1.
Bioorg Med Chem Lett
; 12(17): 2475-8, 2002 Sep 02.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12161161
RESUMEN
A systematic structure-activity relationship investigation of the lead compound 1 resulted the identification of several N-[(substituted alkyl)cycloalkanoyl]-4-[((2,6-dichlorophenyl)carbonyl)amino]-L-phenylalanine derivatives as potent VCAM/VLA-4 antagonists. The data are consistent with a model of these compounds in which these alkanoylphenylalanines reside in a compact gauche (-) bioactive conformation.
