RESUMEN
Potentiometric detection of copper ion over chemically interactive and electrically responsive chitin grafted polyaniline (Chit-g-PANI) electrode has been demonstrated for natural as well as artificial samples under optimized conditions using a portable sensing setup. The physical properties and chemical structure of developed electrode were evaluated by different Infrared spectrometry, X-ray diffraction, scanning electron microscope, thermal gravimetric analyzer and ASTM methods. The result indicates the formation of electrically responsive, chemically interactive, stable grafted hybrid matrix for durable and reproducible potentiometric electrode for a self-designed portable potentiometric cell. The potentiometric response of electrode toward Cu2+ ions follows the nernst relation in the range from 1 to 103 ppm with detection limit of 13.77 ppm and negligible interference for different co-existing cations and anions. Further, on the basis of interaction between cupric ion and Chit-g-PANI matrix, the sensing mechanism and ion to electron transduction has been discussed along with future prospects for on-site applications.
Asunto(s)
Compuestos de Anilina/química , Quitina/química , Cobre/análisis , Potenciometría/métodos , Electrodos , Agua Subterránea/química , Concentración de Iones de Hidrógeno , Iones , Espectroscopía Infrarroja por Transformada de Fourier , Termogravimetría , Aguas Residuales/química , Contaminantes Químicos del Agua/análisis , Difracción de Rayos XRESUMEN
[6]-Shogaol (1) was isolated from Zingiber officinale. Twelve novel compounds have been synthesized and evaluated for their Brugia malayi thymidylate kinase (BmTMK) inhibition activity, which plays important role for the DNA synthesis in parasite. [6]-Shogaol (1) and shogaol with thymine head group (2), 5-bromouracil head group (3), adenine head group (4) and 2-amino-3-methylpyridine head group (5) showed potential inhibitory effect on BmTMK activity. Further molecular docking studies were carried out to explore the putative binding mode of compounds 1-5.
Asunto(s)
Antinematodos/síntesis química , Brugia Malayi/enzimología , Catecoles/síntesis química , Diseño de Fármacos , Inhibidores Enzimáticos/síntesis química , Nucleósido-Fosfato Quinasa/antagonistas & inhibidores , Animales , Antinematodos/química , Antinematodos/aislamiento & purificación , Antinematodos/farmacología , Brugia Malayi/efectos de los fármacos , Catecoles/química , Catecoles/aislamiento & purificación , Catecoles/farmacología , Inhibidores Enzimáticos/química , Inhibidores Enzimáticos/aislamiento & purificación , Inhibidores Enzimáticos/farmacología , Zingiber officinale/química , Simulación del Acoplamiento Molecular , Estructura Molecular , Nucleósido-Fosfato Quinasa/genética , Proteínas RecombinantesRESUMEN
In continuation of our drug discovery programme on Indian medicinal plants, we isolated an unusual amino acid, i.e. 2-amino-5-hydroxyhexanoic acid (1) from the seeds of Crotalaria juncea. The 2-amino-5-hydroxyhexanoic acid (1) showed dose dependent lipid lowering activity in the in vivo experiments and also showed good in vitro antioxidant activity. The cyclized compound, 3-amino-6-methyltetrahydro-2H-pyran-2-one (2) showed better lipid lowering and antioxidant profile than the parent compound 1.
