticas no Paramétricas
8.
Eur J Radiol ; 46(2): 139-46, 2003 May.
Artículo en Inglés | MEDLINE | ID: mdl-12714230

RESUMEN

The aim of this fMRI study was to evaluate the motor reorganization (cerebral plasticity) and the risk of motor deficit in patients presenting with tumors and vascular malformations, within the framework of their pre-surgical planning. Functional MR imaging data was obtained from 17 patients. Ten patients (seven with tumors and three with vascular malformations) presented with motor reorganization. The results of the present study suggest that the evaluation of the cerebral reorganization is an essential step in predicting the risk of motor deficit in patients having surgical indication for treatment. Furthermore, the cerebral reorganization constitutes an important factor for surgical decision.


Asunto(s)
Mapeo Encefálico , Neoplasias Encefálicas/diagnóstico , Glioma/diagnóstico , Malformaciones Arteriovenosas Intracraneales/diagnóstico , Actividad Motora/fisiología , Corteza Motora/fisiología , Adulto , Neoplasias Encefálicas/fisiopatología , Neoplasias Encefálicas/cirugía , Femenino , Glioma/fisiopatología , Glioma/cirugía , Humanos , Procesamiento de Imagen Asistido por Computador , Malformaciones Arteriovenosas Intracraneales/fisiopatología , Malformaciones Arteriovenosas Intracraneales/cirugía , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Cuidados Preoperatorios
9.
Neuroimage ; 17(4): 1665-83, 2002 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-12498741

RESUMEN

fMRI retinotopic mapping provides detailed information about the correspondence between the visual field and its cortical representation in the individual subject. Besides providing for the possibility of unambiguously localizing functional imaging data with respect to the functional architecture of the visual system, it is a powerful tool for the investigation of retinotopic properties of visual areas in the healthy and impaired brain. fMRI retinotopic mapping differs conceptually from a more traditional volume-based, block-type, or event-related analysis, in terms of both the surface-based analysis of the data and the phase-encoded paradigm. Several methodological works related to fMRI retinotopic mapping have been published. However, a detailed description of all the methods involved, discussing the steps from stimulus design to the processing of phase data on the surface, is still missing. We describe here step by step our methodology for the complete processing chain. Besides reusing methods proposed by other researchers in the field, we introduce original ones: improved stimuli for the mapping of polar angle retinotopy, a method of assigning volume-based functional data to the surface, and a way of weighting phase information optimally to account for the SNR obtained locally. To assess the robustness of these methods we present a study performed on three subjects, demonstrating the reproducibility of the delineation of low order visual areas.


Asunto(s)
Mapeo Encefálico/métodos , Procesamiento de Imagen Asistido por Computador/métodos , Imagenología Tridimensional/métodos , Imagen por Resonancia Magnética/métodos , Retina/fisiología , Visión Ocular/fisiología , Corteza Visual/fisiología , Algoritmos , Humanos , Neuronas/fisiología , Consumo de Oxígeno/fisiología , Reproducibilidad de los Resultados , Retina/anatomía & histología , Corteza Visual/anatomía & histología , Campos Visuales/fisiología , Vías Visuales/anatomía & histología , Vías Visuales/fisiología
10.
Am J Gastroenterol ; 97(3): 654-61, 2002 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-11926209

RESUMEN

OBJECTIVES: In healthy subjects, the neural correlates of visceral pain bear much similarity with the correlates of somatic pain. In patients with irritable bowel syndrome, the central nervous system is believed to play a strong modulatory or etiological role in the pathophysiology of the disease. We hypothesize that this role must be reflected in aberrations of central functional responses to noxious visceral stimulation in these patients. To verify this hypothesis, we have induced transient rectal pain in patients and assessed the functional responses of the brain by means of functional magnetic resonance imaging. METHODS: Twelve right-handed patients (11 female) were examined. Functional imaging (1.5 T) was performed following a block paradigm, alternating epochs with and without noxious stimulation of the rectum. Rectal pain was induced by inflating a latex balloon. Whole-brain coverage was achieved by means of echo-planar magnetic resonance acquisition. RESULTS: A strong variability of the individual responses to rectal pain was found in patients with irritable bowel syndrome. Significant activations were found in only two patients, and group analysis did not reveal significant activations. In contrast, all patients exhibited significant deactivations. Group analysis revealed significant deactivations within the right insula, the right amygdala, and the right striatum. CONCLUSIONS: This study reveals aberrant functional responses to noxious rectal stimulation in patients with irritable bowel syndrome. Those results add grounds to the hypothesis that the central nervous system plays a significant role in the pathophysiology of this syndrome.


Asunto(s)
Sistema Nervioso Central/patología , Sistema Nervioso Central/fisiopatología , Enfermedades Funcionales del Colon/patología , Enfermedades Funcionales del Colon/fisiopatología , Imagen por Resonancia Magnética , Dolor/patología , Dolor/fisiopatología , Enfermedades del Recto/patología , Enfermedades del Recto/fisiopatología , Adulto , Anciano , Enfermedades Funcionales del Colon/complicaciones , Femenino , Humanos , Masculino , Persona de Mediana Edad , Conducción Nerviosa/fisiología , Dolor/etiología , Umbral del Dolor/fisiología , Enfermedades del Recto/etiología , Recto/patología , Recto/fisiopatología , Umbral Sensorial
11.
Neuroreport ; 12(17): 3741-6, 2001 Dec 04.
Artículo en Inglés | MEDLINE | ID: mdl-11726785

RESUMEN

Detection of the causal relationships between events is fundamental for understanding the world around us. We report an event-related fMRI study designed to investigate how the human brain processes the perception of mechanical causality. Subjects were presented with mechanically causal events (in which a ball collides with and causes movement of another ball) and non-causal events (in which no contact is made between the balls). There was a significantly higher level of activation of V5/MT/MST bilaterally, the superior temporal sulcus bilaterally and the left intraparietal sulcus to causal relative to non-causal events. Directing attention to the causal nature of the stimuli had no significant effect on the neural processing of the causal events. These results support theories of causality suggesting that the perception of elementary mechanical causality events is automatically processed by the visual system.


Asunto(s)
Atención/fisiología , Corteza Cerebral/fisiología , Cognición/fisiología , Potenciales Evocados/fisiología , Percepción de Movimiento/fisiología , Vías Visuales/fisiología , Adulto , Conducta/fisiología , Corteza Cerebral/anatomía & histología , Femenino , Lateralidad Funcional/fisiología , Humanos , Imagen por Resonancia Magnética , Masculino , Lóbulo Parietal/anatomía & histología , Lóbulo Parietal/fisiología , Estimulación Luminosa , Desempeño Psicomotor/fisiología , Corteza Visual/anatomía & histología , Corteza Visual/fisiología , Vías Visuales/anatomía & histología
12.
Epileptic Disord ; 3(3): 117-24, 2001 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-11679302

RESUMEN

This study assesses the interest of a simple fMRI rhyme detection paradigm to determine hemispheric predominance for language in epileptic patients. Nineteen patients were examined. The findings derived from the fMRI examinations were compared with those obtained on the same patients using the Wada test, stereotactic intracerebral EEG stimulations and recordings, and/or video-EEG recordings. For the seventeen patients for whom language dominance could be assessed by means of at least one of the latter procedures, the fMRI examination provided concordant results in sixteen. In two patients, the hemispheric predominance for language could only be determined by fMRI. Nine patients underwent surgery subsequent to the fMRI examination. None of them exhibited any aphasic problems following surgery. The rhyme detection task used in the fMRI examination generates robust responses in the language areas, permits easy monitoring of the patient's task performance and can be easily undertaken by the epileptic patients. Thus, this study demonstrates that the fMRI rhyme detection paradigm is particularly well-suited for determining hemispheric language predominance in epileptic candidates for surgery.


Asunto(s)
Dominancia Cerebral/fisiología , Epilepsia/diagnóstico , Pruebas del Lenguaje , Imagen por Resonancia Magnética , Aprendizaje por Asociación de Pares/fisiología , Lectura , Adulto , Mapeo Encefálico , Corteza Cerebral/fisiopatología , Corteza Cerebral/cirugía , Epilepsia/fisiopatología , Epilepsia/cirugía , Femenino , Hipocampo/fisiopatología , Hipocampo/cirugía , Humanos , Masculino , Persona de Mediana Edad , Pronóstico , Semántica
13.
Neuroimage ; 13(5): 775-85, 2001 May.
Artículo en Inglés | MEDLINE | ID: mdl-11304074

RESUMEN

Perception of biological motions plays a major adaptive role in identifying, interpreting, and predicting the actions of others. It may therefore be hypothesized that the perception of biological motions is subserved by a specific neural network. Here we used fMRI to verify this hypothesis. In a group of 10 healthy volunteers, we explored the hemodynamic responses to seven types of visual motion displays: drifting random dots, random dot cube, random dot cube with masking elements, upright point-light walker, inverted point-light walker, upright point-light walker display with masking elements, and inverted point-light walker display with masking elements. A gradient in activation was observed in the occipitotemporal junction. The responses to rigid motion were localized posteriorly to those responses elicited by nonrigid motions. Our results demonstrate that in addition to the posterior portion of superior temporal sulcus, the left intraparietal cortex is involved in the perception of nonrigid biological motions.


Asunto(s)
Encéfalo/fisiología , Imagen por Resonancia Magnética , Percepción de Movimiento/fisiología , Adulto , Encéfalo/irrigación sanguínea , Mapeo Encefálico , Dominancia Cerebral/fisiología , Femenino , Humanos , Aumento de la Imagen , Procesamiento de Imagen Asistido por Computador , Masculino , Lóbulo Occipital/irrigación sanguínea , Lóbulo Occipital/fisiología , Enmascaramiento Perceptual/fisiología , Valores de Referencia , Flujo Sanguíneo Regional/fisiología , Lóbulo Temporal/irrigación sanguínea , Lóbulo Temporal/fisiología , Vías Visuales/irrigación sanguínea , Vías Visuales/fisiología
14.
Cereb Cortex ; 10(7): 663-70, 2000 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-10906313

RESUMEN

Identifying the cortical areas activated by illusory contours provides valuable information on the mechanisms of object perception. We applied functional magnetic resonance imaging to identify the visual areas of the human brain involved in the perception of a moving Kanizsa-type illusory contour. Our results indicate that, in addition to other cortical regions, areas V5 and V1 are activated. Activity in area V1 was particularly prominent.


Asunto(s)
Mapeo Encefálico , Percepción de Forma/fisiología , Ilusiones Ópticas/fisiología , Corteza Visual/fisiología , Adulto , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Estimulación Luminosa
15.
Radiology ; 213(3): 785-93, 1999 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-10580954

RESUMEN

PURPOSE: To assess the usefulness of the 0.9-ppm peak from amino acids (-CH3 moieties from valine, leucine, and isoleucine) for the differentiation of brain abscesses and tumors at in vivo hydrogen 1 magnetic resonance (MR) spectroscopy. MATERIALS AND METHODS: Amino acid concentrations were determined in vitro in 13 purulent samples from brain and nonbrain tissues and in nine aseptic fluids from necrotic brain tumors at two-dimensional (2D) 1H MR spectroscopy and liquid chromatography. Thirty-four patients with cystic intracerebral mass lesions (28 tumors, six abscesses) were examined at 1H MR spectroscopy in vivo. RESULTS: Amino acids were identified in vitro in both purulent and aseptic samples. Amino acid concentrations measured in the aseptic fluids at both liquid chromatography and 2D MR spectroscopy were far below the detection threshold of in vivo 1H MR spectroscopy. Quantitative results obtained at 2D MR spectroscopy showed no overlap in the ranges of amino acid concentrations in purulent and aseptic samples. In vivo, the proton spectra obtained with a 136-msec echo time (TE) revealed amino acids (inverted peak at 0.9 ppm) in only the abscesses. CONCLUSION: The detection of amino acid resonance at 0.9 ppm at in vivo 1H MR spectroscopy (136-msec TE) is a promising tool for distinguishing bacterial abscesses and cystic brain tumors.


Asunto(s)
Infecciones Bacterianas/diagnóstico , Absceso Encefálico/diagnóstico , Neoplasias Encefálicas/diagnóstico , Isoleucina/análisis , Leucina/análisis , Espectroscopía de Resonancia Magnética , Valina/análisis , Adolescente , Adulto , Anciano , Encéfalo/patología , Diagnóstico Diferencial , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Necrosis , Fantasmas de Imagen , Sensibilidad y Especificidad
16.
AJNR Am J Neuroradiol ; 20(10): 1920-4, 1999.
Artículo en Inglés | MEDLINE | ID: mdl-10588119

RESUMEN

BACKGROUND AND PURPOSE: Although the central processing of somatic pain has been dealt with in numerous brain imaging studies, the neural correlates of visceral pain have received much more limited attention. Our goal was to assess the feasibility of detecting brain activation patterns induced by rectal pain by means of functional MR imaging. We hypothesized that the cerebral processing of rectal pain would exhibit strong similarities with the central processing of somatic pain. METHODS: Functional MR imaging data were obtained from eight healthy subjects. A block paradigm was applied. Rectal pain was induced by inflating a latex balloon catheter that had been inserted into the rectum. Functional responses were established by means of cross-correlation analysis. RESULTS: Activation was detected within the anterior cingulate gyrus, the prefrontal cortex, the insular cortex, the sensory-motor cortex, the inferior parietal lobule, the posterior cingulate gyrus, and the visual cortex. CONCLUSION: Functional MR imaging of visceral pain is feasible in healthy subjects. The activation patterns observed in this study support the hypothesis that the cerebral processing of visceral pain involves multiple components, similar to the central processing of somatic pain. Our results constitute a first step toward the identification of possible aberrations in the activation patterns of patients suffering from visceral hypersensitivity.


Asunto(s)
Corteza Cerebral/fisiopatología , Giro del Cíngulo/fisiopatología , Imagen por Resonancia Magnética , Dolor/fisiopatología , Recto/inervación , Adulto , Mapeo Encefálico , Potenciales Evocados Somatosensoriales/fisiología , Femenino , Humanos , Masculino , Valores de Referencia
18.
NMR Biomed ; 12(5): 293-8, 1999 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-10484818

RESUMEN

Hemispheric language dominance (HLD) has been determined by means of functional MRI (fMRI) using a simple, inner speech, word fluency paradigm. During the task periods, subjects perform mental imagery of visual scenes and generate silently the nouns of all objects visualized. During the control periods, subjects attend to the scanner noise. Activated areas have been identified by means of cross-correlation analysis. HLD indices have been determined by comparing the number of activated pixels detected in both hemispheres within predefined cortical areas (Brodmann areas 6, 9, 10, 39, 40 and 44-47). The paradigm has been assessed on 10 healthy, right-handed volunteers. A volume 35 mm thick, centered on the inferior frontal gyrus, was imaged. A conventional GRE MR sequence was used on a 1.5 T clinical MR scanner. HLD indices were compared with those determined for overt speech. Robust fMRI responses were obtained. HLD indices indicated left hemispheric language dominance for all subjects examined. They correlated well with those obtained for overt speech (R(2) = 0.93, regression coefficient = 0.998, with p < 10(-4)). Thus, an inner speech paradigm based on visual imagery is well adapted for assessment of HLD by means of fMRI.


Asunto(s)
Corteza Cerebral/anatomía & histología , Corteza Cerebral/fisiología , Dominancia Cerebral/fisiología , Lenguaje , Imagen por Resonancia Magnética/métodos , Adulto , Humanos , Masculino
19.
NMR Biomed ; 12(2): 107-14, 1999 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-10392807

RESUMEN

In this study, phase-contrast MR techniques are applied in order to measure the blood flow changes induced by a motor task in a large superficial vein draining the motor cortex. The measurements were applied to six healthy volunteers, in motor rest conditions and during performance of a motor task. The latter consisted of sequential finger-to-thumb opposition. The task was actually executed and mentally simulated. Significant blood flow increases were found when changing from from mental simulation to actual execution of the motor task (increases ranging between 1.6 and 10.3 ml/min, i.e. 9% and 45%, respectively) and from resting conditions to actual execution of the motor task (increases ranging between 1.7 and 14.0 ml/min, i.e. 32% and 72%, respectively).


Asunto(s)
Circulación Cerebrovascular/fisiología , Imagen por Resonancia Magnética/métodos , Corteza Motora/irrigación sanguínea , Adulto , Velocidad del Flujo Sanguíneo , Venas Cerebrales/fisiología , Femenino , Humanos , Masculino , Reproducibilidad de los Resultados
20.
Neuroreport ; 10(6): 1373-8, 1999 Apr 26.
Artículo en Inglés | MEDLINE | ID: mdl-10363956

RESUMEN

Functional magnetic resonance imaging (fMRI) was applied to determine the involvement of the angular gyri in the processing of categorical and coordinate spatial relations. In a categorical task, subjects were asked to judge whether a dot was presented above or below a horizontal line. In a coordinate task, they were asked to judge whether or not the distance between the dot and the bar was within a reference distance. Results showed stronger activation of the left than of the right angular gyrus in the categorical task, and stronger activation, initially, of the right than of the left angular gyrus in the coordinate task. In addition, in the latter task, the involvement of the right angular gyrus decreased with practice while that of the left angular gyrus increased. These results are interpreted in terms of the development of new categorical representations with practice in the coordinate task.


Asunto(s)
Mapeo Encefálico , Lateralidad Funcional/fisiología , Lóbulo Parietal/fisiología , Desempeño Psicomotor/fisiología , Percepción Espacial/fisiología , Adulto , Humanos , Imagen por Resonancia Magnética/métodos , Masculino , Estimulación Luminosa , Campos Visuales/fisiología
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA