Building the bioeconomy: A targeted assessment approach to identifying biobased technologies, challenges and opportunities.

The authors explore opportunities, challenges, and strategies to translate and responsibly scale innovative biobased technologies to build more sustainable bioeconomies. The pandemic and other recent disruptions increased exposure to issues of resilience and regional imbalance, highlighting a need for production and consumption regimes centred more on local biobased resources and dispersed production. The authors review potential biobased technology strategies and identify promising and feasible options for the United Kingdom. Initial landscape and bibliometric analysis identified 50 potential existing and emerging biobased technologies, which were assessed for their ability to fulfil requirements related to biobased production, national applicability, and economic-, societal-, and environmental-benefits, leading to identification of 18 promising biobased production technologies. Further analysis and focus-group discussion with industrial, governmental, academic, agricultural, and social stakeholders, identified three technology clusters for targeted assessment, drawing on cellulose-, lignin-, and seaweed feedstocks. Case studies were developed for each cluster, addressing conversations around sustainable management, use of biomass feedstocks, and associated environmental-, social-, and economic challenges. Cases are presented with discussion of insights and implications for policy. The approach presented is put forward as a scalable assessment method that can be useful in prompting, informing, and advancing discussion and deliberation on opportunities and challenges for biobased transformations.

Mapping technological innovation dynamics in artificial intelligence domains: Evidence from a global patent analysis.

Artificial intelligence (AI) is emerging as a technology at the center of many political, economic, and societal debates. This paper formulates a new AI patent search strategy and applies this to provide a landscape analysis of AI innovation dynamics and technology evolution. The paper uses patent analyses, network analyses, and source path link count algorithms to examine AI spatial and temporal trends, cooperation features, cross-organization knowledge flow and technological routes. Results indicate a growing yet concentrated, non-collaborative and multi-path development and protection profile for AI patenting, with cross-organization knowledge flows based mainly on interorganizational knowledge citation links.

Tracking developments in artificial intelligence research: constructing and applying a new search strategy.

Artificial intelligence, as an emerging and multidisciplinary domain of research and innovation, has attracted growing attention in recent years. Delineating the domain composition of artificial intelligence is central to profiling and tracking its development and trajectories. This paper puts forward a bibliometric definition for artificial intelligence which can be readily applied, including by researchers, managers, and policy analysts. Our approach starts with benchmark records of artificial intelligence captured by using a core keyword and specialized journal search. We then extract candidate terms from high frequency keywords of benchmark records, refine keywords and complement with the subject category "artificial intelligence". We assess our search approach by comparing it with other three recent search strategies of artificial intelligence, using a common source of articles from the Web of Science. Using this source, we then profile patterns of growth and international diffusion of scientific research in artificial intelligence in recent years, identify top research sponsors in funding artificial intelligence and demonstrate how diverse disciplines contribute to the multidisciplinary development of artificial intelligence. We conclude with implications for search strategy development and suggestions of lines for further research.

Bioengineering horizon scan 2020.

Horizon scanning is intended to identify the opportunities and threats associated with technological, regulatory and social change. In 2017 some of the present authors conducted a horizon scan for bioengineering (Wintle et al., 2017). Here we report the results of a new horizon scan that is based on inputs from a larger and more international group of 38 participants. The final list of 20 issues includes topics spanning from the political (the regulation of genomic data, increased philanthropic funding and malicious uses of neurochemicals) to the environmental (crops for changing climates and agricultural gene drives). The early identification of such issues is relevant to researchers, policy-makers and the wider public.

Rapid prototyping of microbial production strains for the biomanufacture of potential materials monomers.

Bio-based production of industrial chemicals using synthetic biology can provide alternative green routes from renewable resources, allowing for cleaner production processes. To efficiently produce chemicals on-demand through microbial strain engineering, biomanufacturing foundries have developed automated pipelines that are largely compound agnostic in their time to delivery. Here we benchmark the capabilities of a biomanufacturing pipeline to enable rapid prototyping of microbial cell factories for the production of chemically diverse industrially relevant material building blocks. Over 85 days the pipeline was able to produce 17 potential material monomers and key intermediates by combining 160 genetic parts into 115 unique biosynthetic pathways. To explore the scale-up potential of our prototype production strains, we optimized the enantioselective production of mandelic acid and hydroxymandelic acid, achieving gram-scale production in fed-batch fermenters. The high success rate in the rapid design and prototyping of microbially-produced material building blocks reveals the potential role of biofoundries in leading the transition to sustainable materials production.

Private and public values of innovation: A patent analysis of synthetic biology.

Emerging science and technology fields are increasingly expected to provide solutions to societal grand challenges. The promise of such solutions frequently underwrites claims for the public funding of research. In parallel, universities, public research organizations and, in particular, private enterprises draw on such research to actively secure property rights over potential applications through patenting. Patents represent a claim to garner financial returns from the novel outcomes of science and technology. This is justified by the potential social value promised by patents as they encourage information sharing, further R&D investment, and the useful application of new knowledge. Indeed, the value of patents has generated longstanding academic interest in innovation studies with many scholars investigating its determinants based on econometric models. Yet, this research has largely focused on evaluating factors that influence the market value of patents and the gains from exclusivity rights granted to inventions, which reflect the private value of a patent. However, the patent system is a socially shaped enterprise where private and public concerns intersect. Despite the notion of the social utility of inventions as a patenting condition, and evidence of disconnection between societal needs and the goals of private actors, less attention has been paid to other interpretations of patent value. This paper investigates the various articulations of value delineated by patents in an emerging science and technology domain. As a pilot study, we analyse patents in synthetic biology, contributing a new analytical framework and classification of private and public values at the intersections of science, economy, and society. After considering the legal, business, social and political dimensions of patenting, we undertake a qualitative and systematic examination of patent content in synthetic biology. Our analysis probes the private and public value propositions that are framed in these patents in terms of the potential private and public benefits of research and innovation. Based on this framework, we shed light on questions of what values are being nurtured in inventions in synthetic biology and discuss how attention to public as well as private values opens up promising avenues of research in science, technology and innovation policy.

Collaborating constructively for sustainable biotechnology.

Tackling the pressing sustainability needs of society will require the development and application of new technologies. Biotechnology, emboldened by recent advances in synthetic biology, offers to generate sustainable biologically-based routes to chemicals and materials as alternatives to fossil-derived incumbents. Yet, the sustainability potential of biotechnology is not without trade-offs. Here, we probe this capacity for sustainability for the case of bio-based nylon using both deliberative and analytical approaches within a framework of Constructive Sustainability Assessment. We highlight the potential for life cycle CO2 and N2O savings with bio-based processes, but report mixed results in other environmental and social impact categories. Importantly, we demonstrate how this knowledge can be generated collaboratively and constructively within companies at an early stage to anticipate consequences and to inform the modification of designs and applications. Application of the approach demonstrated here provides an avenue for technological actors to better understand and become responsive to the sustainability implications of their products, systems and actions.

Identifying author heritage using surname data: An application for Russian surnames.

This research article puts forward a method to identify the national heritage of authors based on the morphology of their surnames. Most studies in the field use variants of dictionary-based surname methods to identify ethnic communities, an approach that suffers from methodological limitations. Using the public file of ORCID (Open Researcher and Contributor ID) identifiers in 2015, we developed a surname-based identification method and applied it to infer Russian heritage from suffix-based morphological regularities. The method was developed conceptually and tested in an undersampled control set. Identification based on surname morphology was then complemented by using first-name data to eliminate false-positive results. The method achieved 98% precision and 94% recall rates-superior to most other methods that use name data. The procedure can be adapted to identify the heritage of a variety of national groups with morphologically regular naming traditions. We elaborate on how the method can be employed to overcome long-standing limitations of using name data in bibliometric datasets. This identification method can contribute to advancing research in scientific mobility and migration, patenting by certain groups, publishing and collaboration, transnational and scientific diaspora links, and the effects of diversity on the innovative performance of organizations, regions, and countries.

Anticipating governance challenges in synthetic biology: Insights from biosynthetic menthol.

This paper advances an anticipatory governance framework to investigate and prepare for the potential implications of an emerging technology. Within the growing domain of synthetic biology, we draw on an end-to-end assessment of biosynthetic menthol that incorporates consideration of multiple dimensions of production and use. Based on documentary analysis, available data, and interviews, our approach unfolds in three steps. First, we map the sociotechnical transition in menthol production, comparing existing agricultural and chemical production methods with new biosynthetic processes - or what we call the biological (bio) turn. Second, we explore the rationales, promises and expectations of menthol's bio-turn and explore the drivers of transition so as to clarify which goals and values innovation is addressing. Third, we reflect on the opportunities and challenges of such a transition to put forward an agenda for responsible innovation and anticipatory governance. The bio-turn in menthol is analysed through five responsible innovation dimensions: the potential distribution of benefits and burdens; social resilience; environmental sustainability; infrastructure and business models; and public perception and public interest. We consider the implications of our analysis both for the responsible development and application of synthetic biology for menthol and for the broader assessment and sociotechnical construction of emerging technologies.

Aligning sustainability assessment with responsible research and innovation: Towards a framework for Constructive Sustainability Assessment.

Emerging technologies are increasingly promoted on the promise of tackling the grand challenge of sustainability. A range of assessment and governance approaches seek to evaluate these claims, but these tend to be applied disparately and lack widespread operationalisation. They also face specific challenges, such as high levels of uncertainty, when it comes to emerging technologies. Building and reflecting on both theory and practice, this article develops a framework for Constructive Sustainability Assessment (CSA) that enables the application of sustainability assessments to emerging technologies as part of a broader deliberative approach. In order to achieve this, we discuss and critique current approaches to analytical sustainability assessment and review deliberative social science governance frameworks. We then develop the conceptual basis of CSA - blending life-cycle thinking with principles of responsible research and innovation. This results in four design principles - transdisciplinarity, opening-up, exploring uncertainty and anticipation - that can be followed when applying sustainability assessments to emerging technologies. Finally, we discuss the practical implementation of the framework through a three-step process to (a) formulate the sustainability assessment in collaboration with stakeholders, (b) evaluate potential sustainability implications using methods such as anticipatory life-cycle assessment and (c) interpret and explore the results as part of a deliberative process. Through this, CSA facilitates a much-needed transdisciplinary response to enable the governance of emerging technologies towards sustainability. The framework will be of interest to scientists, engineers, and policy-makers working with emerging technologies that have sustainability as an explicit or implicit motivator.

A transatlantic perspective on 20 emerging issues in biological engineering.

Advances in biological engineering are likely to have substantial impacts on global society. To explore these potential impacts we ran a horizon scanning exercise to capture a range of perspectives on the opportunities and risks presented by biological engineering. We first identified 70 potential issues, and then used an iterative process to prioritise 20 issues that we considered to be emerging, to have potential global impact, and to be relatively unknown outside the field of biological engineering. The issues identified may be of interest to researchers, businesses and policy makers in sectors such as health, energy, agriculture and the environment.

Tracking the emergence of synthetic biology.

Synthetic biology is an emerging domain that combines biological and engineering concepts and which has seen rapid growth in research, innovation, and policy interest in recent years. This paper contributes to efforts to delineate this emerging domain by presenting a newly constructed bibliometric definition of synthetic biology. Our approach is dimensioned from a core set of papers in synthetic biology, using procedures to obtain benchmark synthetic biology publication records, extract keywords from these benchmark records, and refine the keywords, supplemented with articles published in dedicated synthetic biology journals. We compare our search strategy with other recent bibliometric approaches to define synthetic biology, using a common source of publication data for the period from 2000 to 2015. The paper details the rapid growth and international spread of research in synthetic biology in recent years, demonstrates that diverse research disciplines are contributing to the multidisciplinary development of synthetic biology research, and visualizes this by profiling synthetic biology research on the map of science. We further show the roles of a relatively concentrated set of research sponsors in funding the growth and trajectories of synthetic biology. In addition to discussing these analyses, the paper notes limitations and suggests lines for further work.

Graphene enterprise: mapping innovation and business development in a strategic emerging technology.

This paper explores enterprise development and commercialization in the field of graphene. Firm characteristics and relationships, value chain positioning, and factors associated with product entry are examined for a set of 65 graphene-oriented small and medium-sized enterprises located in 16 different countries. As well as secondary sources and bibliometric methods to profile developments in graphene, we use computerized data mining and analytical techniques, including cluster and regression modeling, to identify patterns from publicly available online information on enterprise web sites. We identify groups of graphene small and medium-sized enterprises differentiated by how they are involved with graphene, the materials they target, whether they make equipment, and their orientation toward science and intellectual property. In general, access to finance and the firms' location are significant factors that are associated with graphene product introductions. We also find that patents and scientific publications are not statistically significant predictors of product development in our sample of graphene enterprises. We further identify a cohort of graphene-oriented firms that are signaling plans to develop intermediate graphene products that should have higher value in the marketplace. Our findings suggest that policy needs to ensure attention to the introduction and scale-up of downstream intermediate and final graphene products and associated financial, intermediary, and market identification support. The paper demonstrates novel data methods that can be combined with existing information for real-time intelligence to understand and map enterprise development and commercialization in a rapidly emerging and growing new technology.

Mapping the patent landscape of synthetic biology for fine chemical production pathways.

A goal of synthetic biology bio-foundries is to innovate through an iterative design/build/test/learn pipeline. In assessing the value of new chemical production routes, the intellectual property (IP) novelty of the pathway is important. Exploratory studies can be carried using knowledge of the patent/IP landscape for synthetic biology and metabolic engineering. In this paper, we perform an assessment of pathways as potential targets for chemical production across the full catalogue of reachable chemicals in the extended metabolic space of chassis organisms, as computed by the retrosynthesis-based algorithm RetroPath. Our database for reactions processed by sequences in heterologous pathways was screened against the PatSeq database, a comprehensive collection of more than 150M sequences present in patent grants and applications. We also examine related patent families using Derwent Innovations. This large-scale computational study provides useful insights into the IP landscape of synthetic biology for fine and specialty chemicals production.

SYNBIOCHEM-a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals.

The Manchester Synthetic Biology Research Centre (SYNBIOCHEM) is a foundry for the biosynthesis and sustainable production of fine and speciality chemicals. The Centre's integrated technology platforms provide a unique capability to facilitate predictable engineering of microbial bio-factories for chemicals production. An overview of these capabilities is described.

Science system path-dependencies and their influences: nanotechnology research in Russia.

In this paper, we study the influence of path dependencies on the development of an emerging technology in a transitional economy. Our focus is the development of nanotechnology in Russia in the period between 1990 and 2012. By examining outputs, publication paths and collaboration patterns, we identify a series of factors that help to explain Russia's limited success in leveraging its ambitious national nanotechnology initiative. The analysis highlights four path-dependent tendencies of Russian nanotechnology research: publication pathways and the gatekeeping role of the Russian Academy of Sciences; increasing geographical and institutional centralisation of nanotechnology research; limited institutional diffusion; and patterns associated with the internationalisation of Russian research. We discuss policy implications related to path dependence, nanotechnology research in Russia and to the broader reform of the Russian science system.

Use of web mining in studying innovation.

As enterprises expand and post increasing information about their business activities on their websites, website data promises to be a valuable source for investigating innovation. This article examines the practicalities and effectiveness of web mining as a research method for innovation studies. We use web mining to explore the R&D activities of 296 UK-based green goods small and mid-size enterprises. We find that website data offers additional insights when compared with other traditional unobtrusive research methods, such as patent and publication analysis. We examine the strengths and limitations of enterprise innovation web mining in terms of a wide range of data quality dimensions, including accuracy, completeness, currency, quantity, flexibility and accessibility. We observe that far more companies in our sample report undertaking R&D activities on their web sites than would be suggested by looking only at conventional data sources. While traditional methods offer information about the early phases of R&D and invention through publications and patents, web mining offers insights that are more downstream in the innovation process. Handling website data is not as easy as alternative data sources, and care needs to be taken in executing search strategies. Website information is also self-reported and companies may vary in their motivations for posting (or not posting) information about their activities on websites. Nonetheless, we find that web mining is a significant and useful complement to current methods, as well as offering novel insights not easily obtained from other unobtrusive sources.

Is there a relationship between research sponsorship and publication impact? An analysis of funding acknowledgments in nanotechnology papers.

This study analyzes funding acknowledgments in scientific papers to investigate relationships between research sponsorship and publication impacts. We identify acknowledgments to research sponsors for nanotechnology papers published in the Web of Science during a one-year sample period. We examine the citations accrued by these papers and the journal impact factors of their publication titles. The results show that publications from grant sponsored research exhibit higher impacts in terms of both journal ranking and citation counts than research that is not grant sponsored. We discuss the method and models used, and the insights provided by this approach as well as it limitations.

The use of environmental, health and safety research in nanotechnology research.

Environmental, health, and safety (EHS) concerns are receiving considerable attention in nanoscience and nanotechnology (nano) research and development (R&D). Policymakers and others have urged that research on nano's EHS implications be developed alongside scientific research in the nano domain rather than subsequent to applications. This concurrent perspective suggests the importance of early understanding and measurement of the diffusion of nano EHS research. The paper examines the diffusion of nano EHS publications, defined through a set of search terms, into the broader nano domain using a global nanotechnology R&D database developed at Georgia Tech. The results indicate that nano EHS research is growing rapidly although it is orders of magnitude smaller than the broader nano S&T domain. Nano EHS work is moderately multidisciplinary, but gaps in biomedical nano EHS's connections with environmental nano EHS are apparent. The paper discusses the implications of these results for the continued monitoring and development of the cross-disciplinary utilization of nano EHS research.