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Background: The improvement of absent or partial response in the medical treatment of erectile dysfunction (ED) has led to the development of minimally invasive new treatment modalities in the field of regenerative medicine. Methods: A literature review on stem cell therapy for the treatment of ED was performed. We searched for the terms "erectile dysfunction" and "stem cell therapy" in PubMed and Clinicaltrials.gov. Literature searching was conducted in English and included articles from 2010 to 2022. Results: New treatment modalities for ED involving stem cell therapy are not only conceived with a curative intent but also aim to avoid unnecessary adverse effects. Several sources of stem cells have been described, each with unique characteristics and potential applications, and different delivery methods have been explored. A limited number of interventional studies over the past recent years have provided evidence of a safety profile in their use and promising results for the treatment of ED, although there are not enough studies to generate an appropriate protocol, dose or cell lineage, or to determine a mechanism of action. Conclusions: Stem cell therapy is a novel treatment for ED with potential future applications. However, most urological societies agree that further research is required to conclusively prove its potential benefit.
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UNLABELLED: Patients with Benign Prostatic Obstruction (BPO) and Myasthenia Gravis (MG) treated with Transurethral Resection of the prostate (TURP) show a high incidence of urinary incontinence due to unnoticed damage to muscle fibres of the external sphincter. Photoselective laser vaporization could be an alternative treatment based on the hypothesis that using Laser as energy source in the treatment of BPH prevents sphincter damage because the energy is not transmitted outside the fiber tip. METHODS: We report the case of a man diagnosed of MG and symptomatic BPO treated satisfactorily with photoselective laser vaporization (GreenLight-XPS). RESULTS: Patient did not experienced postoperative secondary incontinence. CONCLUSIONS: Laser photoselective vaporization (GreenLight-XPS) could be the standard treatment for men with MG and BPO, whose prostate volume is less than 60 cc who are candidates for surgical treatment. Despite the extremely low incidence of these cases, further investigations are needed to confirm this affirmation.
Asunto(s)
Terapia por Láser , Miastenia Gravis/complicaciones , Hiperplasia Prostática/complicaciones , Hiperplasia Prostática/cirugía , Obstrucción Uretral/etiología , Obstrucción Uretral/cirugía , Anciano , Humanos , Masculino , Incontinencia UrinariaRESUMEN
OBJETIVOS: Los pacientes con miastenia gravis (MG) diagnosticados de sintomatología del tracto urinario inferior (STUI) secundaria a hiperplasia benigna de próstata (HBP), presentan una elevada incidencia de incontinencia urinaria al ser sometidos a resección transuretral de próstata (RTUp), secundaria a la lesión inadvertida de las fibras musculares del esfínter externo. La fotovaporización prostática con Láser podría ser una alternativa de tratamiento, ya que podría evitar el daño inadvertido del esfínter debido a que la energía no se transmite más allá de la punta de la fibra. MÉTODOS: Presentamos el caso de un varón con antecedente de MG y HBP sintomática tratado de forma satisfactoria mediante fotovaporiazación selectiva con Láser verde (GreenLight-XPS). RESULTADOS: El paciente no presentó incontinencia urinaria tras la cirugía. CONCLUSIONES: La fotovaporización prostática con Láser verde (GreenLight-XPS) podría ser el tratamiento estándar de aquellos varones con MG y HBP candidatos a tratamiento quirúrgico, con volumen prostático menor de 60 cc. A pesar de la baja incidencia de estos pacientes, futuros casos son necesarios para corroborar esta afirmación
Patients with Benign Prostatic Obstruction (BPO) and Myasthenia Gravis (MG) treated with Transurethral Resection of the prostate (TURP) show a high incidence of urinary incontinence due to unnoticed damage to muscle fibres of the external sphincter. Photoselective laser vaporization could be an alternative treatment based on the hypothesis that using Laser as energy source in the treatment of BPH prevents sphincter damage because the energy is not transmitted outside the fiber tip. METHODS: We report the case of a man diagnosed of MG and symptomatic BPO treated satisfactorily with photoselective laser vaporization (GreenLight-XPS). Results Patient did not experienced postoperative secondary incontinence. CONCLUSION: Laser photoselective vaporization (GreenLight-XPS) could be the standard treatment for men with MG and BPO, whose prostate volume is less than 60 cc who are candidates for surgical treatment. Despite the extremely low incidence of these cases, further investigations are needed to confirm this affirmation
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Anciano , Humanos , Masculino , Resección Transuretral de la Próstata/tendencias , Resección Transuretral de la Próstata , Miastenia Gravis/terapia , /tendencias , Rayos LáserRESUMEN
OBJECTIVE: To report two cases of prostatic abscess of difficult management and review the literature on diagnosis and management of this entity. METHODS /RESULTS: We describe two patients with prostatic abscess. The first one, a 73-year-old diabetic male, was treated using a more passive approach with percutaneous transrectal drainage; after a slow response, the patient passed away due to sepsis. The second case was a 59-year-old male who experienced a negative clinical response to antibiotic treatment. While under antibiotic ambulatory care the patient was treated with a transurethral resection of the prostate, which yielded a successful outcome. CONCLUSION: Prostatic abscess is a rare entity that affects individuals experiencing weakness and can be a serious condition. Measures taken to arrive at a resolution must be rapid and appropriate.
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Absceso/diagnóstico , Absceso/terapia , Enfermedades de la Próstata/diagnóstico , Enfermedades de la Próstata/terapia , Absceso/tratamiento farmacológico , Anciano , Antibacterianos/efectos adversos , Antibacterianos/uso terapéutico , Diabetes Mellitus Tipo 2/complicaciones , Drenaje , Resultado Fatal , Gentamicinas/efectos adversos , Gentamicinas/uso terapéutico , Hepatitis B Crónica/complicaciones , Humanos , Masculino , Metronidazol/efectos adversos , Metronidazol/uso terapéutico , Persona de Mediana Edad , Ofloxacino/efectos adversos , Ofloxacino/uso terapéutico , Enfermedades de la Próstata/tratamiento farmacológico , Insuficiencia Renal Crónica/complicaciones , Sepsis/etiología , Tomografía Computarizada por Rayos X , Resección Transuretral de la PróstataRESUMEN
OBJETIVO: Presentar dos casos clínicos de absceso prostático de difícil manejo y revisar el diagnóstico y tratamiento de esta entidad.MÉTODOS/RESULTADOS: Descripción de dos pacientes con absceso prostático. El primer caso es un varón diabético de 73 años a quien se le instaura un manejo conservador con drenaje percutáneo transrectal y quien tras una evolución tórpida fallece de una sepsis urológica. El segundo caso es un varón de 59 años con mala evolución clínica tras tratamiento antibiótico ambulatorio realizándose una resección transuretral de próstata con resultado satisfactorio.CONCLUSIÓN: El absceso prostático es una entidad rara. Afecta principalmente a personas debilitadas lo que le confiere un carácter grave. Las medidas encaminadas a su resolución deben ser rápidas y oportunas(AU)
OBJECTIVE: To report two cases of prostatic abscess of difficult management and review the literature on diagnosis and management of this entity.METHODS /RESULTS: We describe two patients with prostatic abscess. The first one, a 73-year-old diabetic male, was treated using a more passive approach with percutaneous transrectal drainage; after a slow response, the patient passed away due to sepsis. The second case was a 59-year-old male who experienced a negative clinical response to antibiotic treatment. While under antibiotic ambulatory care the patient was treated with a transurethral resection of the prostate, which yielded a successful outcome.CONCLUSION: Prostatic abscess is a rare entity that affects individuals experiencing weakness and can be a serious condition. Measures taken to arrive at a resolution must be rapid and appropriate(AU)