Comparative Diagnosis of the Urban Noise Problem from Infrastructural and Social Sensing Approaches: A Case Study in Ningbo, China.

Urban noise causes a variety of health problems, and its prevention and control have thus become an important research topic in urban governance. Although existing literature is fairly comprehensive in revealing the physical noise patterns, it lacks the concern of people's perceived seriousness, especially at the macroscopic, i.e., citywide scale. In this paper, we borrow from the "exposure-perception-behavior" theory in environmental psychology, and propose an analytical framework for diagnosing the urban noise problem that integrates the Infrastructural and Social Sensing perspectives. Utilizing noise monitoring data that fills the spatiotemporal granularity gaps of official noise monitoring, as well as the "12345" urban complaint hotline records which serve as a proxy for residents' perceived noise levels, we empirically examine the mechanisms for physical magnitude and perceived seriousness of urban noise, respectively, by taking the Jiangbei District of Ningbo City, China as an example. Results show that the existence of perceptual bias and behavioral preference effects did shape people's perceived noise problem map that is vastly different from that of the physical noise magnitude, in which the semantics of urban places, temporal rhythms of life, and population demographics significantly influenced people's tolerance of noise. We conclude the paper with suggestions on updating the existing National Standard for urban noise regulation to reflect the perceptual aspect, and also methodological discussions on possible ways to recognize and utilize the perceptual bias in social-sensing big-data to better accommodate urban governance.

CARD11 alteration as a candidate biomarker of skin cutaneous melanoma treated with immune checkpoint blockade.

BACKGROUND: Immune checkpoint inhibitors (ICIs) can be problematic, including a lack of sustained clinical response, in the treatment of skin cutaneous melanoma (SKCM) patients; therefore, predictive biomarkers are urgently needed. Recently, gene mutations identified by melanoma genomic analysis have shown great predictive potential. METHODS: We collected an immunotherapy cohort and The Cancer Genome Atlas (TCGA)-SKCM cohort from published studies and tested the predictive function of the CARD11 mutation. We then further studied the association between the CARD11 mutation and tumor immunogenicity by studying related genes and pathways in the tumor microenvironment (TME). RESULTS: In the immunotherapy and TCGA-SKCM cohorts, patients with CARD11-mutant (MT) tumors had longer overall survival (OS) and a better prognosis than those with CARD11-wild-type (WT) tumors. CARD11-MT tumors had higher immunogenicity, and gene expression related to immunosuppression was significantly downregulated in CARD11-MT tumors. We found that immunosuppression-related pathways were significantly downregulated in CARD11-MT tumors, while immune activation-related pathways were significantly upregulated. Additionally, CARD11-MT tumors had more DNA damage response and repair (DDR) pathway mutations. CONCLUSIONS: CARD11 mutation is associated with longer OS and a better prognosis after ICI treatment. Therefore, the CARD11 gene can be used as a biomarker for predicting the efficacy of ICIs in SKCM patients.