Could real-time sonoelastography-measured placental strain ratio (PSR) value be a soft marker for the diagnosis of intrahepatic cholestasis of pregnancy?: A case-control study and short reviews.

Diagnosis of intrahepatic cholestasis of pregnancy (ICP) is often decided upon with typical pruritus supported by elevated serum bile acid levels. However, there is confusion regarding the absolute reference range for serum bile acid . To confirm the utility of Placental Strain Ratio (PSR) measurement as a marker for the diagnosis of ICP and to reveal the extent to which it is correlated with serum bile acid concentration. A case-control study was conducted. The case group included 29 patients who were admitted to our hospital in the second or third trimester of pregnancy with typical itching and were clinically diagnosed with ICP with >10 mmol/L serum bile acid. The first 45 pregnant women were assigned to a control group. Real-time tissue elastography software was used for ultrasound assessment of all pregnant placentas. Software was used to estimate the SR values. Biochemical liver function parameters, hemograms, serum bile acid levels, and SR values were compared between these groups. PSR was found to predict the development of cholestasis with poor discrimination (area under the curve [AUC] = 0.524; 95% CI = 0.399-0.646). The optimal threshold value with the best sensitivity and specificity rates was calculated to be 0.46 PSR. ICP developed significantly more frequently in the low PSR group than in the high PSR group (60% vs 29.3%, P  = .05, odds ratios [OR] = 0.276, 95% CI = 0.069-1.105). No correlation was found between the PSR and bile acid levels (rho = -0.029, P  = .816). PSR values can support the diagnosis of ICP, predict serum bile acid levels, and can be used as soft markers.

A new conservative treatment approach to vesicovaginal fistula cases: a case report and mini-review of the literature.

EINLEITUNG: Eine vesikovaginale Fistel (VVF) ist ein anormaler Weg zwischen der Blase und der Vagina, der es ermöglicht, dass Urin kontinuierlich unbeabsichtigt in die Vagina abfließt. Die Operation ist die am häufigsten bevorzugte Methode zur Behandlung von Frauen, jedoch wird die chirurgische Option für einige Patienten aufgrund der Patientennachfrage und der Kostenanalyse nicht gewählt. Außerdem kann nach einer chirurgischen VVF-Reparatur eine Restharninkontinenz beobachtet werden. In diesem Zustand werden konservative Behandlungsmethoden versucht. Der Erfolg dieser Methoden bleibt jedoch begrenzt. In diesem Sinne ist die Notwendigkeit für ein neues Behandlungsmodell entstanden. FALLBERICHT: Wir haben einen neuen Ansatz getestet, einschließlich der Injektion von plättchenreichem Plasma in den Fistelgang, und es hat eine kürzere Erholungszeit von 10 Tagen bewirkt, wenn nur die Katheterisierung und die anticholinerge Anwendung berücksichtigt wurden. SCHLUSSFOLGERUNG: Plättchenreiches Plasma kann vesikovaginale Fisteln behandeln, es hätte die Schließzeit verkürzen können und die Erfolgsrate der Operation erhöhen können, wenn es vor der Operation angewendet wird.

Review spontaneous superior mesenteric artery aneurysm rupture following caesarean section: an uncommon event and review of current literature.

Pregnancy-related rupture of an arterial aneurysm is an unusual occurrence associated with an increased risk of morbidity and mortality. Splenic artery aneurysms are the most common (60%), followed by hepatic (20%), superior mesenteric (5.9%), coeliac (4%), ovarian, uterine, and renal (<2%) arteries during pregnancy. Rupture of the superior mesenteric artery is uncommon. We present a case of a maternal death occurring after spontaneous rupture of a superior mesenteric artery after caesarean section. On the third day of post-operation, the woman presented with sudden onset of abdominal pain and collapse. At laparotomy she was found to have massive intraperitoneal bleeding because of superior mesenteric artery rupture.We report this case to increase awareness of superior mesenteric artery rupture during pregnancy, even during the postpartum period in patients presenting to the emergency service with haemorrhagic shock.

Ineffectual Medical Treatment of Cesarean Scar Ectopic Pregnancy With Systemic Methotrexate: A Report of Two Cases.

The implantation of a pregnancy within the scar of a previous cesarean section is known as a "cesarean scar pregnancy." Its incidence was reported to be 6.1%. However, with the increasing rates of cesarean sections, the incidence is expected to rise. A variety of conservative and surgical treatment modalities have been proposed for the management of cesarean scar pregnancy; however, there are no optimal universal treatment guidelines because of its rarity. Treatment should be tailored to the individual patient. It is obvious that more scar pregnancies will be seen in the future and therefore a set of criteria for the choice of various modes of management should be developed. Here, we present 2 cases of cesarean scar pregnancies treated with a local injection of potassium chloride after the failure of methotrexate administration.

An interesting prenatal diagnosis: double aneuploidy.

Double aneuploidy, the existence of two chromosomal abnormalities in the same individual, is a rare condition. Early diagnosis of this condition is important to offer termination of pregnancy in genetic counselling. Cytogenetic analysis with amniocentesis and ultrasound examination is valuable for diagnosis of double aneuploidy. In this report we present a case with the karyotype of 48XXY+21 diagnosed prenatally.

A giant cystic leiomyoma mimicking an ovarian malignancy.

INTRODUCTION: Leiomyoma of the uterus is the most common type of tumor affecting the female pelvis and arises from uterine smooth muscle. The size of leiomyomas varies from microscopic to giant; giant myomas are exceedingly rare. We report an unusual case of a large, cystic, pedunculated uterine leiomyoma mimicking a primary malignant ovarian tumor on sonography and CT. PRESENTATION OF CASE: A 58-year-old postmenopausal nulliparous woman presented with a history of lower abdominal pain and distension for a period of approximately 12 months. The patient's personal history revealed difficulty in walking, tiredness and recent weight gain of approximately 25kg. Sonography and CT examination showed a large mass that filled the abdomen. A preoperative diagnosis of a primary malignant ovarian tumor was made. The patient underwent laparotomy, total hysterectomy and bilateral salpingo-ooferectomy. The histology revealed a leiomyoma with extensive cystic degeneration. DISCUSSION: The current established management of uterine fibroids may involve expectant, surgical, or medical management or uterine artery embolization or a combination of these treatments. A surgical approach is preferred for management of giant leiomyomas. CONCLUSION: Pedunculated leiomyomas should be considered in the differential diagnosis of a multilocular and predominantly cystic adnexal mass.