RESUMEN
Intoxication, by cyanurate and its chlorated derivatives in children, is increasingly reported in the literature due to accidental ingestion compared to accidental inhalation. We report a case in a 5-year-old child who presented with acute lung injury due to accidental inhalation of gas formed after a reaction of sodium dichloroisocyanurate tablets with water. Prevention remains the best way to reduce the risk of children being intoxicated by inhalation of the gas formed after contact of tablets with water.
Asunto(s)
Lesión Pulmonar Aguda/inducido químicamente , Edema Pulmonar/inducido químicamente , Triazinas/envenenamiento , Preescolar , Femenino , Gases , Humanos , AguaRESUMEN
Postpartum haemorrhage is the leading cause of maternal death in France and worldwide. Guidelines help to conduct a timed management and to reduce maternal morbidity and mortality. Rescue and surgical care, transfusion and monitoring have to be previously organized.
Asunto(s)
Transfusión Sanguínea , Hemorragia Posparto/terapia , Anemia Ferropénica/tratamiento farmacológico , Anemia Ferropénica/prevención & control , Biomarcadores/sangre , Bancos de Sangre/organización & administración , Trastornos de la Coagulación Sanguínea/complicaciones , Parto Obstétrico/métodos , Urgencias Médicas , Femenino , Fibrinólisis , Hemostáticos/uso terapéutico , Humanos , Oxitocina/uso terapéutico , Hemorragia Posparto/diagnóstico , Hemorragia Posparto/tratamiento farmacológico , Hemorragia Posparto/etiología , Hemorragia Posparto/mortalidad , Guías de Práctica Clínica como Asunto , Embarazo , Complicaciones Hematológicas del Embarazo/tratamiento farmacológico , Complicaciones Hematológicas del Embarazo/prevención & controlAsunto(s)
Colitis/inducido químicamente , Duodeno/efectos de los fármacos , Duodeno/patología , Fibrinolíticos/efectos adversos , Linfocitos/patología , Ticlopidina/efectos adversos , Anciano , Anciano de 80 o más Años , Arteritis/tratamiento farmacológico , Atrofia , Enfermedad Crónica , Colitis/inmunología , Colitis/patología , Diarrea/etiología , Femenino , HumanosRESUMEN
Although it has been established that liver failure is associated with arterial hypocapnia and alkalaemia (i.e., respiratory alkalosis), the influence of liver failure on mixed venous acid-base status has not yet been studied. Thus, arterial and mixed venous acid-base status were simultaneously measured in controls and in a large series of patients with cirrhosis. Grade B patients (n = 28) or Grade C patients (n = 21) had significantly lower arterial and mixed venous carbon dioxide tensions than controls (n = 29). Grade B or Grade C patients also had significantly higher arterial, mixed venous pH, and lower mixed venous bicarbonate concentrations than controls. Among Grade A patients (n = 27), those with the lowest Pugh's score (i.e., equal to five) had significantly lower mixed venous carbon dioxide tension than controls. The other arterial and mixed venous acid-base values did not differ significantly between Grade A patients with the lowest Pugh's score and controls. Grade A patients with a Pugh's score equal to six and Grade B patients had similar acid-base disorders. No significant differences were found between groups concerning the anion gap and plasma chloride concentrations. In conclusion, this study shows that in Grade B or C patients, respiratory alkalosis was responsible for mixed venous hypocapnia, alkalaemia and hypobicarbonataemia. In addition, in Grade A patients with the lowest Pugh's score (equal to five), analysis of arterial and mixed venous blood revealed that mixed venous hypocapnia was the sole anomaly of the acid-base status. This last finding suggests that mixed venous hypocapnia might be an early event preceding the onset of arterial hypocapnia.
Asunto(s)
Hipocapnia/etiología , Cirrosis Hepática/sangre , Fallo Hepático/sangre , Alcalosis Respiratoria/etiología , Bicarbonatos/sangre , Análisis de los Gases de la Sangre , Femenino , Humanos , Concentración de Iones de Hidrógeno , Cirrosis Hepática/complicaciones , Fallo Hepático/complicaciones , Masculino , Persona de Mediana EdadRESUMEN
During the 26th week of a first pregnancy, a 25-year-old woman presented with pruritus suggesting an intrahepatic cholestasis of pregnancy. The pruritus, however, persisted despite the premature delivery of a normal newborn at the 35th week. Moreover, aspartate aminotransferase activity increased, reaching a maximum of 38 times normal level on the 17th day after the delivery. Thus, an acute fatty liver of pregnancy was suspected and confirmed by liver biopsy. This patient appeared to have both intrahepatic cholestasis of pregnancy and acute fatty liver of pregnancy, an association not previously reported. It is suggested that intrahepatic cholestasis of pregnancy caused premature delivery, which in turn may have prevented the onset of severe maternal and fetal complications caused by acute fatty liver of pregnancy.
Asunto(s)
Colestasis Intrahepática/complicaciones , Hígado Graso/complicaciones , Complicaciones del Embarazo/diagnóstico , Adulto , Colestasis Intrahepática/diagnóstico , Hígado Graso/diagnóstico , Femenino , Humanos , Pruebas de Función Hepática , Embarazo , Prurito/diagnóstico , Prurito/etiologíaRESUMEN
In patients with cirrhosis, vasopressin infusion induces sustained vasoconstriction and elevation of arterial pressure. The vasopressor effect could be caused by impairment of mechanisms normally aimed at buffering increases in arterial pressure (reflex bradycardia and decreases in arteriolar resistance). We studied the acute effects of continuous vasopressin infusion (0.4 IU/min) on systemic hemodynamics in seven patients with cirrhosis and in six patients without cirrhosis (controls). Vasopressin effects on systemic O2 consumption were also studied. In both groups, vasopressin infusion induced similar peak increases in arterial pressure, followed by similar decreases in heart rate and cardiac output. However, cirrhotic patients and controls differed 30 min after the start of vasopressin infusion. At 30 min, mean arterial pressure, diastolic arterial pressure and systemic vascular resistance remained significantly higher than preinfusion values in patients with cirrhosis. No decrease in systemic O2 consumption occurred in cirrhotic patients. In controls, at 30 min, mean arterial pressure and diastolic arterial pressure had returned to baseline. Systemic vascular resistance was not significantly higher than the preinfusion value and systemic O2 consumption had significantly decreased to below preinfusion values. We conclude that the vasopressor effect of vasopressin is abnormally sustained in patients with cirrhosis. This might be caused by insufficient buffering of vasopressin-induced arteriolar constriction rather than by abnormal vagal control of heart rate. In turn, as suggested by the lack of a decrease in systemic O2 consumption, persistent arteriolar constriction might be related to abnormally sustained sympathetic vascular tone in patients with cirrhosis.
Asunto(s)
Hemodinámica/efectos de los fármacos , Cirrosis Hepática/fisiopatología , Lipresina/farmacología , Potasio/sangre , Sodio/sangre , Adulto , Presión Sanguínea/efectos de los fármacos , Femenino , Frecuencia Cardíaca/efectos de los fármacos , Humanos , Infusiones Intravenosas , Lipresina/administración & dosificación , Masculino , Consumo de Oxígeno/efectos de los fármacos , Valores de Referencia , Resistencia Vascular/efectos de los fármacosRESUMEN
Systemic haemodynamic and hepatic venous pressures, arterial and mixed venous gases and arterial lactate concentration were measured in 35 patients with histologically proven alcoholic cirrhosis who had been classified into three groups (A, B and C). Eight alcoholic patients without cirrhosis on liver biopsy were also studied. Compared with group A patients, group C patients had significantly higher hepatic venous pressure gradient, cardiac index, O2 transport and arterial lactate concentration and significantly lower systemic vascular resistance, arteriovenous O2 content difference and O2 uptake. In group B patients, corresponding values fell between those of groups A and C. Group A patients, unlike group C patients, were not significantly different from patients without cirrhosis with respect to cardiac index, systemic vascular resistance, O2 uptake and arterial lactate concentration. Our results suggest that in patients with cirrhosis, liver failure-associated hyperdynamic circulation may be accompanied by an abnormal tissue oxygenation.
Asunto(s)
Cirrosis Hepática Alcohólica/metabolismo , Consumo de Oxígeno , Equilibrio Ácido-Base , Adulto , Femenino , Humanos , Cirrosis Hepática Alcohólica/clasificación , Cirrosis Hepática Alcohólica/fisiopatología , Masculino , Persona de Mediana EdadRESUMEN
The authors report the observations of four patients with iproniazid hepatitis. Three of these patients died. An antimitochondrial antibody was found in the 4 patients at a high titer. This antibody differed from the antimitochondrial antibodies which have been described previously (anti-M1, anti-M5). This new antibody was called anti-M6. The evolution of the anti-M6 titer has been studied in the patient who survived. This titer progressively decreased; the antibody was no longer detectable 6 months after the withdrawal of iproniazid. Anti-M6 has not been found in other hepatic diseases. It was not detected in 15 patients receiving iproniazid without hepatitis or in 6 patients receiving isoniazid. Anti-M6 appears as a useful serologic marker for the diagnosis of iproniazid hepatitis.
Asunto(s)
Anticuerpos/análisis , Enfermedad Hepática Inducida por Sustancias y Drogas/diagnóstico , Iproniazida/efectos adversos , Mitocondrias Hepáticas/inmunología , Adulto , Enfermedad Hepática Inducida por Sustancias y Drogas/etiología , Enfermedad Hepática Inducida por Sustancias y Drogas/patología , Quimioterapia Combinada , Femenino , Humanos , Ictericia/inducido químicamente , Ictericia/diagnóstico , Ictericia/patología , Masculino , Persona de Mediana EdadRESUMEN
We report the cases of four adult patients suffering from acute hepatitis due to isaxonine phosphate (Nerfactor), a drug recently proposed for the treatment of the lesions of peripheral nerves. Hepatitis developed 14 to 166 days after the beginning of the administration of the drug. In all the patients, predominantly centrilobular hepatocytic necrosis was present. In two of our patients, the course of hepatitis was fatal. Hepatitis induced by isaxonine phosphate is likely to be due to an immuno-allergic mechanism.
Asunto(s)
Enfermedad Hepática Inducida por Sustancias y Drogas/etiología , Pirimidinas/efectos adversos , Enfermedad Aguda , Adulto , Anciano , Enfermedad Hepática Inducida por Sustancias y Drogas/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Enfermedades del Sistema Nervioso Periférico/tratamiento farmacológicoRESUMEN
An unusual of bilateral adrenal benign adenoma with Cushing's syndrome is reported. Nine months after bilateral adrenalectomy, no more sign of hyperadrenocorticism was present. An adenoma was found in each gland with adjacent tissue atrophic. Physiopathology is not clear even if suppression test by dexamethasone and stimulation test by lysin-vasopressin are compatible with a central origin.
Asunto(s)
Adenoma/complicaciones , Neoplasias de las Glándulas Suprarrenales/complicaciones , Síndrome de Cushing/etiología , Adenoma/diagnóstico , Neoplasias de las Glándulas Suprarrenales/diagnóstico , Adulto , Síndrome de Cushing/diagnóstico , Femenino , HumanosRESUMEN
Acute fatty infiltration of the liver in pregnancy is characterised by microvacuolar fatty infiltration, without necrosis, occuring at the end of pregnancy. This syndrome, defined by Sheehan in 1940, remains rare. The authors were able to find 62 authentic cases in the french, english and german literature. The course is fatal in 75% of cases for the mother and 70% for the child. The gravity is related to hepatocellular failure, but also to extra-hepatic complications (renal failure, haemorrhagic syndrome, infectious complications, acute haemorrhagic and/or necrosing pancreatitis). When the course is favourable, the hepatic lesions disappear in a few weeks and there is no recurrence during subsequent pregnancies. The histological lesions of acute fatty infiltration of the liver in pregnancy are identical to those of fatty infiltration of the liver induced by cyclines and of Reye syndrome.
Asunto(s)
Hígado Graso/patología , Complicaciones del Embarazo , Enfermedad Aguda , Lesión Renal Aguda/etiología , Adulto , Diagnóstico Diferencial , Coagulación Intravascular Diseminada/etiología , Hígado Graso/diagnóstico , Femenino , Hematemesis/etiología , Encefalopatía Hepática/etiología , Hepatitis Viral Humana/diagnóstico , Humanos , Recién Nacido , Ictericia/etiología , Hígado/patología , Hígado/ultraestructura , Pancreatitis/etiología , Embarazo , Tercer Trimestre del Embarazo , SíndromeRESUMEN
In three patients, the first manifestation of Wilson's disease was a syndrome in which acute intravascular hemolysis and acute liver failure were associated. This syndrome developed in three periods; the first, lasting 3 to 14 days, was characterized by fatigue, fever, and jaundice; the second, lasting 1 or 2 days, by severe intravascular hemolysis; and the third, lasting 2 to 6 days, by hepatic encephalopathy. All of the patients died from liver failure 7 to 21 days after the onset of the syndrome. The association of acute intravascular hemolysis and acute live failure is a characteristic manifestation of Wilson's disease; it is rarely associated with other liver diseases. This association might result from hepatic cell necrosis due to accumulation of copper, the consequences being acute liver failure and destruction of erythrocytes by the large amounts of copper released from the necrotic hepatic cells to the plasma.
Asunto(s)
Hemólisis , Encefalopatía Hepática/etiología , Degeneración Hepatolenticular/complicaciones , Adolescente , Niño , Femenino , Degeneración Hepatolenticular/diagnóstico , Humanos , MasculinoRESUMEN
A controlled study of therapeutic end-to-side portacaval shunt was carried out from 1968 to 1971 in 89 patients with alcoholic cirrhosis. Recurrent gastrointestinal bleeding was less common and chronic hepatic encephalopathy was more common in patients with shunts than in patients without shunts. The survival-rate was lower, but not significantly, in patients with shunts. No overall benefit of the operation could be demonstrated in cirrhotic patients with the selection criteria and the type of surgical shunt used in this study.