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1.
PLoS One ; 10(8): e0136316, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-26312485

RESUMEN

St. Louis encephalitis virus (SLEV) is a re-emerging arbovirus in South America. In 2005, an encephalitis outbreak caused by SLEV was reported in Argentina. The reason for the outbreak remains unknown, but may have been related to virological factors, changes in vectors populations, avian amplifying hosts, and/or environmental conditions. The main goal of this study was to characterize the complete genome of epidemic and non-epidemic SLEV strains from Argentina. Seventeen amino acid changes were detected; ten were non-conservative and located in proteins E, NS1, NS3 and NS5. Phylogenetic analysis showed two major clades based on geography: the North America and northern Central America (NAnCA) clade and the South America and southern Central America (SAsCA) clade. Interestingly, the presence of SAsCA genotype V SLEV strains in the NAnCA clade was reported in California, Florida and Texas, overlapping with known bird migration flyways. This work represents the first step in understanding the molecular mechanisms underlying virulence and biological variation among SLEV strains.


Asunto(s)
Enfermedades Transmisibles Emergentes/genética , Virus de la Encefalitis de San Luis , Encefalitis de San Luis/genética , Genoma Viral , Filogenia , Proteínas Virales/genética , Animales , Argentina , Chlorocebus aethiops , Enfermedades Transmisibles Emergentes/epidemiología , Virus de la Encefalitis de San Luis/genética , Virus de la Encefalitis de San Luis/patogenicidad , Encefalitis de San Luis/epidemiología , Genotipo , Humanos , Estados Unidos/epidemiología , Células Vero
2.
PLoS Negl Trop Dis ; 6(11): e1875, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-23133685

RESUMEN

Venezuelan equine encephalitis virus (VEEV) has been the causative agent for sporadic epidemics and equine epizootics throughout the Americas since the 1930s. In 1969, an outbreak of Venezuelan equine encephalitis (VEE) spread rapidly from Guatemala and through the Gulf Coast region of Mexico, reaching Texas in 1971. Since this outbreak, there have been very few studies to determine the northward extent of endemic VEEV in this region. This study reports the findings of serologic surveillance in the Gulf Coast region of Mexico from 2003-2010. Phylogenetic analysis was also performed on viral isolates from this region to determine whether there have been substantial genetic changes in VEEV since the 1960s. Based on the findings of this study, the Gulf Coast lineage of subtype IE VEEV continues to actively circulate in this region of Mexico and appears to be responsible for infection of humans and animals throughout this region, including the northern State of Tamaulipas, which borders Texas.


Asunto(s)
Virus de la Encefalitis Equina Venezolana/aislamiento & purificación , Encefalomielitis Equina Venezolana/epidemiología , Enfermedades Endémicas , Adolescente , Adulto , Anciano , Niño , Preescolar , Análisis por Conglomerados , Femenino , Humanos , Lactante , Recién Nacido , Masculino , México/epidemiología , Persona de Mediana Edad , Epidemiología Molecular , Datos de Secuencia Molecular , Filogenia , ARN Viral/genética , Análisis de Secuencia de ADN , Estudios Seroepidemiológicos , Adulto Joven
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