Testing Models of Associations Between Depression and Parenting Self-efficacy in Mothers: A Meta-analytic Review.

Numerous cross-sectional studies confirm the long-theorized association between mothers' depression and lower parenting self-efficacy (PSE) beliefs. However, cross-sectional studies leave unanswered the direction of this association: Does depression predict PSE? Does PSE predict depression? Are both true? Does the strength of the association between depression and PSE, regardless of the direction, generalize across participant characteristics and study design features? How stable is PSE over time? And how effective are interventions at enhancing PSE? To answer these questions, we conducted a meta-analytic review of longitudinal studies. With 35 eligible studies (22,698 participants), we found support for both models: there was a significant pooled effect of both depression on PSE and of PSE on depression, with nearly identical effect sizes (d = - 0.21 and - 0.22, respectively). The association was stronger in samples with mothers' younger average age and studies that measured PSE among mothers relative to during pregnancy. We found a medium degree of stability in the index of PSE, d = 0.60. Finally, the estimated pooled effect size between being in an intervention group versus control group and PSE was 0.505. Overall, we found support for (1) bidirectional associations between depression and PSE in mothers, (2) the stability of PSE over time, and (3) the strength of the relationship between PSE and depression with intervention. These results suggest the importance of continuing to develop, test, and disseminate interventions to enhance PSE. We interpret these findings in the context of both depression and low PSE having serious consequences for child outcomes and maladaptive parenting.

Making Family-Centered Care for Adults in the ICU a Reality.

Despite the value of family-centered care (FCC) in intensive care units (ICUs), this approach is rarely a reality in this context. This article aims to increase the likelihood that ICU-based care incorporates best practices for FCC. Consistent with this goal, this article begins by overviewing FCC and its merits and challenges in ICUs. It then offers a systemic framework for conceptualizing FCC in this challenging environment, as such a model can help guide the implementation of this invaluable approach. This systemic framework combined with previous guidelines for FCC in the ICU are used to inform the series of recommended best practices for FCC in the ICU that balance the needs and realities of patients, families, and the interprofessional healthcare team. These best practices reflect an integration of the existing literature and previously published guidelines as well as our experiences as healthcare providers, family members, and patients. We encourage healthcare leaders and interprofessional ICU healthcare teams to adopt these best practices and modify them for the specific healthcare needs of the patients they serve and their families.

Correction to: Parenting as a Mediator of Associations between Depression in Mothers and Children's Functioning: A Systematic Review and Meta-Analysis.

The original version of the article requires a correction to one of the sentences. Under the section 'Limitations', the last sentence 'Findings of no support for mediation was also deemed important as, for example, our findings suggest..' should read as below. Also important were where we found no support for moderation of the mediation model; for example, our findings suggest that parenting as a mediator of associations between depression and child functioning is concerning regardless of the ages of the children, for both sons and daughters, and for a broad range of aspects of children's functioning.

Parenting as a Mediator of Associations between Depression in Mothers and Children's Functioning: A Systematic Review and Meta-Analysis.

This paper responds to the need to understand mechanisms in the pathways of risk from depression in mothers to their children's functioning. We systematically reviewed evidence in support of one often-proposed mediational model: that problematic parenting at least partially explains associations between mothers' depression and children's adverse functioning. We further aimed to understand the conceptual and method-based moderators. Eligible studies had to be published in English in a peer-reviewed journal, include data on mothers' depression and parenting and child functioning, and have a study design whereby measurement of depression in mothers preceded the measurement of parenting, which preceded the measurement of child outcome. Overall, across the 40 papers (37 "studies") that met our inclusion criteria, we found a significant, albeit small effect (r = .016), for the mediational model as a whole. This effect size was robust to context (poverty and ethnicity), children's characteristics of age and gender, and parenting quality (positive or negative). The model was significant for multiple domains of child functioning, although effect sizes varied across domains. We also found support, with small effect sizes, for all three pathways in the mediational model and some support for moderation of those pathways. Overall, the findings provide empirical support for parenting (both positive and negative) as a mediator of associations between mothers' depression and a broad range of child functioning and suggest that interventions should target samples that represent the population in terms of poverty and ethnicity and children's gender, with priority going to interventions targeting the youngest children.

Validating parent and child forms of the Parent Perception Inventory.

Understanding parenting from both parent and child perspectives is critical to child clinical and developmental research. Similarities and differences between parents' and children's reports can be highly informative, but only if they derive from psychometrically sound measures that assess the same parenting constructs. We examined the psychometric properties of the child and parent forms of the Parenting Perception Inventory (Bruce et al., 2006), which measures perceptions of two higher-order dimensions: positive, warm, supportive parenting; and negative, harsh, critical parenting. Data from a four-wave, longitudinal study of community children and adolescents (n = 876, Mage = 9.5 at the beginning), and data from a study of children (n = 131, Mage = 9.35) of depressed and nondepressed mothers provided psychometric support for both measures. Factor analyses revealed the existence of two factors in both the child and parent forms, and showed strong congruence across the two forms. Other analyses examined longitudinal structure, item difficulty, item discriminations, and scale coverage of the child form. Parents' and children's perceptions of parenting were related to children's affect, emotionality, and depressive symptoms. Parents' perceptions of parenting were related to parents' depressive symptoms and to parenting self-efficacy. (PsycINFO Database Record

Electrochemical simulation of metabolic reactions of the secondary fungal metabolites alternariol and alternariol methyl ether.

Mycotoxins are secondary plant metabolites that have been found to cause severe diseases in humans and livestock. Exposure can take place on a daily basis since mycotoxins can be found not only in food, animal food, and dietary supplements but also in materials used in buildings. For this work, the Alternaria toxins alternariol (AOH) and alternariol methyl ether (AME) are chosen as representatives for this relevant compound class and are investigated regarding their oxidative phase I metabolism using a combination of electrochemical (EC) oxidation and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). This previously established method has been proven to be a valuable tool for the electrochemical simulation of certain phase I metabolic reactions. A comparison of the electrochemically generated products with those formed during microsomal incubation demonstrates the potential of the method for the successful prediction of the main phase I metabolic reactions of mycotoxins. It can thus find use as a supportive method in the elucidation of the metabolic pathways of various mycotoxins.

Combination of electrochemistry and nuclear magnetic resonance spectroscopy for metabolism studies.

During the development of new materials demonstrating biological activity, prediction and identification of reactive intermediates generated in the course of drug metabolism in the human liver is of great importance. We present a rapid and purely instrumental method for the structure elucidation of possible phase I metabolites. With electrochemical (EC) conversion adopting the oxidative function of liver-inherent enzymes and nuclear magnetic resonance (NMR) spectroscopy enabling structure elucidation, comprehensive knowledge on potential metabolites can be gained. Paracetamol (APAP) has been known to induce hepatotoxicity when exceeding therapeutic doses and was therefore selected as the test compound. The reactive metabolite N-acetyl-p-benzoquinone imine has long been proven to be responsible for the toxic side effects of APAP and can easily be generated by EC. EC coupled online to NMR is a straightforward technique for structure elucidation of reactive drug intermediates at an early stage in drug discovery.

Identification and quantification of potential metabolites of Gd-based contrast agents by electrochemistry/separations/mass spectrometry.

Oxidative and potentially metabolic pathways of the five most frequently used contrast agents for magnetic resonance imaging (MRI) based on gadolinium (Gd) are examined. The oxidation of gadopentetate (Gd-DTPA) was studied with a focus on electrochemical oxidation coupled to analytical separation methods and mass spectrometric detection. Mass voltammograms generated with online electrochemistry/electrospray ionization mass spectrometry (EC/ESI-MS) gave a first overview of oxidation products. Two potential metabolites could be detected, with the major metabolite originating from an N-dealkylation (M1). Four other Gd complexes used as MRI contrast agents showed similar reactions in the EC/ESI-MS set-up. To obtain more information about the properties and the quantity of the generated products, a wide range of separation and detection techniques was applied in further experiments. Gd-DTPA and its N-dealkylation product were successfully separated by capillary electrophoresis (CE) and detected by ESI-MS and inductively coupled plasma (ICP)-MS, respectively. CE experiments indicated that the second oxidation product (M2) detected in the mass voltammogram is unstable and decomposes to M1. Employing EC/CE/ICP-MS, the quantification of the metabolites could be achieved. Under the employed conditions, 8.8% of Gd-DTPA was oxidized. Online experiments with high performance liquid chromatography (HPLC) coupled to ESI-MS confirmed the decomposition of M2. Time-resolved measurements showed a decrease of M2 and a simultaneous increase in M1 within only a few minutes, confirming the conclusion that M2 degrades to M1, while EC/LC/ICP-MS measurements provided quantitative evidence as well. The EC/MS simulation shows that a metabolic transformation should not be disregarded in further research regarding the trigger of nephrogenic systemic fibrosis (NSF), a disease exclusively observed for several hundred dialysis patients after delivery of Gd-based MRI contrast agents with linear structure. Furthermore, the used methods may allow the prediction of options for the oxidative removal of these contrast agents from wastewaters.

Electrochemistry/liquid chromatography/mass spectrometry as a tool in metabolism studies.

Electrochemistry/liquid chromatography/mass spectrometry is a powerful complementary tool for the simulation of the oxidative metabolism of drugs and other xenobiotics.