Response of the alanine/ESR dosimeter to radiation from an Ir-192 HDR brachytherapy source.

The response of the alanine dosimeter to radiation from an Ir-192 source with respect to the absorbed dose to water, relative to Co-60 radiation, was determined experimentally as well as by Monte Carlo simulations. The experimental and Monte Carlo results for the response agree well within the limits of uncertainty. The relative response decreases with an increasing distance between the measurement volume and the source from approximately 98% at a 1 cm distance to 96% at 5 cm. The present data are more accurate, but agree well with data published by Schaeken et al (2011 Phys. Med. Biol. 56 6625-34). The decrease of the relative response with an increasing distance that had already been observed by these authors is confirmed. In the appendix, the properties of the alanine dosimeter with respect to volume and sensitivity corrections are investigated. The inhomogeneous distribution of the detection probability that was taken into account for the analysis was determined experimentally.

Calorimetric determination of the absorbed dose to water for medium-energy x-rays with generating voltages from 70 to 280 kV.

For medium energy x-rays produced with tube voltages from 70 to 280 kV, the absorbed dose to water, D(w), has been determined by means of water calorimetry with relative standard uncertainties ranging from 0.45% to 0.98% at 280 and 70 kV. The results were confirmed by Monte Carlo calculations, in which the ratios of D(w) at 5 cm depth in a reference water phantom to the air kerma free in air, K(a), at the same point in space were compared to the corresponding ratios determined experimentally. The general agreement between measurement and calculation was better than 1%. These results confirm earlier investigations in which the absorbed dose to graphite was determined by means of a graphite extrapolation chamber. For the Monte Carlo calculations, an attempt was made to present a complete uncertainty budget, taking into account type B contributions also.

Extension of the range of definition of the practical peak voltage up to 300 kV.

The practical peak voltage (PPV) was introduced with special emphasis being placed on the X-ray tube voltage range pertinent to diagnostic radiology, i.e. from 20 kV to 150 kV. In this paper, an extension of the range of definition of the PPV up to X-ray tube voltages of 300 kV is presented. This is realized by combining the weighting function derived for the field of diagnostic radiology with a newly derived one that covers the voltage range from 150 kV to 300 kV.

Measurement of the x-ray mass energy-absorption coefficient of air using 3 keV to 10 keV synchrotron radiation.

For the first time absolute photon mass energy-absorption coefficients of air in the energy range 3 keV to 10 keV have been measured with relative standard uncertainties less than 1%, significantly smaller than those of up to 5% assumed hitherto for calculated data. Monochromatized synchrotron radiation was used to measure both the total radiant energy by means of silicon photodiodes calibrated against a cryogenic radiometer and the fraction of radiant energy that is deposited in dry air by means of a free air ionization chamber. The measured ionization charge was converted into energy absorbed in air by calculated effective W values of photons as a function of their energy based on new measurements of the W values in dry air for electron kinetic energies between 1 keV and 7 keV, also presented in this work. The measured absorption coefficients were compared with state-of-the art calculations and found to agree within 0.7% with data calculated earlier by Hubbell at energies above 4 keV but were found to differ by values up to 2.1% at 10 keV from more recent calculations of Seltzer.

The effect of the beta-emitting yttrium-90 citrate on the dose-response of dicentric chromosomes in human lymphocytes: a basis for biological dosimetry after radiosynoviorthesis.

The production of dicentric chromosomes in human lymphocytes by beta-particles of yttrium-90 (Y-90) was studied in vitro to provide a basis of biological dosimetry after radiosynoviorthesis (RSO) of persistent synovitis by intra-articular administration of yttrium-90 citrate colloid. Since the injected colloid may leak into the lymphatic drainage exposing other parts of the body to radiation, the measurement of biological damage induced by beta-particles of Y-90 is important for the assessment of radiation risk to the patients. A linear dose-response relationship (alpha = 0.0229 +/- 0.0028 dicentric chromosomes per cell per gray) was found over the dose range of 0.2176-2.176 Gy. The absorbed doses were calculated for exposure of blood samples to Y-90 activities from 40 to 400 kBq using both Monte Carlo simulation and an analytical model. The maximum low-dose RBE, the RBE(M) which is equivalent to the ratio of the alpha coefficients of the dose-response curves, is well in line with published results obtained earlier for irradiation of blood of the same donor with heavily filtered 220 kV X-rays (3.35 mm copper), but half of the RBE(M) relative to weakly filtered 220 kV X-rays. Therefore, it can be concluded that for estimating an absorbed dose during RSO by the technique of biological dosimetry, in vitro and in vivo data for the same radiation quality are necessary.

Experimental determination of practical peak voltage.

In diagnostic radiology the practical peak voltage was initially derived by postulating that, for a given combination of X-ray tube and contrast geometry, a constant X-ray tube voltage should produce the same low level contrast as an arbitrarily pulsating X-ray tube voltage. It has been shown previously that the practical peak voltage can be properly defined as a weighted average of the X-ray tube voltage. Up to now the concept of practical peak voltage was based entirely on the results of calculations. The present paper describes the experimental investigations for measuring and comparing the contrast-equivalent X-ray tube voltage and practical peak voltage derived from an invasive measurement of the time-dependent X-ray tube voltage. Within the experimental uncertainties, the results demonstrate the mutual equivalence of the practical peak voltage and the contrast-equivalent X-ray tube voltage.

The practical peak voltage of diagnostic X-ray generators.

A new quantity termed the "practical peak voltage" is proposed. This quantity is derived by equating the low level contrast in an exposure made with an X-ray tube connected to a generator delivering any arbitrary wave form, to the contrast produced by the same X-ray tube connected to a constant potential generator. Out of the great number of possible contrast configurations one is selected as being suitable for diagnostic radiology. By means of an eigenvalue problem a direct link is established between the electrical quantity X-ray tube voltage and the practical peak voltage which was initially defined through the properties of the X-ray field. It is shown that the spread in total X-ray tube filtration as encountered in medical diagnostic radiology can influence the result of a measurement of the practical peak voltage only marginally.