1.
J Med Chem
; 51(6): 1577-83, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE
| ID: mdl-18288795
RESUMEN
A series of methylated imidazolium salts with varying substituents on the 4 and 5 positions of the imidazole ring were synthesized. These salts were reacted with silver acetate to afford their corresponding silver N-heterocyclic carbene (NHC) complexes. These complexes were then evaluated for their stability in water as well as for their antimicrobial efficacy against a variety of bacterial strains associated with cystic fibrosis and chronic lung infections.