RESUMEN
Anticoagulants are the first-line treatment option for patients with Budd-Chiari syndrome (BCS); however, intervention is required when this fails. Although, the ultimate treatment is liver transplant, other radiological procedures are for the management of the disease and bridge to definitive therapy. TIPS (trans jugular intrahepatic portosystemic shunt) is a method used by interventional radiologists to create a shunt between portal vein and hepatic vein. At times it is technically not possible, in such cases, direct intrahepatic portosystemic shunt (DIPS) is performed. This patient underwent a successful DIPS procedure for BCS along with balloon dilatation (venoplasty) for inferior vena cava (IVC) stenosis.
Asunto(s)
Síndrome de Budd-Chiari , Derivación Portosistémica Intrahepática Transyugular , Humanos , Derivación Portosistémica Intrahepática Transyugular/métodos , Países en Desarrollo , Venas Hepáticas/diagnóstico por imagen , Venas Hepáticas/cirugía , Síndrome de Budd-Chiari/cirugía , Resultado del Tratamiento , Vena Cava Inferior/diagnóstico por imagen , Vena Cava Inferior/cirugíaRESUMEN
Vascular thrombosis is an unusual yet well-known extra-intestinal complication of ulcerative colitis, usually involving the peripheral veins and occasionally the cerebral veins and the arterial system. We, herein, report a case of a 45-year female with ulcerative colitis in remitting phase presenting with anemia and right lower limb swelling and discoloration due to extensive arterial and venous thrombosis. Early and accurate diagnosis of thrombotic complications is essential to start limb-saving and life-saving therapy. Key Words: Thrombotic, Ulcerative colitis.
Asunto(s)
Venas Cerebrales , Colitis Ulcerosa , Trombosis , Trombosis de la Vena , Arterias , Colitis Ulcerosa/complicaciones , Colitis Ulcerosa/tratamiento farmacológico , Femenino , Humanos , Trombosis de la Vena/etiologíaRESUMEN
This paper focuses on the development of a drug delivery system for systemically controlled release of a poorly soluble drug, letrozole. The work meticulously describes the preparation and characterizations of 2-hydroxyethyl methacrylate (HEMA) polymerization onto hydrophilic acrylamide grafted low-density polyethylene (AAm-g-LDPE) surface for targeted drug release system. The surface morphology and thickness measurement of coated pHEMA layer were measured using scanning electron microscopy (SEM). The swelling study was done in deionized (DI) water and simulated uterine fluid (SUF, pH = 7.6). In vitro release of letrozole from the system was performed in SUF. Further, the release kinetics of letrozole from the system was studied using different mathematical models. The results, suggest that the rate of drug release can be altered by varying the concentrations of cross-linker in pHEMA. The optimized sample released 72% drug at the end of 72 h of measurement.