Highlights from ASCO 2020: updates on the treatment of chronic lymphocytic leukemia.

Because of the global coronavirus pandemic, the 2020 annual scientific meeting of the American Society of Clinical Oncology took place virtually, 29-30 May. At the meeting, results from key studies about the treatment of chronic lymphocytic leukemia (cll) were disseminated. Studies examined the efficacy and safety of ibrutinib, acalabrutinib, zanubrutinib, and venetoclax as monotherapy or in combination with novel agents for patients with treatment-naïve and relapsed or refractory cll. Our meeting report describes the foregoing studies and presents interviews with investigators and commentaries by Canadian hematologists about potential effects on Canadian practice.

Corrigendum to "Predicting entropy generation in flow of non-Newtonian flow due to a stretching sheet with chemically reactive species" [Comput. Methods Prog. Biol. 187 (2020) 105246].

This is the corrigendum to our recent published research article [1] in which the analysis of non-Newtonian fluid (Williamson model) is presented in the presence of entropy generation by a stretched surface. Total entropy rate is discussed via thermodynamics second law. The results are arranged for nonlinear ODE's through Rung Kutta integration technique with shooting method. In this communication [1] some minor typing errors are noted which is occurred during the writing and typing of momentum, energy and entropy generation. Therefore, we have rewritten the above mentioned equations in correct form in this corrigendum. Note that the updated version of manuscript does not affect the scientific and physical validity of the paper.

Predicting entropy generation in flow of non-Newtonian flow due to a stretching sheet with chemically reactive species.

BACKGROUND: We have studied the steady Darcy Forchheimer MHD generalized non-Newtonian flow of an incompressible non-linear stretched surface in the presence chemical reactive species. Darcy Forchheimer effect and chemically reactive species are considered under entropy generation. Entropy generation analysis has been essentially applied in engineering procedure in order to improve the theoretical and mathematical evaluation problems. METHOD: To approximate the entropy generation rate, the leading nonlinear equations are solved numerically by using Rung Kutta integration technique with shooting method. RESULTS: Next using the reproduction date, the entropy generation results are discussed by using theoretical and mathematical approaches. The numerical results acquired for different physical mechanism are exposing through graphs and tables. CONCLUSIONS: The physical effects of nanomaterials, skin friction coefficient, heat transfer, mass transfer and entropy generation have been illustrated for different values of involved parameters such as the Weissenberg number, magnetic field parameter, porous medium parameter, the Darcy parameter, the Lewis number, thermophoresis diffusion, the Brownian motion parameter, chemical reaction parameter and the Prandtl number. The numerical results acquired for different physical mechanism are exposing through graphs and tables.

Preferences of patients and physicians concerning treatment options for relapsed follicular lymphoma: a discrete choice experiment.

The purpose of this study was to elicit relative preferences for common treatment options of relapsed follicular lymphoma, and their associated attributes, amongst lymphoma patients in Alberta, and lymphoma-treating physicians in Canada, using a discrete choice experiment (DCE). Treatment administration, toxicity, survival free of relapse and cost were the attributes evaluated for four treatment options: standard chemotherapy (CT), radioimmunotherapy (RIT), high-dose CT and auto-SCT, and allo-SCT. For the 81 patients and 48 physicians who participated in this study, survival free of relapse was a positive influence on choice (P<0.001), whereas negative influences on choice included toxicity of allo-SCT (P<0.001 for patients, P=0.005 for physicians) and cost (P=0.001 for physicians only). The estimated uptake of the treatment options for patients was as follows: auto-SCT (69%), RIT (14%), CT (11%) and allo-SCT (7%). The distribution for physicians was similar (56, 20, 19 and 4%, respectively). In conclusion, patients with relapsed follicular lymphoma are able to consider the different attributes of various treatment options and are willing to trade off the need for hospitalization, associated toxicity and cost associated with autologous transplantation in order to benefit from an increased PFS.