RESUMEN
The perspectives of use of porous polytetrafluorethilen (PTPE) with modified surface combined with mesenchymal stem cells for tissue-engineering constructions were studied. The paper also describes the mode of PTPE surface modification consisting in nanostructured metallic or ceramic layer application resulting in biocompatibility and surface adhesion rates increase. The magnetic atomizing of Ti and Ti-Ca-P-C-O-N nanolayers enhances the material integration potential as well as adhesion rates thus making it perspective when combined with mesenchymal stem cells for bone defects plasty.
Asunto(s)
Materiales Biocompatibles Revestidos , Implantación de Prótesis Maxilofacial , Nanoestructuras , Politetrafluoroetileno , Ingeniería de Tejidos , Andamios del Tejido , Adhesión Celular , Células Cultivadas , Humanos , Células Madre Mesenquimatosas/citología , Células Madre Mesenquimatosas/fisiología , Aleaciones de Cerámica y MetalRESUMEN
The authors developed new material based upon polytetrafluoroethylene (Teflon) with nanostructured metal and ceramic coatings. The task was formulated to study integrating potential of different chemical composition surfaces of intraosseous implants using Teflon with the mentioned above coatings as the experimental model. In experiments on rats using histomorphologic criterion there were compared implants from Teflon with Ti-, Ti-Ca-P-C-O-N- and Ti-Ca-Mn-K-C-O-N-coatings and Teflon without coating as the group for reference. It was shown that new experimental implant model based upon Teflon with different nanostructured coatings opened the possibility to profound investigation of interface contact substrate of metal (ceramic) surface with surrounding tissue structures. Optimal results upon the osteointegration criterion were received with Teflon + Ti-Ca-P-C-O-N-coating.