PyLEnM: A Machine Learning Framework for Long-Term Groundwater Contamination Monitoring Strategies.

In this study, we have developed a comprehensive machine learning (ML) framework for long-term groundwater contamination monitoring as the Python package PyLEnM (Python for Long-term Environmental Monitoring). PyLEnM aims to establish the seamless data-to-ML pipeline with various utility functions, such as quality assurance and quality control (QA/QC), coincident/colocated data identification, the automated ingestion and processing of publicly available spatial data layers, and novel data summarization/visualization. The key ML innovations include (1) time series/multianalyte clustering to find the well groups that have similar groundwater dynamics and to inform spatial interpolation and well optimization, (2) the automated model selection and parameter tuning, comparing multiple regression models for spatial interpolation, (3) the proxy-based spatial interpolation method by including spatial data layers or in situ measurable variables as predictors for contaminant concentrations and groundwater levels, and (4) the new well optimization algorithm to identify the most effective subset of wells for maintaining the spatial interpolation ability for long-term monitoring. We demonstrate our methodology using the monitoring data at the Savannah River Site F-Area. Through this open-source PyLEnM package, we aim to improve the transparency of data analytics at contaminated sites, empowering concerned citizens as well as improving public relations.

Corrigendum: Neural Correlates of Freezing of Gait in Parkinson's Disease: An Electrophysiology Mini-Review.

[This corrects the article DOI: 10.3389/fneur.2020.571086.].

Neural Correlates of Freezing of Gait in Parkinson's Disease: An Electrophysiology Mini-Review.

Freezing of gait (FoG) is a disabling symptom characterized as a brief inability to step or by short steps, which occurs when initiating gait or while turning, affecting over half the population with advanced Parkinson's disease (PD). Several non-competing hypotheses have been proposed to explain the pathophysiology and mechanism behind FoG. Yet, due to the complexity of FoG and the lack of a complete understanding of its mechanism, no clear consensus has been reached on the best treatment options. Moreover, most studies that aim to explore neural biomarkers of FoG have been limited to semi-static or imagined paradigms. One of the biggest unmet needs in the field is the identification of reliable biomarkers that can be construed from real walking scenarios to guide better treatments and validate medical and therapeutic interventions. Advances in neural electrophysiology exploration, including EEG and DBS, will allow for pathophysiology research on more real-to-life scenarios for better FoG biomarker identification and validation. The major aim of this review is to highlight the most up-to-date studies that explain the mechanisms underlying FoG through electrophysiology explorations. The latest methodological approaches used in the neurophysiological study of FoG are summarized, and potential future research directions are discussed.

Sensor Location Optimization of Wireless Wearable fNIRS System for Cognitive Workload Monitoring Using a Data-Driven Approach for Improved Wearability.

Functional Near-Infrared Spectroscopy (fNIRS) is a hemodynamic modality in human cognitive workload assessment receiving popularity due to its easier implementation, non-invasiveness, low cost and other benefits from the signal-processing point of view. Wearable wireless fNIRS systems used in research have promisingly shown that fNIRS could be used in cognitive workload assessment in out-of-the-lab scenarios, such as in operators' cognitive workload monitoring. In such a scenario, the wearability of the system is a significant factor affecting user comfort. In this respect, the wearability of the system can be improved if it is possible to minimize an fNIRS system without much compromise of the cognitive workload detection accuracy. In this study, cognitive workload-related hemodynamic changes were acquired using an fNIRS system covering the whole forehead, which is the region of interest in most cognitive workload-monitoring studies. A machine learning approach was applied to explore how the mean accuracy of the cognitive workload classification accuracy varied across various sensing locations on the forehead such as the Left, Mid, Right, Left-Mid, Right-Mid and Whole forehead. The statistical significance analysis result showed that the Mid location could result in significant cognitive workload classification accuracy compared to Whole forehead sensing, with a statistically insignificant difference in the mean accuracy. Thus, the wearable fNIRS system can be improved in terms of wearability by optimizing the sensor location, considering the sensing of the Mid location on the forehead for cognitive workload monitoring.

Asynchronous Prediction of Human Gait Intention in a Pseudo Online Paradigm Using Wavelet Transform.

Prediction of human voluntary gait intention is a very significant task to ensure direct cortical control of real-life assistive technologies for locomotion rehabilitation. Neurophysiological studies provide that human voluntary gait intention is represented by slow DC potentials and power shifts in specific frequency ranges of brain wave, which can be detected 1.5- 2 seconds before the actual onset. The goal of this study was to determine whether it is possible to reliably detect the intention of voluntary gait 'starting' and 'stopping' intention before it takes place. A computational algorithm was designed to implement asynchronous prediction of gait intention in an offline and pseudo-online environment using support vector machine. Six healthy subjects participated in the study and performed self- paced voluntary gait cycles. A combination of advanced wavelet transform algorithms resulted in 88.23± 1.59% accuracy, 85.42± 4.03% sensitivity and 90.24± 2.78% specificity for intention of start detection and 87.04± 1.72% accuracy, 82.69± 4.13% sensitivity and 89.59± 3.04% specificity for intention to stop walking in offline testing. Additionally, the wavelet transform methods accompanied with threshold regulation and majority voting algorithm resulted in a True Positive Rate of 85.5± 5.0% and 81.2± 3.3% for 'start' and 'stop' prediction with 6.8± 0.7 and 9.4± 1.0 False Positives per Minute respectively in pseudo online testing. The average detection latencies were -1002 ± 603 ms and -943 ± 603 ms, respectively, for 'start' and 'stop' prediction. The study provides promising outcomes in terms of TPR, FP/min, and detection latency, which suggests that human voluntary gait intention can be predicted before the onset of movement.

Prediction of gait intention from pre-movement EEG signals: a feasibility study.

BACKGROUND: Prediction of Gait intention from pre-movement Electroencephalography (EEG) signals is a vital step in developing a real-time Brain-computer Interface (BCI) for a proper neuro-rehabilitation system. In that respect, this paper investigates the feasibility of a fully predictive methodology to detect the intention to start and stop a gait cycle by utilizing EEG signals obtained before the event occurrence. METHODS: An eight-channel, custom-made, EEG system with electrodes placed around the sensorimotor cortex was used to acquire EEG data from six healthy subjects and two amputees. A discrete wavelet transform-based method was employed to capture event related information in alpha and beta bands in the time-frequency domain. The Hjorth parameters, namely activity, mobility, and complexity, were extracted as features while a two-sample unpaired Wilcoxon test was used to get rid of redundant features for better classification accuracy. The feature set thus obtained was then used to classify between 'walk vs. stop' and 'rest vs. start' classes using support vector machine (SVM) classifier with RBF kernel in a ten-fold cross-validation scheme. RESULTS: Using a fully predictive intention detection system, 76.41±4.47% accuracy, 72.85±7.48% sensitivity, and 79.93±5.50% specificity were achieved for 'rest vs. start' classification. While for 'walk vs. stop' classification, the obtained mean accuracy, sensitivity, and specificity were 74.12±4.12%, 70.24±6.45%, and 77.78±7.01% respectively. Overall average True Positive Rate achieved by this methodology was 72.06±8.27% with 1.45 False Positives/min. CONCLUSION: Extensive simulations and resulting classification results show that it is possible to achieve statistically similar intention detection accuracy using either only pre-movement EEG features or trans-movement EEG features. The classifier performance shows the potential of the proposed methodology to predict human movement intention exclusively from the pre-movement EEG signal to be applied in real-life prosthetic and neuro-rehabilitation systems.

Movement artefact removal from NIRS signal using multi-channel IMU data.

BACKGROUND: The non-invasive nature of near-infrared spectroscopy (NIRS) makes it a widely accepted method for blood oxygenation measurement in various parts of the human body. One of the main challenges in this method lies in the successful removal of movement artefacts in the detected signal. In this respect, multi-channel inertia measurement unit (IMU) containing accelerometer, gyroscope and magnetometer can be used for better modelling of movement artefact than using accelerometer only, which as a result, movement artefact can be more accurately removed. METHODS: A wearable two-channel continuous wave NIRS system, incorporating an IMU sensor which contain accelerometer, gyroscope and magnetometer in it, was developed to record NIRS signal along with the simultaneous recording of movement artefacts related signal using the IMU. Four healthy subjects volunteered in the recording of the NIRS signals. During the recording from the first two subject, movement artefacts were simulated in one of the NIRS channels by tapping the photodiode sensor nearby. The corresponding IMU data for the simulated movement artefacts were used to estimate the artefacts in the corrupted signal by autoregressive with exogenous input method and subtracted from the corrupted signal to remove the artefacts in the NIRS signal. Signal-to-noise ratio (SNR) improvement was used to evaluate the performance of the movement artefacts removal process. The performance of the movement artefacts estimation and removal were compared using accelerometer only, accelerometer and gyroscope, and accelerometer, gyroscope and magnetometer data from IMU sensor to estimate the artefact in NIRS reading. For the remaining two subjects the NIRS signal was recorded by natural movement artefacts impact and the results of artefacts removal was compared using accelerometer only, accelerometer and gyroscope, and accelerometer, gyroscope and magnetometer data from IMU sensor to estimate the artefact in NIRS reading. RESULTS: The quantitative and qualitative results revealed that the SNR improvement increases with the number of IMU channels used in the artefacts estimation, and there were approximately 5-11 dB increase in SNR when nine channel IMU data were used rather than using only three channel accelerometer data only. The artefact removal from natural movements also demonstrated that the combination of gyroscope and magnetometer sensors with accelerometer provided better estimation and removal of the movement artefacts, which was revealed by the minimal change of the HbO2 and Hb level before, during and after movement artefacts occurred in the NIRS signal. CONCLUSION: The movement artefacts in NIRS can be more accurately estimated and removed by using accelerometer, gyroscope and magnetograph signals from an integrated IMU sensor than using accelerometer signal only.

Smart Data-Driven Optimization of Powered Prosthetic Ankles Using Surface Electromyography.

The advent of powered prosthetic ankles provided more balance and optimal energy expenditure to lower amputee gait. However, these types of systems require an extensive setup where the parameters of the ankle, such as the amount of positive power and the stiffness of the ankle, need to be setup. Currently, calibrations are performed by experts, who base the inputs on subjective observations and experience. In this study, a novel evidence-based tuning method was presented using multi-channel electromyogram data from the residual limb, and a model for muscle activity was built. Tuning using this model requires an exhaustive search over all the possible combinations of parameters, leading to computationally inefficient system. Various data-driven optimization methods were investigated and a modified Nelder⁻Mead algorithm using a Latin Hypercube Sampling method was introduced to tune the powered prosthetic. The results of the modified Nelder⁻Mead optimization were compared to the Exhaustive search, Genetic Algorithm, and conventional Nelder⁻Mead method, and the results showed the feasibility of using the presented method, to objectively calibrate the parameters in a time-efficient way using biological evidence.