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1.
Ann Indian Acad Neurol ; 19(4): 478-481, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-27994357

RESUMEN

BACKGROUND: In India, the correlates of leukoaraiosis (LA) have not been widely reported. This study was designed to investigate the factors which correlate with LA. MATERIALS AND METHODS: We included patients with LA who consented for the study and graded their severity on the basis of Fazekas scale. We excluded patients with LA who did not consent/cooperate for the study as also patients with other white matter changes which mimic LA. RESULTS: LA is a common and under-rated cause of disability. Presentations include cognitive decline, gait disturbance, dysarthria, bladder/bowel sphincter disturbances, and increased risk of stroke. The comorbidities include hyperhomocysteinemia, hypertension, dyslipidemia, tobacco use, ischemic heart disease, previous stroke, atrial fibrillation, chronic renal failure, and bariatric surgery.

2.
Indian J Pediatr ; 82(5): 404-9, 2015 May.
Artículo en Inglés | MEDLINE | ID: mdl-24777622

RESUMEN

OBJECTIVE: To ascertain the impact of pituitary size as judged by Magnetic Resonance Imaging (MRI), on response to Growth Hormone (GH) therapy in GH deficient children. METHODS: Thirty nine children (9.1 ± 2.7 y, 22 boys) with non-acquired GH deficiency (21 Isolated GH deficiency and 18 Combined pituitary hormone deficiency) were consecutively recruited and followed up for one year. Clinical, radiological (bone age and MRI) and biochemical parameters were studied. RESULTS: Children with hypoplastic pituitary (pituitary height < 3 mm) had more severe height deficit (height for age Z-score -6.0 vs. -5.0) and retardation of skeletal maturation (bone age chronological age ratio of 0.59 vs. 0.48) at baseline as compared to children with normal pituitary heights (p < 0.05 for both). After one year of GH therapy, height for age Z scores and percentage change in height for age Z scores were significantly higher in children with hypoplastic pituitaries (13.8 ± 3.6 and 28.7 % vs. 11.2 ± 4.1 and 21.4 %). Significant co-relation was observed between pituitary height and height for age Z-scores at baseline (r = 0.39, p < 0.05). The predicted adult height using Tanner Whitehouse-2 equations improved from 140.8 to 152.3 cm in children with hypoplastic pituitary when compared to an increase from 145.8 to 153.5 cm observed in children with normal pituitary height (p < 0.05). CONCLUSIONS: Indian growth hormone deficient children with hypoplastic pituitary respond better to therapy with GH in short term.


Asunto(s)
Enanismo Hipofisario/tratamiento farmacológico , Hormona Liberadora de Gonadotropina/uso terapéutico , Crecimiento/efectos de los fármacos , Hipófisis/anomalías , Adulto , Niño , Enanismo Hipofisario/sangre , Enanismo Hipofisario/fisiopatología , Femenino , Estudios de Seguimiento , Hormona de Crecimiento Humana/sangre , Humanos , India , Imagen por Resonancia Magnética , Masculino , Hipófisis/fisiopatología , Estudios Prospectivos
3.
Mov Disord ; 21(11): 1986-90, 2006 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-16991145

RESUMEN

We report on a young woman who survived acute liver failure (ALF) without liver transplant. During the ALF, she developed a disabling, levodopa-unresponsive, symmetrical Parkinsonism. This was characterized by severe bradykinesia, mild rigidity, mutism, and prominent gait impairment. Magnetic resonance imaging (MRI) showed bilateral T1W pallidal hyperintensities. Parkinsonism and MRI changes remitted in parallel with normalization of hepatic function. We implicate excessive pallidal manganese deposition secondary to ALF in the pathogenesis of this neuroradiological syndrome. Though hitherto unreported, we propose that Parkinsonism with T1W pallidal hyperintensities may not be uncommon in ALF.


Asunto(s)
Globo Pálido/patología , Fallo Hepático Agudo/complicaciones , Fallo Hepático Agudo/patología , Imagen por Resonancia Magnética , Enfermedad de Parkinson Secundaria/patología , Trastornos Parkinsonianos/etiología , Adulto , Antiparkinsonianos/efectos adversos , Femenino , Humanos , Levodopa/efectos adversos , Enfermedad de Parkinson Secundaria/inducido químicamente , Trastornos Parkinsonianos/tratamiento farmacológico , Trastornos Parkinsonianos/patología
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