Immunological features of Wegener´s granulomatosis

A number of immunological markers were studied in ten patients with Wegener´s granulomatosis or non-healing midline granuloma. The concentration of serum IgA and C3 were increased. Autoantibodies to smooth muscle were showed a lack of correlation between and intact macrophage migration inhibition function and impaired skin delayed hypersensitivity and lymphocyte transformation to a number of antigens. It is suggested that Wegener´s granulomatosis may be associated with a partial, cell-mediated immunodeficiency.