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1.
Am J Surg ; 225(4): 775-780, 2023 04.
Artículo en Inglés | MEDLINE | ID: mdl-36253316

RESUMEN

INTRODUCTION: Natural disasters may lead to increases in community violence due to broad social disruption, economic hardship, and large-scale morbidity and mortality. The effect of the COVID-19 pandemic on community violence is unknown. METHODS: Using trauma registry data on all violence-related patient presentations in Connecticut from 2018 to 2021, we compared the pattern of violence-related trauma from pre-COVID and COVID pandemic using an interrupted time series linear regression model. RESULTS: There was a 55% increase in violence-related trauma in the COVID period compared with the pre-COVID period (IRR: 1.55; 95%CI: 1.34-1.80; p-value<0.001) driven largely by penetrating injuries. This increase disproportionately impacted Black/Latinx communities (IRR: 1.61; 95%CI: 1.36-1.90; p-value<0.001). CONCLUSION: Violence-related trauma increased during the COVID-19 pandemic. Increased community violence is a significant and underappreciated negative health and social consequence of the COVID-19 pandemic, and one that excessively burdens communities already at increased risk from systemic health and social inequities.


Asunto(s)
COVID-19 , Heridas Penetrantes , Humanos , COVID-19/epidemiología , Connecticut/epidemiología , Pandemias , Violencia
2.
Am Surg ; 88(12): 2802-2806, 2022 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-36320095

RESUMEN

In 1998, a Wyoming cyclist noticed what he initially thought was a scarecrow was actually a person. When he took the time to investigate, he found Matthew Shepherd bound to a fence, beaten and left for dead, attacked for being gay. This heinous act of hatred represented a shift in how the United States treats hate crimes, leveeing severe ramifications for the motivations themselves. Although progress has been made, many in medicine who identify in as LGBTQI+ choose to conceal their truths out of fear. With available evidence suggesting a worsening shortage of surgeons in the country, populations of interested people cannot be excluded. Data on representation is severely lacking but is key to attract candidates; inclusivity, modern vocabularies, and the demonstration of engagement are important. Surgical organizations must understand the importance of being a welcoming, mentoring, and allying environment for interested LGBTQI+ candidates, serving as beacons for their interest, or we will simply remain complicit in seeing only scarecrows.


Asunto(s)
Víctimas de Crimen , Odio , Masculino , Humanos , Estados Unidos , Crimen
3.
Injury ; 53(12): 4013-4019, 2022 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-36210206

RESUMEN

BACKGROUND: New Chest Wall Injury and Reconstructive Centers (CWIRC) are emerging; this study aims to investigate the potential benefits of implementing a CWIRC at a single institution. We hypothesized that patients treated at CWIRC will have improved outcomes. METHODS: We instituted a CWIRC in 2019 at our American College of Surgeons (ACS) Level One Trauma Center. We retrospectively compared trauma patients with rib fractures who presented to our center 18 months before (PRE-C) and 18 months after CWIRC implementation (POST-C). Outcomes measured included mortality, length of stay (LOS), intensive care unit (ICU-LOS), readmission rates, and unplanned ICU admission. RESULTS: There were 192 PRE-C patients, compared to 388 POST-C. The mortality in PRE-C was not significantly different compared to the POST-C group (11.46% vs 8.8%, p=0.308). There were also no differences in LOS, ICU-LOS, readmission, and unplanned ICU admission. ICU utilization was dramatically different: PRE-C 17.8% were admitted to ICU compared to 35.6% POST-C (p<0.0001). CONCLUSIONS: The number of patients admitted with rib fractures to our center nearly doubled after CWIRC establishment. Early diagnosis and triage led to significantly more admissions to higher levels of care. There are trends toward improved outcomes using practice management protocols, albeit with higher ICU utilization. Establishment of a CWIRC should be considered for level 1 ACS trauma centers and as utilization of established CWIRC protocols are increased, patients will have improved outcomes. LEVEL OF EVIDENCE: IV STUDY TYPE: Retrospective chart review.


Asunto(s)
Fracturas de las Costillas , Traumatismos Torácicos , Pared Torácica , Humanos , Fracturas de las Costillas/cirugía , Estudios Retrospectivos , Pared Torácica/cirugía , Traumatismos Torácicos/diagnóstico , Centros Traumatológicos , Tiempo de Internación , Puntaje de Gravedad del Traumatismo
4.
World J Surg ; 46(11): 2625-2631, 2022 11.
Artículo en Inglés | MEDLINE | ID: mdl-35854014

RESUMEN

BACKGROUND: Bedside percutaneous dilatational tracheostomy (PDT) and percutaneous endoscopic gastrostomy (PEG) are common procedures performed in the intensive care unit (ICU). Venous thromboembolism (VTE) prophylaxis is frequently prescribed to ICU patients and it remains unclear whether pre-procedure discontinuation is necessary. METHODS: This multi-center prospective observational study aimed to describe bleeding rates in patients undergoing bedside PEG or PDT who did or did not have VTE prophylaxis held. Decision to hold prophylaxis was made by the operating physician. The primary endpoint was the rate of peri-procedural bleeding complications. Secondary endpoints included quantification of held doses in the peri-procedural period, rate of venous thromboembolism, and characteristics associated with having prophylaxis held. RESULTS: 91 patients were included over a 2-year period. Patients were on average aged 54 years, 40% female, mostly admitted to the trauma service (59%), and most commonly underwent bedside PDT (59%). Overall, 21% of patients had doses of pre-procedure prophylaxis held. Bleeding events occurred in 1 patient (1.4%) who had prophylaxis continued and in 1 patient (5.0%) who had prophylaxis held, a rate difference of 3.6% (95% CI-9.5%, 16.7%). One bleeding event was managed with bedside surgical repair and one with blood transfusion. There were 10 VTE events, all of whom had prophylaxis continued during the pre-procedure period but 3 had prophylaxis held after the procedure. CONCLUSIONS: Bleeding complications were rare and did not significantly differ depending on whether prophylaxis was held or not. Future research is required to confirm the lack of risk with continuing prophylaxis through bedside procedures.


Asunto(s)
Tromboembolia Venosa , Anticoagulantes/efectos adversos , Femenino , Humanos , Masculino , Estudios Prospectivos , Traqueostomía/métodos , Tromboembolia Venosa/etiología , Tromboembolia Venosa/prevención & control
5.
Cureus ; 13(10): e18630, 2021 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-34786230

RESUMEN

Introduction Trauma patients frequently return to an emergency department (ED) soon after discharge; often for non-urgent reasons. Social factors contribute to higher ED usage. At present, there is no standardized system for reporting of ED visits and readmissions among trauma care. We hypothesized that victims of violent crime suffer from many early post-discharge adverse events that has not been captured by current methods. Methods We prospectively consented and enrolled injured patients from January 1st, 2019 to December 31st, 2019. We documented 30-day post-discharge events using post-discharge phone calls and detailed chart abstraction. Patients were categorized as victims of violence (VV) or unintentional traumatic injury (UT). Results During the study period, 444 patients were enrolled. Fifty-one (11.5%) were victims of violence and 393 (88.5%) experienced unintentional injuries. The VV patients were younger (40.10 vs 60.36; p<0.0001), and more predominantly male (92.16% vs 57.51%; p<0.0001). Total injury severity score (ISS), critical care length of stay (LOS), and total LOS were similar. VV patients were more likely discharged home (70.59% vs 55.47%; p=0.0403). They were significantly more likely to return to an emergency department (47.06% vs 23.16%; p<0.0005) and had more total number of ED visits per patient. Readmission rates, however, were not different (21.57% vs 16.28%; p=NS). The VV patients more frequently were underinsured (72.5%, vs 20.6%, p<0.005). Discussion Victims of violence presented to the ED significantly more often, despite similar injury scores, LOS, and being of younger age. Of these patients, only 26.2% of ED presentations resulted in readmission, suggesting the majority of patient complaints may have been able to be managed in an office-based setting. VV had significantly more underinsured or subsidized patients. Victims of violence are vulnerable and may benefit from more resources provided in the early post-discharge period.

6.
Cureus ; 13(10): e18789, 2021 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-34804655

RESUMEN

Introduction Firearm homicide is a leading cause of violence-related death in the United States.Unfortunately, more than 80% of illegal firearm discharges are never reported to police by traditional means.ShotSpotterTM (Newark, California) is an acoustic firearm event detection system that can localize gunfire, prompting police, and subsequent emergency medical services (EMS) presence. Previously reported healthcare effects of acoustic detection are speculative in nature. We sought to investigate Hartford, Connecticut's experience with ShotSpotter​​​​​​​TM given its smaller size and broad coverage.  Methods The three trauma centers in Hartford (two for adults and one for pediatric) collaborated with the Hartford Police to review outcomes of victims with acoustically detected gunshots and compare them to those who went undetected. We performed a retrospective review of patients who presented with gunshot wounds (GSW) over a 30-month period, from January 1, 2016 to June 30, 2018. Victim location and acoustic detection were reconciled by the police department and hospital staff independently. Patients were individually matched for location, prehospital response, treatment durations, and hospital outcomes. Results Of 387 GSW, 157 (40.6%) presented via EMS and were included in the sample. Of these, 89 correlated to a detection event (56.7%) and 68 had no correlating event (43.3%). These two groups had no difference in prehospital treatment times, scene and transport duration, and injury severity. Further, the need for surgery or transfusion, lengths of stay, and disposition, including mortality, did not differ. Conclusions Despite limited previous reports demonstrating conferred benefits to acoustic detection of gunshots, Hartford's experience showed no benefit. The potential for such systems to act as early warning systems is evident but may depend on a city's resources, geography, and technology.

7.
Am J Infect Control ; 48(7): 828-830, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-32505337

RESUMEN

Acute care hospitals are requested to perform ongoing surveillance of all patients undergoing mechanical ventilation for ventilator-associated events (VAEs), a serious and often devastating complication of the life-saving modality. Poor performance metrics in VAE rates were recognized at a tertiary care hospital in Hartford, Connecticut and as a result, a multidisciplinary team was developed in 2015 to analyze hospital and system data. The program utilized a multifaceted approach to reliably identify and subsequently prevent VAEs.


Asunto(s)
Neumonía Asociada al Ventilador , Connecticut , Hospitales Urbanos , Humanos , Unidades de Cuidados Intensivos , Neumonía Asociada al Ventilador/epidemiología , Neumonía Asociada al Ventilador/prevención & control , Respiración Artificial/efectos adversos , Ventiladores Mecánicos
9.
J Trauma Acute Care Surg ; 82(5): 877-886, 2017 05.
Artículo en Inglés | MEDLINE | ID: mdl-28240673

RESUMEN

BACKGROUND: In the United States, there is a perceived divide regarding the benefits and risks of firearm ownership. The American College of Surgeons Committee on Trauma Injury Prevention and Control Committee designed a survey to evaluate Committee on Trauma (COT) member attitudes about firearm ownership, freedom, responsibility, physician-patient freedom and policy, with the objective of using survey results to inform firearm injury prevention policy development. METHODS: A 32-question survey was sent to 254 current U.S. COT members by email using Qualtrics. SPSS was used for χ exact tests and nonparametric tests, with statistical significance being less than 0.05. RESULTS: Our response rate was 93%, 43% of COT members have firearm(s) in their home, 88% believe that the American College of Surgeons should give the highest or a high priority to reducing firearm-related injuries, 86% believe health care professionals should be allowed to counsel patients on firearms safety, 94% support federal funding for firearms injury prevention research. The COT participants were asked to provide their opinion on the American College of Surgeons initiating advocacy efforts and there was 90% or greater agreement on 7 of 15 and 80% or greater on 10 of 15 initiatives. CONCLUSION: The COT surgeons agree on: (1) the importance of formally addressing firearm injury prevention, (2) allowing federal funds to support research on firearms injury prevention, (3) retaining the ability of health care professionals to counsel patients on firearms-related injury prevention, and (4) the majority of policy initiatives targeted to reduce interpersonal violence and firearm injury. It is incumbent on trauma and injury prevention organizations to leverage these consensus-based results to initiate prevention, advocacy, and other efforts to decrease firearms injury and death. LEVEL OF EVIDENCE: Prognostic/epidemiologic study, level I; therapeutic care, level II.


Asunto(s)
Heridas por Arma de Fuego/prevención & control , Consenso , Femenino , Armas de Fuego/estadística & datos numéricos , Humanos , Masculino , Propiedad/estadística & datos numéricos , Política Pública , Seguridad , Sociedades Médicas , Encuestas y Cuestionarios , Traumatología/estadística & datos numéricos , Estados Unidos
10.
Injury ; 48(1): 47-50, 2017 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-27582383

RESUMEN

METHODS: We queried our Trauma Quality Improvement Program registry for patients who presented between 6/1/2011 and 9/1/2015 with severe (injury severity score (ISS)>15) blunt traumatic injury during anticoagulant use. Patients were then grouped into those prescribed warfarin and patients prescribed any of the available novel Direct Oral Anticoagulants (DOAC) medications. We excluded severe (AIS≧4) head injuries. RESULTS: There were no differences between DOAC and warfarin groups in terms of age, gender mean ISS, median hospital or intensive care unit lengths of stay, complication proportions, numbers of complications per patient, or the proportion of patients requiring transfusion. Finally, excluding patients who died, the observed proportion of discharge to skilled nursing facility was similar. In our sample of trauma patients, DOAC use was associated with significantly lower mortality (DOAC group 8.3% vs. warfarin group 29.5%, p<0.015). The ratio of units transfused per patient was also lower in the DOAC group (2.8±1.8 units/patient in the DOAC group vs. 6.7±6.4 units per patient in the warfarin group; p=0.001). CONCLUSION: In conclusion, we report an association with decrease in mortality and a decrease in transfused blood products in severely injured trauma patients with likely minimal or no head injury taking novel DOACs over those anticoagulated with warfarin for outpatient anticoagulation.


Asunto(s)
Traumatismos Abdominales/terapia , Anticoagulantes/efectos adversos , Traumatismos Craneocerebrales/terapia , Hemorragia/prevención & control , Centros Traumatológicos , Warfarina/efectos adversos , Heridas no Penetrantes/terapia , Traumatismos Abdominales/complicaciones , Traumatismos Abdominales/mortalidad , Anciano , Pruebas de Coagulación Sanguínea , Traumatismos Craneocerebrales/complicaciones , Traumatismos Craneocerebrales/mortalidad , Femenino , Hemorragia/inducido químicamente , Humanos , Relación Normalizada Internacional , Masculino , Mejoramiento de la Calidad , Sistema de Registros , Estudios Retrospectivos , Índices de Gravedad del Trauma , Estados Unidos , Heridas no Penetrantes/complicaciones , Heridas no Penetrantes/mortalidad
11.
Conn Med ; 81(2): 75-79, 2017 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-29738149

RESUMEN

BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) is frequently performed for delivery of nonoral enteral nutrition (EN) in critically ill patients. Tube-based supplement initiation is often delayed for a variety of reasons despite evidence that EN interruption results in worse outcomes. OBJECTIVE: To determine if early initiation of EN after PEG placement is safe and well-tolerated in critically ill patients and if early initiation of EN results in more goal-accomplished days of EN. DESIGN: A retrospective chart review of patients who underwent PEG and at least 24 hours of EN. Patients were stratified according to time to tube- feed initiation: immediate (< one hour), early (one to four hours), and late (four to 24 hours). RESULTS: 'Ihe three groups were similar with respect to demographics, comorbidities, and 30-day mortality. Sixty-one percent of patients in the immediate group were advanced to the previously-met goal EN rates compared to 24% and 18% in the early and delayed groups, respectively (P < .0001). CONCLUSION: Immediate reinitiation of nonoral EN after PEG procedure is safe and is associated with reaching goal nutrition faster.


Asunto(s)
Enfermedad Crítica , Nutrición Enteral , Gastrostomía , Intubación Gastrointestinal , Nutrición Enteral/instrumentación , Nutrición Enteral/métodos , Nutrición Enteral/mortalidad , Femenino , Gastrostomía/métodos , Objetivos , Humanos , Intubación Gastrointestinal/métodos , Masculino , Persona de Mediana Edad , Evaluación de Resultado en la Atención de Salud , Estudios Retrospectivos
12.
Conn Med ; 80(4): 197-203, 2016 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-27265921

RESUMEN

BACKGROUND: Catheter-associated urinary tract infections (CAUTI) have been associated with increases in morbidity and mortality as well as increased costs of hospitalization. At our institution, we implemented a protocol for indwelling catheter use, maintenance, and removal based on Center for Medicare and Medicaid Services (CMS) guidelines, in efforts to reduce CAUTI rates. METHODS: A hospital committee of quality stewards focused on several measures which included staff education, modification of existing systems to ensure compliance, and auditing of patient care areas for catheter utilization before implementation of the protocol. Pre- and postintervention postoperative cohorts were then identified through American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) for prevalence of CAUTI. Data were collected through chart review and postdischarge patient interviews. RESULTS: A total of 3873 patients were identified between September 2007 and December 2010. Thirty-six patients (2.6%) were diagnosed with a CAUTI in the preintervention group (N = 1404) compared to 38 (1.5%) patients who were diagnosed with a CAUTI in the postintervention group (N = 2469). There was a 1.1% decrease in CAUTI rate after protocol implementation (P < .028). This reduction in rates resulted in annual estimated savings of $81,840 to $320,540 annually. CONCLUSION: A simple, multifaceted approach consisting of staff education and changing existing processes to reflect best care practices has the potential to significantly reduce the incidence of postoperative CAUTI.


Asunto(s)
Infecciones Relacionadas con Catéteres/prevención & control , Catéteres de Permanencia/efectos adversos , Complicaciones Posoperatorias/prevención & control , Cateterismo Urinario/efectos adversos , Infecciones Urinarias/prevención & control , Protocolos Clínicos , Connecticut , Infección Hospitalaria/prevención & control , Femenino , Humanos , Control de Infecciones , Masculino , Persona de Mediana Edad
13.
J Am Coll Surg ; 222(5): 865-9, 2016 05.
Artículo en Inglés | MEDLINE | ID: mdl-27016899

RESUMEN

BACKGROUND: Traumatic injury remains the leading cause of preventable morbidity and mortality worldwide, with a large economic burden. One fourth of annual Medicare expenditures result from readmissions, including trauma. The American College of Surgeons Trauma Quality Improvement Program (ACS TQIP) has elevated care for >200 trauma programs worldwide. We use ACS TQIP, which does not include 30-day outcomes featured in the ACS NSQIP, affecting observed readmission rates. STUDY DESIGN: Trauma patients were subjected to the 30-day follow-up with the ACS NSQIP tools to assess readmission rates. The existing standard hospital and trauma registry data review was used to determine readmission, with the same group assessed for readmission using the information collected with the modified TQIP tools. All data collected via this method were patient reported and verified by review of records at our facility and via patient-authorized outside record review. RESULTS: Six hundred and ninety-eight consecutive patients were admitted to the trauma service during the study period and 378 (54.1%) were contacted by telephone for interview. Demographic characteristics were similar (p = NS). The readmission rate changed from 4.01% to 2.4% using the hospital and trauma registry subset (p = NS). Readmission rate by the modified TQIP method was 7.1% (p < 0.03). Readmitted patients did not differ with respect to routine follow-up visits. CONCLUSIONS: We hypothesized that our observed and actual readmission rates differed. We discovered a significant difference in reported rates. Incorporating an NSQIP-like postdischarge feedback process can improve the accuracy of hospitals' readmission data and complication reporting, and thereby improve the value of the information TQIP uses as benchmarks.


Asunto(s)
Readmisión del Paciente/estadística & datos numéricos , Mejoramiento de la Calidad/normas , Heridas y Lesiones/terapia , Anciano , Connecticut , Femenino , Humanos , Entrevistas como Asunto , Masculino , Persona de Mediana Edad , Evaluación de Resultado en la Atención de Salud , Estudios Retrospectivos , Heridas y Lesiones/epidemiología
14.
Conn Med ; 79(8): 493-7, 2015 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-26506682

RESUMEN

BACKGROUND: Surgery is a critical component of global health care worldwide. Little is known about global surgery participation among surgeons in Connecticut. The goal of this pilot survey project was to determine the breadth of global surgery experience in our state. STUDY DESIGN: An electronic survey was distributed to surgeons in the state of Connecticut via the Connecticut Chapter of the American College of Surgeons (CTACS) and to departments of surgery throughout the state. RESULTS: Seventy-four surgeons and surgical residents completed the online survey from 17 different hospitals. Nineteen (25.7%) of the respondents had participated in global surgery. Most participated in yearly (56.3%), short-term experiences (94.5%). Nearly half of this group reported no formal record of outcomes (52.9%), but 17/19 (89.5%) respondents reported that accurate outcomes measures are beneficial to surgical care in resource-poor areas. Eighty-nine percent reported a willingness to participate in a surgical quality and outcomes database. CONCLUSION: A substantial proportion of surgeons in Connecticut participate in global surgery. Most surgeons value qualityin surgical care, yet outcomes are not routinely measured. This discordance may be addressed through the development of a quality improvement collaborative for global surgery.


Asunto(s)
Misiones Médicas , Pautas de la Práctica en Medicina/estadística & datos numéricos , Calidad de la Atención de Salud , Procedimientos Quirúrgicos Operativos/normas , Actitud del Personal de Salud , Connecticut , Conducta Cooperativa , Humanos , Mejoramiento de la Calidad , Encuestas y Cuestionarios
15.
Conn Med ; 77(8): 453-9, 2013 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-24156172

RESUMEN

Gunbuy-backprograms have been proposed as away to remove unwanted firearms from circulation, but remain controversial because their ability to prevent firearm injuries remains unproven. The purpose of this study is to describe the demographics of individuals participating in Connecticut's gun buy-backprogram in the context of annual gun sales and the epidemiology of firearm violence in the state. Over four years the buy-back program collected 464 firearms, including 232 handguns. In contrast, 91,602 firearms were sold in Connecticut during 2009 alone. The incidence of gun-related deaths was unchanged in the two years following the inception of the buy-back program. Suicide was associated with older age (mean = 51 +/- 18years) and Caucasian race (n = 539, 90%). Homicide was associated with younger age (mean = 30 +/- 12 years) and minority race (n = 425, 81%). A gun buy-back program alone is not likely to produce a measurable decrease in firearm injuries and deaths.


Asunto(s)
Participación de la Comunidad/estadística & datos numéricos , Armas de Fuego/estadística & datos numéricos , Homicidio/prevención & control , Prevención Primaria/organización & administración , Prevención del Suicidio , Violencia/prevención & control , Heridas por Arma de Fuego/prevención & control , Adulto , Distribución por Edad , Anciano , Connecticut , Femenino , Armas de Fuego/legislación & jurisprudencia , Homicidio/estadística & datos numéricos , Humanos , Masculino , Persona de Mediana Edad , Características de la Residencia , Suicidio/estadística & datos numéricos , Estados Unidos , Violencia/estadística & datos numéricos , Heridas por Arma de Fuego/epidemiología , Adulto Joven
16.
J Am Coll Surg ; 215(6): 766-76, 2012 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-22951032

RESUMEN

BACKGROUND: Thirty-day postoperative complications from unintended harm adversely affect patients and their families and increase institutional health care costs. A surgical checklist is an inexpensive tool that will facilitate effective communication and teamwork. Surgical team training has demonstrated the opportunity for stakeholders to professionally engage one another through leveling of the authority gradient to prevent patient harm. The American College of Surgeons National Surgical Quality Improvement Program database is an outcomes reporting tool capable of validating the use of surgical checklists. STUDY DESIGN: Three 60-minute team training sessions were conducted and participants were oriented to the use of a comprehensive surgical checklist. The surgical team used the checklist for high-risk procedures selected from those analyzed for the American College of Surgeons National Surgical Quality Improvement Program. Trained observers assessed the checklist completion and collected data about perioperative communication and safety-compromising events. RESULTS: Data from the American College of Surgeons National Surgical Quality Improvement Program were compared for 2,079 historical control cases, 246 cases without checklist use, and 73 cases with checklist use. Overall completion of the checklist sections was 97.26%. Comparison of 30-day morbidity demonstrated a statistically significant (p = 0.000) reduction in overall adverse event rates from 23.60% for historical control cases and 15.90% in cases with only team training, to 8.20% in cases with checklist use. CONCLUSIONS: Use of a comprehensive surgical safety checklist and implementation of a structured team training curriculum produced a statistically significant decrease in 30-day morbidity. Adoption of a comprehensive checklist is feasible with team training intervention and can produce measurable improvements in patient outcomes.


Asunto(s)
Lista de Verificación , Implementación de Plan de Salud/organización & administración , Grupo de Atención al Paciente/normas , Seguridad del Paciente/normas , Complicaciones Posoperatorias/prevención & control , Administración de la Seguridad/métodos , Procedimientos Quirúrgicos Operativos/normas , Connecticut/epidemiología , Femenino , Mortalidad Hospitalaria/tendencias , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Quirófanos/normas , Complicaciones Posoperatorias/epidemiología , Estudios Prospectivos
18.
Crit Care Clin ; 26(2): 285-93, table of contents, 2010 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-20381720

RESUMEN

The Surviving Sepsis Campaign targets central venous pressure, mean arterial pressure, and central venous oxygen saturation as guides for resuscitation. Fluid resuscitation and the use of vasopressors are paramount to the success of the campaign's end points. Although the achievement of supranormal physiologic parameters has been associated with higher mortality in some studies, these slightly higher blood pressures may enable better oxygen delivery, in some observations. This article focuses on the mean arterial pressure goals during sepsis, the measurement of the mean arterial pressure, and the manipulation of this target with volume resuscitation and pharmacologic interventions.


Asunto(s)
Choque Séptico/fisiopatología , Choque Séptico/terapia , Presión Sanguínea/efectos de los fármacos , Cardiotónicos/uso terapéutico , Presión Venosa Central/efectos de los fármacos , Dopamina/uso terapéutico , Fluidoterapia , Humanos , Oxígeno/sangre , Consumo de Oxígeno/efectos de los fármacos , Fenilpropanolamina/uso terapéutico , Choque Séptico/tratamiento farmacológico , Simpatomiméticos/uso terapéutico , Vasoconstrictores/uso terapéutico
19.
Crit Care Clin ; 26(2): 409-21, table of contents, 2010 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-20381729

RESUMEN

Organ function is critically linked to the way tissues use available oxygen. In sepsis, tissue-related hypoxic injury is the result of hypoxemia and hypoperfusion and cytokine-mediated mitochondrial dysfunction termed cytopathic hypoxia. Organ dysfunction in sepsis is more likely related to derailment of the metabolic processes of cells to use available oxygen. Cellular dysoxia rather than hypoxia may be the most appropriate way of describing sepsis-related tissue injury. Lactate is a marker of aerobic mitochondrial dysfunction and anaerobic tissue metabolism and in some circumstances is considered the fuel of choice for certain tissues. The concept of cellular metabolic derangement or cytopathic hypoxia as a potential cause for multiorgan system dysfunction in sepsis may direct efforts to optimize outcome in septic patients from the classic targets of CO, tissue perfusion, DVo(2), and Vo(2) toward moderating sepsis-related early cytokine response, maximizing mitochondrial function, and using biomarkers to monitor treatment response.


Asunto(s)
Insuficiencia Multiorgánica/patología , Sepsis/patología , Acidosis Láctica/sangre , Biomarcadores/metabolismo , Hipoxia de la Célula/fisiología , Humanos , Mitocondrias/metabolismo , Insuficiencia Multiorgánica/metabolismo , Óxido Nítrico/biosíntesis , Consumo de Oxígeno , Sepsis/metabolismo
20.
J Thorac Cardiovasc Surg ; 124(1): 162-70, 2002 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-12091822

RESUMEN

BACKGROUND: All forms of surgical therapy are stressful and injurious. The problems of paralysis, renal dysfunction, and colonic ischemia associated with aortic occlusion are due to acute ischemia-reperfusion injury at the cellular level. Acute-anterior spinal cord ischemia is the most devastating outcome of these iatrogenic-ischemic events. The majority of surgical procedures are performed electively and therefore provide an opportunity to preoperatively condition the patient to minimize these ischemia-related morbidities. OBJECTIVES: We sought to determine whether acute spinal cord injury associated with aortic occlusion can be prevented by induction of the cellular stress response by means of preoperative administration of whole-body hyperthermia or stannous chloride. METHODS: The study consisted of an experimental rabbit model of infrarenal aortic occlusion for 20 minutes at normothermic body temperature. RESULTS: Control rabbits experienced an 88% (7/8) incidence of paralysis after spinal cord ischemia induced by 20 minutes of aortic occlusion, whereas animals treated preoperatively with either whole-body hyperthermia (0/9) or stannous chloride (0/4) never became paralyzed (P <.001 for control vs treated groups). Ischemic protection of the spinal cord was associated with increased content of stress proteins within tissues of pretreated animals. CONCLUSION: Prior induction of the heat shock response in the whole animal will increase the content of stress proteins within the spinal cord and other tissues and result in the prevention of hind-limb paralysis associated with aortic occlusion. We have designated the preoperative induction of the cellular stress response for the prevention of ischemic tissue injury stress conditioning. We suggest that stress-conditioning protocols represent the opportunity to practice preventative medicine at the molecular level.


Asunto(s)
Aorta Abdominal/cirugía , Proteínas de Choque Térmico/metabolismo , Precondicionamiento Isquémico , Paraplejía/prevención & control , Isquemia de la Médula Espinal/prevención & control , Animales , Western Blotting , Femenino , Proteínas de Choque Térmico/genética , Miembro Posterior , Hipertermia Inducida , Conejos , Factores de Tiempo , Compuestos de Estaño/farmacología
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