1.
Chem Commun (Camb)
; 58(81): 11438-11441, 2022 Oct 11.
Artículo
en Inglés
| MEDLINE
| ID: mdl-36135099
RESUMEN
We report a mitochondria-targeted nitroreductase (NTR)-activated near-infrared fluorescent probe: CS-NO2. Overexpressed NTR in mitochondria was measured with high sensitivity. More importantly, the probe CS-NO2 successfully monitored NTR activity in solid tumors and a hind-limb model of ischemia in mice. This novel finding indicates the promising function of our probe for the diagnosis of solid tumors and hypoxia-associated diseases.