RESUMEN
Schiff bases are compounds that have gained importance in the paint industry due to their colorful nature and in the field of chemistry and biochemistry due to their biological activities. Various biological applications of Schiff bases, such as antitumor, antifungal, antibacterial, antioxidant, antituberculosis, and anthelmintic, have been widely studied. Within the scope of the study, 5-bromo-2-hydroxybenzaldehyde and amino acid methyl esters (isoleucine, phenylalanine, and methionine) and amino acid Schiff bases were synthesized first. The synthesis of the new Zn(II) complexes of these Schiff bases was carried out by the reaction of synthesized Schiff bases and Zn(OAc)2 ·2H2 O. The structures of the synthesized complexes were elucidated using elemental analysis, Fourier transform infrared, nuclear magnetic resonance, UV-visible, and thermal analysis spectroscopy techniques. These synthesized salts were found to be effective inhibitor compounds for the α-glycosidase, and acetylcholinesterase enzyme with Ki values in the range of 30.50 ± 3.82-38.17 ± 6.26 µM for α-glycosidase, 3.68 ± 0.54-10.27 ± 1.68 µM for butyrylcholinesterase, and 6.26 ± 0.83-15.73 ± 4.73 µM for acetylcholinesterase, respectively.
Asunto(s)
Acetilcolinesterasa , Enfermedad de Alzheimer/tratamiento farmacológico , Butirilcolinesterasa/química , Inhibidores de la Colinesterasa , Complejos de Coordinación , Simulación del Acoplamiento Molecular , Zinc , Acetilcolinesterasa/química , Inhibidores de la Colinesterasa/síntesis química , Inhibidores de la Colinesterasa/química , Inhibidores de la Colinesterasa/uso terapéutico , Complejos de Coordinación/síntesis química , Complejos de Coordinación/química , Complejos de Coordinación/uso terapéutico , Proteínas Ligadas a GPI/antagonistas & inhibidores , Proteínas Ligadas a GPI/química , Humanos , Bases de Schiff/síntesis química , Bases de Schiff/química , Bases de Schiff/uso terapéutico , Zinc/química , Zinc/uso terapéuticoRESUMEN
The mol-ecule of the title compound, C(12)H(12)S(2), is close to planar, with the methyl C atoms deviating by 0.019â (1) and 0.221â (2)â Å from the naphthalene mean plane. In the crystal structure, the shortest Sâ¯S contact of 3.6864â (9)â Å is longer than the van der Waals contact distance.