Aroma compounds identified in cooked meat: A review.

Early reviews focused on volatile compounds in cooked meat or meat products by GC-MS analysis. However, actually only a small number of odor-active activities, i.e., odorants, play roles in meat aroma. This review summarized in total 332 odorants identified in thermally cooked meat species (e.g., stewed pork) in the recent 40 years by GC-O through the search of relevant literatures. They included l57 compounds from the lipid degradation, 98 compounds from the Maillard reaction, 18 compounds from the interaction of the lipid degradation and the Maillard reaction (lipid-Maillard interaction), and 59 compounds from other sources, while the formation mechanisms are discussed based on the recent developments. Overall, the aliphatic aldehydes had the greatest number, followed by sulfur-containing compounds, nitrogen-containing heterocyclic compounds, oxygen-containing heterocyclic compounds, ketones, alcohols, etc. The frequently potent odorants in different cooked meat species are the short-chain aliphatic aldehydes of C6-C10 carbons and 1-oceten-3-ol (or 1-octen-3-one) and sulfur-containing or nitrogen-containing heterocyclic compounds. PLS-DA analysis suggested variation of odorants among the cooked beef, pork, poultry, and sheep was more due to the lipid degradation than the Maillard reaction, and marginally due to the lipid-Maillard interaction. This review can be used as guidance in improving flavor of cooked meat and meat flavorings.

Exploring bioactive peptides as potential therapeutic and biotechnology treasures: A contemporary perspective.

In preceding years, bioactive peptides (BAPs) have piqued escalating attention owing to their multitudinous biological features. To date, many potential BAPs exhibiting anti-cancer activities have been documented; yet, obstacles such as their safety profiles and consumer acceptance continue to exist. Moreover, BAPs have been discovered to facilitate the suppression of Coronavirus Disease 2019 (CoVID-19) and maybe ideal for treating the CoVID-19 infection, as stated by published experimental findings, but their widespread knowledge is scarce. Likewise, there is a cornucopia of BAPs possessing neuroprotective effects that mend neurodegenerative diseases (NDs) by regulating gut microbiota, but they remain a subject of research interest. Additionally, a plethora of researchers have attempted next-generation approaches based on BAPs, but they need scientific attention. The text format of this critical review is organized around an overview of BAPs' versatility and diverse bio functionalities with emphasis on recent developments and novelties. The review is alienated into independent sections, which are related to either BAPs based disease management strategies or next-generation BAPs based approaches. BAPs based anti-cancer, anti-CoVID-19, and neuroprotective strategies have been explored, which may offer insights that could help the researchers and industries to find an alternate regimen against the three aforementioned fatal diseases. To the best of our knowledge, this is the first review that has systematically discussed the next-generation approaches in BAP research. Furthermore, it can be concluded that the BAPs may be optimal for the management of cancer, CoVID-19, and NDs; nevertheless, experimental and preclinical studies are crucial to validate their therapeutic benefits.

Disseminated Lomentospora prolificans infection presenting with arterial exsanguination.

Lomentospora prolificans is an opportunistic fungal pathogen found especially in Australia, Spain, Portugal, California, and the southern United States. Although it causes a wide spectrum of infections, disseminated L. prolificans infection remains very rare. The diagnosis and medical management are challenging. No clear guidelines are available for management. The treatment options are limited and mortality is high, especially for immunocompromised patients. In the present case report, we have highlighted the rare vascular effect of disseminated L. prolificans infection. We have reported the case of a 48-year-old immunocompromised man who had presented with a right groin mass. After extensive workup, the patient was found to have disseminated L. prolificans infection causing a superficial femoral artery pseudoaneurysm. A multidisciplinary team was involved to provide medical and surgical care. However, the patient died after treatment failure and withdrawal of support.

Cholesterol levels in fragile X syndrome.

Fragile X syndrome (FXS) is associated with intellectual disability and behavioral dysfunction, including anxiety, ADHD symptoms, and autistic features. Although individuals with FXS are largely considered healthy and lifespan is not thought to be reduced, very little is known about the long-term medical health of adults with FXS and no systematically collected information is available on standard laboratory measures from metabolic screens. During the course of follow up of a large cohort of patients with FXS we noted that many patients had low cholesterol and high density lipoprotein (HDL) values and thus initiated a systematic chart review of all cholesterol values present in charts from a clinic cohort of over 500 patients with FXS. Total cholesterol (TC), low density lipoprotein (LDL) and HDL were all significantly reduced in males from the FXS cohort relative to age-adjusted population normative data. This finding has relevance for health monitoring in individuals with FXS, for treatments with cholesterol-lowering agents that have been proposed to target the underlying CNS disorder in FXS based on work in animal models, and for potential biomarker development in FXS.