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1.
Appl Neuropsychol Child ; : 1-11, 2024 Apr 11.
Artículo en Inglés | MEDLINE | ID: mdl-38604218

RESUMEN

This pilot study investigated the long-term impact of a surgery-only treatment (no exposure to other treatments, such as chemotherapy and radiation) for pediatric cerebellar low-grade gliomas on executive function, anxiety, and fear of pain (FOP) beliefs. Twelve patients who underwent surgical glioma resection during childhood (surgery age was 4-16 years, study visit age was 10-28 years), and 12 pain-free controls matched for age, sex, race, and handedness were tested. The spatial extent of resection was precisely mapped using magnetic resonance imaging (MRI). Executive function, anxiety, and FOP were assessed using validated self-report age-appropriate questionnaires for children and adults. Structured clinical interviews at a post-surgery follow-up visit were completed (average: 89 months, range: 20-99). No significant differences in FOP (FOPQ-C t[14 = 1.81, p = 0.09; FOPQ-III t[4] = 0.29, p = 0.79), executive function scores (BRIEF t[20] = 0.30, p = 0.28), or anxiety scores (MASC t[16] = 0.19, p = 0.85; MAQ t[4] = 1.80, p = 0.15) were found in pediatric or adult patients compared to pain-free controls. Clinical interviews mainly categorized pediatric patients as not anxious. One participant reported mild/subclinical anxiety, and one had moderate clinical anxiety. Neither psychologists nor patients endorsed impairments to executive functioning, anxiety, or FOP. Our pilot results suggest that pediatric cerebellar tumor survivors treated with surgery-only have favorable long-term functioning related to these themes. While these results are promising, they will need to be replicated in a larger patient sample.

2.
J Obstet Gynecol Neonatal Nurs ; 49(6): 581-592, 2020 11.
Artículo en Inglés | MEDLINE | ID: mdl-32822649

RESUMEN

OBJECTIVE: To develop a conceptual theory to describe how financial strain affects women with young children to inform clinical care and research. DESIGN: Qualitative, grounded theory. SETTING: Participants were recruited from the waiting area of a pediatric clinic and an office of the Special Supplemental Nutrition Program for Women, Infants, and Children embedded within the largest safety-net academic medical center in New England. Participants were interviewed privately at the medical center or in the community. PARTICIPANTS: Twenty-six English-speaking women, mostly single and African American/Black, with at least one child 5 years old or younger, were sampled until thematic saturation was met. METHODS: We used grounded theory methodology to conduct in-depth, semistructured interviews with participants who indicated that they experienced financial strain. We analyzed the interview data using constant comparative analysis, revised the interview guide based on emerging themes, and developed a theoretical model. RESULTS: Five interrelated themes emerged and were developed into a theoretical model: Financial Strain Has Specific Characteristics and Common Triggers, Financial Strain Is Exacerbated by Inadequate Assistance and Results in Tradeoffs, Financial Strain Forces Parenting Modifications, Women Experience Self-Blame, and Women Experience Mental Health Effects. CONCLUSION: For women with young children, financial strain results in forced tradeoffs, compromised parenting practices, and self-blame, which contribute to significant mental health problems. These findings can inform woman-centered clinical practice and advocacy interventions. Women's health care providers should identify families experiencing financial strain, provide referrals to financial services, and join advocacy efforts to advance social policies that address the structural causes of poverty, such as increased minimum wage and paid family leave.


Asunto(s)
Estrés Financiero/complicaciones , Trastornos Mentales/diagnóstico , Responsabilidad Parental/psicología , Adulto , Preescolar , Femenino , Estrés Financiero/psicología , Teoría Fundamentada , Humanos , Lactante , Entrevistas como Asunto/métodos , Trastornos Mentales/epidemiología , New England , Responsabilidad Parental/tendencias , Investigación Cualitativa
3.
Neuroimage Clin ; 24: 102096, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31795037

RESUMEN

Numerous pathologies can contribute to photophobia. When considering light transduction alone, photophobia may be triggered through melanopsin pathways (non-image forming), rod and cone pathways (image-forming), or some combination of the two. We evaluated a 39 year old female patient with longstanding idiopathic photophobia that was exacerbated by blue light, and tested her by presenting visual stimuli in an event-related fMRI experiment. Analysis showed significantly greater activation in bilateral pulvinar nuclei, associated with the melanopsin intrinsically photosensitive retinal ganglion cell (ipRGC) visual pathway, and their activation is consistent with the patient's report that blue light differentially evoked photophobia. This appears to be the first demonstration of functional activation of the ipRGC pathway during photophobia in a patient.


Asunto(s)
Dolor Ocular/diagnóstico por imagen , Luz , Fotofobia/diagnóstico por imagen , Pulvinar/diagnóstico por imagen , Adulto , Tronco Encefálico/diagnóstico por imagen , Tronco Encefálico/fisiopatología , Cerebelo/diagnóstico por imagen , Cerebelo/fisiopatología , Dolor Ocular/fisiopatología , Femenino , Neuroimagen Funcional , Humanos , Imagen por Resonancia Magnética , Fotofobia/metabolismo , Fotofobia/fisiopatología , Corteza Prefrontal/diagnóstico por imagen , Corteza Prefrontal/fisiopatología , Pulvinar/fisiopatología , Células Ganglionares de la Retina , Opsinas de Bastones/metabolismo , Lóbulo Temporal/diagnóstico por imagen , Lóbulo Temporal/fisiopatología , Vías Visuales/diagnóstico por imagen , Vías Visuales/fisiopatología
4.
Hum Brain Mapp ; 40(15): 4381-4396, 2019 10 15.
Artículo en Inglés | MEDLINE | ID: mdl-31298464

RESUMEN

The evaluation of brain changes to a specific pain condition in pediatric and adult patients allows for insights into potential mechanisms of pain chronicity and possibly long-term brain changes. Here we focused on the primary somatosensory system (SS) involved in pain processing, namely the ventroposterolateral thalamus (VPL) and the primary somatosensory cortex (SI). We evaluated, using MRI, three specific processes: (a) somatotopy of changes in the SS for different pain origins (viz., foot vs. arm); (b) differences in acute (ankle sprain versus complex regional pain syndrome-CRPS); and (c) differences of the effects of CRPS on SS in pediatric versus adult patients. In all cases, age- and sex-matched individuals were used as controls. Our results suggest a shift in concurrent gray matter density (GMD) and resting functional connectivity strengths (rFC) across pediatric and adult CRPS with (a) differential patterns of GMD (VPL) and rFC (SI) on SS in pediatric vs. adult patterns that are consistent with upper and lower limb somatotopical organization; and (b) widespread GMD alterations in pediatric CRPS from sensory, emotional and descending modulatory processes to more confined sensory-emotional changes in adult CRPS and rFC patterns from sensory-sensory alterations in pediatric populations to a sensory-emotional change in adult populations. These results support the idea that pediatric and adult CRPS are differentially represented and may reflect underlying differences in pain chronification across age groups that may contribute to the well-known differences between child and adult pain vulnerability and resilience.


Asunto(s)
Dolor Crónico/fisiopatología , Conectoma/métodos , Red Nerviosa/fisiología , Distrofia Simpática Refleja/fisiopatología , Corteza Somatosensorial/fisiopatología , Adolescente , Adulto , Factores de Edad , Anciano , Traumatismos del Tobillo/patología , Traumatismos del Tobillo/fisiopatología , Estudios de Casos y Controles , Niño , Susceptibilidad a Enfermedades , Sustancia Gris/patología , Sustancia Gris/fisiopatología , Humanos , Imagen por Resonancia Magnética , Persona de Mediana Edad , Modelos Neurológicos , Dolor Musculoesquelético/patología , Dolor Musculoesquelético/fisiopatología , Red Nerviosa/anatomía & histología , Especificidad de Órganos , Dimensión del Dolor , Distrofia Simpática Refleja/diagnóstico por imagen , Distrofia Simpática Refleja/patología , Corteza Somatosensorial/diagnóstico por imagen , Corteza Somatosensorial/patología , Esguinces y Distensiones/fisiopatología , Tálamo/diagnóstico por imagen , Tálamo/patología , Tálamo/fisiopatología , Adulto Joven
5.
Ann Clin Transl Neurol ; 6(2): 344-354, 2019 02.
Artículo en Inglés | MEDLINE | ID: mdl-30847366

RESUMEN

Objectives: Damage to the posterior cerebellum can cause affective deficits in patients. In adults, cerebellar infarcts result in thermal hyperalgesia and affect descending modulation of pain. This study evaluated the effect of resection of low-grade cerebellar tumors on pain processing in human children. Methods: Twelve pediatric patients treated with surgery only for low-grade gliomas (8 females, 4 males; mean age = 13.8 ± 5.6) and twelve matched controls (8 females, 4 males; mean age = 13.8 ± 5.7) were evaluated using quantitative sensory testing and fMRI. Five patients had tumors localized to posterior cerebellar hemispheres, henceforth identified as Crus Patients. Results: Crus Patients had significantly lower pain tolerance to a cold pressor test than controls. No significant differences were detected between subject groups for heat and cold detection thresholds (HDT, CDT), and heat and cold pain thresholds (HPT, CPT). Crus Patients also showed significantly decreased fMRI responses to painful heat in anterior insula, which has been associated with pain affect. Interpretation: Damage to posterior cerebellar hemispheres disrupted affective pain processing and endogenous pain modulation, resulting in decreased pain tolerance to suprathreshold noxious stimuli. This suggests that surgical resection of this region in children may increase the risk of developing pain disorders.


Asunto(s)
Neoplasias Cerebelosas/fisiopatología , Neoplasias Cerebelosas/cirugía , Hiperalgesia/cirugía , Dolor/fisiopatología , Adolescente , Cerebelo/cirugía , Niño , Femenino , Humanos , Imagen por Resonancia Magnética/métodos , Masculino , Dimensión del Dolor , Umbral del Dolor/fisiología , Adulto Joven
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