Evaluation of the Protective Effect of Ademetionine, Cytoflavin, and Dihydroquercetetine on Blood Enzymes Activity in Rats Treated with High Doses of Sodium Valproate.

We evaluated the protective effect of ademetionine, cytoflavin, and dihydroquercetin on activity of serum enzymes in rats treated with high doses of sodium valproate for 28 days. Ademetionine and cytoflavin produced the greatest protective effect, the effect of dihydroquercetin was less pronounced. In rats treated with ademetionine, AST activity decreased as soon as on day 7 and remained at this level until the end of the experiment; ALT, alkaline phosphatase, and γ-glutamyl transferase activities decreased on days 21 and 28 of the study. Cytoflavin produced similar effects, the effect of dihydroquercetin was observed on days 21 and 28 for AST, ALT, alkaline phosphatase and on day 28 for γ-glutamyl transferase. These results substantiate the use of hepatoprotective drugs in case of long-term treatment with anticonvulsants in patients with epilepsy.

[The limitation of lipid hyperperoxidation and the prevention of stressor damages to the heart by glycine derivatives]. / Ogranichenie giperperoksidatsii lipidov i preduprezhdenie stressornykh povrezhdenii serdtsa proizvodnymi glitsina.

It is shown that glycine derivatives decrease considerably activation of lipid peroxidation in stress, reduce the duration of the alarm stage of the stress reaction, and limit the stress damage to the heart. The idea of the organism's glycinergic stress limiting system is suggested.

[Neurosonography after operations for syringomyelia and the Arnold-Chiari malformation type 1]. / Neirosonografiia posle operatsii po povodu siringomielii i mal'formatsii Arnol'da--Kiari tipa 1.

The paper provides the authors' experience in using neurosonography in the diagnosis of osteoneural abnormalities of the vertebral canal and craniovertebral passage in 22 patients operated on for syringomyelia and Type 1 Arnold-Chiari malformation. Comparison of computed tomographic and X-ray findings and intraoperative verification indicate that neurosonography is of high informative value and they provide evidence for its use in a diagnostic set of follow-ups of patients operated on.

[The transplantation of embryonic nerve tissue in syringomyelia: initial clinical experience]. / Transplantatsiia émbrional'noi nervnoi tkani pri siringomielii: pervyi klinicheskii opyt.

The paper gives clinical findings of 5 cases of syringomyelia surgical treatment using neurotransplantation of embryonal spinal marrow nerve tissue into the intramedullary cavity. It also discusses problems of sampling, culture and transplantation of embryonal spinal marrow nerve tissues, as well as the results and prospects of this method application.