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1.
Prog Brain Res ; 137: 443-52, 2002.
Artículo en Inglés | MEDLINE | ID: mdl-12440386

RESUMEN

We have investigated the specificity of reinnervation and terminal arborization of injured retinal ganglion cell (RGC) axons in the brainstem with the object of studying in a simple situation the degree to which regenerating axons are able to replicate the characteristic patterns of terminal arborization and restore normal function. We have focussed here on the pathway that is responsible for the pupillary light reflex, which is mediated through the olivary pretectal nucleus (OPN). In adult rats, the left optic nerve was transected and a segment of peripheral nerve (PN) graft was used to bridge between the retina and different regions of the ipsilateral brainstem, including the superior colliculus. After 4-13 months, regenerated RGC axons were examined in coronal sections stained for cholera toxin B subunit. RGC axons were found extending into the ipsilateral brainstem for distances of up to 6 mm. Within the pretectum, axons innervated the OPN and the nucleus of the optic tract preferentially, and formed distinctive terminal arbors within each. Within the SC axons extended laterally into the visual layers and formed a different type of arborization. On testing the pupillary light reflex, it was found in best cases to show response amplitudes which were comparable to those recorded from control intact animals. However, unlike normals, the response amplitude tended to diminish with repeated stimulation and also appeared to deteriorate with age, although responses could still be detected in some cases as long as 15 months after grafting. These results indicate that regenerating axons can selectively reinnervate denervated nuclei, where they form typical terminal arborizations, and provide the substrates for restoring functional circuitry.


Asunto(s)
Axones/fisiología , Regeneración Nerviosa/fisiología , Nervios Periféricos/trasplante , Células Ganglionares de la Retina/fisiología , Células Ganglionares de la Retina/trasplante , Animales , Tronco Encefálico/fisiología , Masculino , Ratas , Ratas Endogámicas , Ratas Sprague-Dawley , Reflejo Pupilar
2.
J Gen Psychol ; 128(4): 385-99, 2001 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-11892887

RESUMEN

Using the Simple Adaptation technique (SA) and the Ipsilateral Comparison Paradigm (ICP), the authors studied monaural loudness adaptation to a middle-intensity [60 dB(A)] tone at signal frequencies of 250, 1000, and 4000 Hz in the left and right ears. Adaptation effects were absent when the SA procedure was used. However, they were observed uniformly across all frequency values with the ICP, a result that challenges the assertion in the literature, on the basis of SA measures, that loudness adaptation for middle-intensity signals occurs only at frequencies above 4000 Hz. The ICP features periodic intensity modulations (+/-10 dB relative to the base signal) to accommodate listeners' needs for referents by which they can gauge subtle changes in the loudness of the adapting tone, a key component that is missing in the SA method. Adaptation effects in this investigation were similar in both ears, supporting the equal susceptibility assumption common in loudness adaptation studies.


Asunto(s)
Atención , Dominancia Cerebral , Percepción Sonora , Discriminación de la Altura Tonal , Adolescente , Adulto , Femenino , Humanos , Masculino , Psicoacústica , Localización de Sonidos
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