Asunto(s)
Neoplasias Gastrointestinales/patología , Leiomioma/patología , Leiomiosarcoma/patología , Desmina/análisis , Neoplasias Gastrointestinales/análisis , Neoplasias Gastrointestinales/ultraestructura , Proteína Ácida Fibrilar de la Glía/análisis , Leiomioma/análisis , Leiomioma/ultraestructura , Leiomiosarcoma/análisis , Leiomiosarcoma/ultraestructura , Proteínas S100/análisisAsunto(s)
Tiroglobulina/metabolismo , Enfermedades de la Tiroides/metabolismo , Glándula Tiroides/metabolismo , Tiroxina/metabolismo , Adenocarcinoma/metabolismo , Adenocarcinoma/patología , Humanos , Técnicas para Inmunoenzimas , Neoplasias de la Tiroides/metabolismo , Neoplasias de la Tiroides/patologíaRESUMEN
The gastrin-producing G-cells of the antropyloric mucosa are affected by a variety of disorders. By immunoperoxidase methods, employing a specific anti-gastrin I and II antibody, we demonstrated G cells in antropyloric biopsies of 15 patients with chronic gastritis, 6 of them with gastric ulcer and 1 with duodenal ulcer disease. As controls we studied 5 biopsies of histologically normal antropyloric mucosa. We correlated the numbers of G cells per gland with the histological, clinical and endoscopic findings. Normal antropyloric mucosa contained a mean of 2.11 G cells per gland. Patients with chronic gastritis had decreased numbers of G cells (mean 0.75) The difference was statistically significant. The cases with chronic gastritis and intestinal metaplasia had lower numbers of G cells (mean 0.38). The case with duodenal ulcer had a number of G-cells similar of normal cases (1.57). This finding give a morphologic basis for the low gastrin serum levels usually present in these entities.
Asunto(s)
Mucosa Gástrica/patología , Gastrinas/metabolismo , Gastritis/patología , Adulto , Mucosa Gástrica/citología , Gastrinas/sangre , Gastritis/metabolismo , Humanos , Persona de Mediana EdadRESUMEN
En un grupo de 15 pacientes con gastritis cronica antral se observo una disminucion estadisticamente significativa de celulas G (productoras de gastrina) por seccion glandular en comparacion con los controles normales. Esta disminucion fue todavia mas acentuada en aquellos que presentaban metaplasia intestinal o ulcera peptica activa. La disminucion de celulas G seria el sustrato morfologico de los bajos niveles sericos de gastrina que presentan estos pacientes en respuesta a una ingesta proteica
Asunto(s)
Gastrinas , Gastritis , Técnicas para InmunoenzimasRESUMEN
En un grupo de 15 pacientes con gastritis cronica antral se observo una disminucion estadisticamente significativa de celulas G (productoras de gastrina) por seccion glandular en comparacion con los controles normales. Esta disminucion fue todavia mas acentuada en aquellos que presentaban metaplasia intestinal o ulcera peptica activa. La disminucion de celulas G seria el sustrato morfologico de los bajos niveles sericos de gastrina que presentan estos pacientes en respuesta a una ingesta proteica
Asunto(s)
Gastrinas , Gastritis , Técnicas para InmunoenzimasRESUMEN
The gastrin-producing G-cells of the antropyloric mucosa are affected by a variety of disorders. By immunoperoxidase methods, employing a specific anti-gastrin I and II antibody, we demonstrated G cells in antropyloric biopsies of 15 patients with chronic gastritis, 6 of them with gastric ulcer and 1 with duodenal ulcer disease. As controls we studied 5 biopsies of histologically normal antropyloric mucosa. We correlated the numbers of G cells per gland with the histological, clinical and endoscopic findings. Normal antropyloric mucosa contained a mean of 2.11 G cells per gland. Patients with chronic gastritis had decreased numbers of G cells (mean 0.75) The difference was statistically significant. The cases with chronic gastritis and intestinal metaplasia had lower numbers of G cells (mean 0.38). The case with duodenal ulcer had a number of G-cells similar of normal cases (1.57). This finding give a morphologic basis for the low gastrin serum levels usually present in these entities.