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1.
Opt Express ; 32(9): 16248-16259, 2024 Apr 22.
Artículo en Inglés | MEDLINE | ID: mdl-38859257

RESUMEN

We introduce a novel approach in optical engineering by combining Dammann gratings with binary Fresnel zone plates to create a unique hybrid optical element with enhanced energetic efficiency of its focal spots. Traditionally, binary Fresnel zone plates focus light at multiple points with varying intensities, while Dammann gratings are renowned for their efficient and uniform light splitting capabilities. Our innovation lies in merging these two elements and generating a binary circular Dammann (varying along the radial direction) Fresnel zone plate that concentrates most of the incident light into a small and desired number of focused points with equal intensities, rather than distributing light's energy non-equally across multiple points. This novel design significantly enhances the efficiency and precision of light manipulation. It opens new possibilities in applications requiring high-intensity focal points, such as in advanced medical imaging and in accurate scientific measurements. By redefining the conventional roles of these optical elements, our research contributes an advancement to the field, paving the way for innovative solutions in various optical applications.

2.
ACS Omega ; 9(15): 16969-16975, 2024 Apr 16.
Artículo en Inglés | MEDLINE | ID: mdl-38645321

RESUMEN

In this research, we present a novel approach to achieving super-resolution in silicon using the plasma dispersion effect (PDE) that temporarily controls the complex refractive index of matter. By employing a laser vortex pump beam, which is absorbed in the silicon, we can shape the complex refractive index as a gradient index (GRIN) lens, enabling the focusing of a laser probe beam within the material. Our study introduces a single beam at a wavelength of 775 nm for both the pump and the probe beams, offering tunable focusing capabilities and the potential to attain higher spatial resolution. These findings hold significant promise for applications in nanoelectronics and integrated circuit failure analysis, paving the way for advanced semiconductor imaging and analysis techniques.

3.
Sci Rep ; 13(1): 18081, 2023 Oct 23.
Artículo en Inglés | MEDLINE | ID: mdl-37872441

RESUMEN

This paper presents an approach for achieving full optical photoacoustic imaging with enhanced resolution utilizing speckle pattern analysis. The proposed technique involves projecting patterns derived from binary masks corresponding to orthogonal functions onto the target to elicit a photoacoustic signal. The resulting signal is then recorded using a high-speed camera and analyzed using correlation analysis of the speckle motion. Our results demonstrate the feasibility of this optical approach to achieve imaging with enhanced resolution without the need for physical contact with the target, opening up new possibilities for non-invasive medical imaging and other applications.

4.
Sci Rep ; 12(1): 16614, 2022 10 05.
Artículo en Inglés | MEDLINE | ID: mdl-36198733

RESUMEN

Cilia motion is an indicator of pathological-ciliary function, however current diagnosis relies on biopsies. In this paper, we propose an innovative approach for sensing cilia motility. We present an endoscopic configuration for measuring the motion frequency of cilia in the nasal cavity. The technique is based on temporal tracking of the reflected spatial distribution of defocused speckle patterns while illuminating the cilia with a laser. The setup splits the optical signal into two channels; One imaging channel is for the visualization of the physician and another is, defocusing channel, to capture the speckles. We present in-vivo measurements from healthy subjects undergoing endoscopic examination. We found an average motion frequency of around 7.3 Hz and 9.8 Hz in the antero-posterior nasal mucus (an area rich in cilia), which matches the normal cilia range of 7-16 Hz. Quantitative and precise measurements of cilia vibration will optimize the diagnosis and treatment of pathological-ciliary function. This method is simple, minimally invasive, inexpensive, and promising to distinguish between normal and ciliary dysfunction.


Asunto(s)
Cilios , Sistema Respiratorio , Biopsia , Cilios/patología , Humanos , Movimiento (Física) , Moco , Mucosa Nasal
5.
Sci Rep ; 12(1): 6342, 2022 Apr 15.
Artículo en Inglés | MEDLINE | ID: mdl-35428805

RESUMEN

We report here on focusing of a probe IR (λ = 1.55 µm) laser beam in silicon. The focusing is done by a second pump laser beam, at λ = 0.775 µm and 30 ps pulse width, with a donut shape that is launched collinearly and simultaneously (with some delay time) with the IR beam pulse. The pump beam pulse is absorbed in the silicon and creates, temporally, a free charge carriers (FCCs) donut pattern in the silicon. Following the plasma dispersion effect, the donut FCCs shapes a complex index of refraction pattern in the silicon that serves as a sort of dynamic GRIN lens for the probe beam due to the diffusion of the FCCs towards the donut center. This lens can be tuned to its focal point by the pump-probe delay time to reduce the point spread function (PSF) of the IR probe beam. We start seeing the focusing of the probe beam at pump-probe delay time of [Formula: see text]. The best focusing (results in PSF [Formula: see text]) was observed at [Formula: see text] and it slowly degrades before the FCCs full recombination at [Formula: see text]. We propose this beam shaping method to overcome the diffraction resolution limit in silicon microscopy on and deep under the silicon surface dependent on the pump wavelength and the pulse width. We also proposed this technique for direct measurement of the FCCs dynamics.

6.
Sci Rep ; 10(1): 16619, 2020 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-32999382

RESUMEN

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

7.
Opt Express ; 28(14): 20040-20050, 2020 Jul 06.
Artículo en Inglés | MEDLINE | ID: mdl-32680074

RESUMEN

Vocal folds lesions are commonly diagnosed using an endoscopic-stroboscope. However, the stroboscopic picture of the vocal folds vibrations is subjectively and qualitatively evaluated by the clinician and, due to technical limitations, is unable to accurately distinguish between healthy and pathologic regions. In this paper, we propose two optical approaches for objectively sensing the vocal folds vibrations, using either external or internal laser illumination, based on temporal tracking of the reflected spatial distribution of secondary speckle patterns. The external configuration (the neck) is noninvasive and the internal configuration (the larynx) allows simultaneous extraction of data from multiple sites on the vocal folds. In this paper, we present measurements of healthy human subjects. Quantitative and precise measurements of vibration parameters of the vocal folds will enable a better understanding of hidden pathologies and optimize the diagnosis and treatment.


Asunto(s)
Algoritmos , Fenómenos Ópticos , Vibración , Pliegues Vocales/fisiología , Humanos , Procesamiento de Imagen Asistido por Computador , Rayos Láser
8.
Sci Rep ; 10(1): 9142, 2020 06 04.
Artículo en Inglés | MEDLINE | ID: mdl-32499607

RESUMEN

Photoacoustic endoscopy (PAE) is a method of in-vivo imaging that uses tissue absorption properties. In PAE, the main tools used to detect the acoustic signal are mechanical ultrasound transducers, which require direct contact and which are difficult to miniaturize. All-optic photoacoustic sensors can challenge this issue as they can provide contact-free sensing. Here, we demonstrate sensing of photo-acoustic signals through a multimode fiber (MMF) which can provide an ultra-thin endoscopic photoacoustic sensor. Furthermore, we show the advantage of using the optical-flow method for speckle sensing and extract the photoacoustic signal despite the mode-mixing along the MMF. Moreover, it is demonstrated for the first time that the speckle reconstruction method can be used without the need for imaging of the speckles as this enables the use of multimode fibers for the speckle method.

9.
Sci Rep ; 10(1): 6029, 2020 Apr 02.
Artículo en Inglés | MEDLINE | ID: mdl-32238830

RESUMEN

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

10.
Sci Rep ; 10(1): 4755, 2020 Mar 16.
Artículo en Inglés | MEDLINE | ID: mdl-32179817

RESUMEN

Superoscillation is a technique that is used to produce a spot of light (known as 'hotspot') which is smaller than the conventional diffraction limit of a lens and even smaller than the optical wavelength. Over the past few years, several techniques have been realized for the generation of the superoscillatory hotspot. In this article, for the first time to the best of our knowledge, we propose a novel and a more efficient technique for producing superoscillation in microscopic imaging by shaping the Coherent Transfer Function (CTF) of a lens via virtual Fourier filtering followed by a phase retrieval algorithm. We design and realize a phase mask which when placed at the pupil plane of a diffraction-limited lens produces a superoscillatory hotspot with sidelobes properly matched to the field of view (FOV) required in microscopic imaging applications, i.e. hotspot always coexists with huge intense rings known as 'sidebands' close to it and hence limiting the FOV. Our technique is also capable of extending the FOV with minimal loss in resolution of the hotspot generated and considerable ratio between the intensity of the hotspot to that of the side lobes while optimizing the obtainable FOV to the requirement of microscopy.

11.
Biomed Opt Express ; 10(9): 4874-4883, 2019 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-31565531

RESUMEN

An optical approach to determine the hydration level in human skin is presented. The approach is based on temporal tracking of back-reflected secondary speckle patterns generated while illuminating the tested area with a laser and applying periodic vibrations to the surface via a controlled vibration source (CVS). This approach has already been tested successfully for other biomedical parameters such as sensing vital signs, hematology and hemodynamic processes in the body. In this paper we examine and adjust this optical technique with the aim of measuring human skin moisture. We compare the suitability and accuracy of our optical method to the commercially available device for skin moisture measurements, the Corneometer CM 825 (by Courage + Khazaka, Cologne, Germany). Preliminary experiments showing the method's suitability for hydration measurements are presented, may lead to more accurate results that may upgrade the control of the cosmetic industry as well as identifying symptoms of moisture-related skin diseases.

12.
Sci Rep ; 9(1): 12275, 2019 08 22.
Artículo en Inglés | MEDLINE | ID: mdl-31439914

RESUMEN

Fundamental challenge of imaging through a scattering media has been resolved by various approaches in the past two decades. Optical wavefront shaping technique is one such method in which one shapes the wavefront of light entering a scattering media using a wavefront shaper such that it cancels the scattering effect. It has been the most effective technique in focusing light inside a scattering media. Unfortunately, most of these techniques require direct access to the scattering medium or need to know the scattering properties of the medium beforehand. Through the novel scheme presented on this paper, both the illumination module and the detection are on the same side of the inspected object and the imaging process is a real time fast converging operation. We model the scattering medium being a biological tissue as a matrix having mathematical properties matched to the physical and biological aspects of the sample. In our adaptive optics scheme, we aim to estimate the scattering function and thus to encode the intensity of the illuminating laser light source using DMD (Digital Micromirror Device) with an inverse scattering function of the scattering medium, such that after passing its scattering function a focused beam is obtained. We optimize the pattern to be displayed on the DMD using Particle Swarm Algorithm (PSO) which eventually help in retrieving a 1D object hidden behind the media.

13.
Opt Lett ; 43(22): 5603-5606, 2018 Nov 15.
Artículo en Inglés | MEDLINE | ID: mdl-30439920

RESUMEN

The rapid growth of applications that rely on artificial neural network (ANN) concepts gives rise to a staggering increase in the demand for hardware implementations of neural networks. New types of hardware that can support the requirements of high-speed associative computing while maintaining low power consumption are sought, and optical artificial neural networks fit the task well. Inherently, optical artificial neural networks can be faster, support larger bandwidth, and produce less heat than their electronic counterparts. Here we propose the design of an optical ANN-based imaging system that has the ability to self-study image signals from an incoherent light source in different colors. Our design consists of a combination of a multimode fiber and a multi-core optical fiber realizing a neural network. We show that the signals, transmitted through the multimode fiber, can be used for image identification purposes and can also be reconstructed using ANNs with a low number of nodes. An all-optical solution can then be achieved by realizing these networks with the multi-core optical neural network fiber.

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