Prognostic Implication of Selective Serotonin Reuptake Inhibitors in Osseointegration of Dental Implants: A 5-year Retrospective Study.

AIM: Dental implants are the preferred treatment modality in the present edentulous era. Selective serotonin reuptake inhibitors (SSRIs) have detrimental effect on bone density. The present study was conducted to determine the effect of SSRIs on the success rate of dental implants. MATERIALS AND METHODS: The present study was conducted on 352 patients of both genders with 680 dental implants. History of depression and SSRI medication was retrieved. Patients were divided into two groups. Group I (110 patients, 230 dental implants) patients were on SSRI, while group II (242 patients, 450 dental implants) patients were non-SSRI. In all patients, the implant failure rate was recorded. RESULTS: In group I, 35 patients were >50 years, while 75 were <50 years of age. In group II, 60 patients were >50 years, while 182 were <50 years of age. The difference was significant (p < 0.05). Group I had 45 males and 65 females, while group II comprised of 105 males and 137 females. Group I showed 25 implant failures and group II had 21 implant failures. Age group >50 years showed 12 implant failures while <50 years had 13 in group I compared with 10 in patients >50 years and 11 in patients with <50 years of age; 56% smokers had implant in group I as compared with 60% failure in group II. In group I, 27% diabetic patients had failures as compared with 13.4% in group II. The difference was significant (p < 0.05). Group I showed maximum failures in terms of loosening of screw (8) followed by fracture of implant (7), peri-implantitis (6), and fracture of screw (4), whereas in group II, 7 cases were of loosening of screw, 6 cases were of fracture of screw, 5 cases of fracture of implant, and 3 cases of peri-implantitis. The difference was nonsignificant (p > 0.05). CONCLUSION: Selective serotonin reuptake inhibitors cause increased osteoclastic activity, leading to bone loss and implants placed in patients with history of depression are more prone to failures. CLINICAL SIGNIFICANCE: Failure rates of dental implants are significantly increased in patients taking SSRIs due to depression. Careful case analysis and history of depression may minimize the failure rates.

Evaluation and Comparison of the Effect of Different Border Molding Materials on Complete Denture Retention: An in vivo Study.

AIM: Different border molding materials have different qualities which help in recording fine details of tissues. The present study was conducted to evaluate and compare the effect of different border molding materials on complete denture retention. MATERIALS AND METHODS: The present study was conducted on 10 completely edentulous patients in the age group of 50 to 70 years. On each patient, three different border moldings were completed. In group I, border molding was done with green stick impression compound. In group II, border molding was done with putty consistency addition silicone. In group III, border molding and final impression were done by polyether impression material in a single step. Permanent denture bases were fabricated with wire loop at the center. Retention was assessed in all three groups using a digital force gauge. RESULTS: Upon data compilation and preparation of spread sheets for concerned groups, it was subjected to statistical analysis using Statistical Package for the Social Sciences (SPSS) software version 21.0 for Windows. Mean age ± standard deviation (SD) was 57.40 ± 8.46 in group I, 57.40 ± 8.46 in group II, and 57.40 ± 8.46 in group III. The difference was nonsignificant (p > 0.05). The overall mean value for the group I was 4.59 ± 0.81. For group II, it was 4.7 ± 0.81. For group III, it was 6.72 ± 0.81. The difference was significant (p < 0.05). CONCLUSION: Green stick compound with light body final wash showed the lowest mean values of complete denture retention. Dentures made using polyether final impression material showed the highest mean values of complete denture retention followed by putty rubber base border molding with light body final wash. CLINICAL SIGNIFICANCE: In this study, polyether showed the highest mean retentive value compared with other tested materials; therefore, it could possibly provide some future innovative means in achieving optimal denture retention.

Evaluation of the Efficacy of Different Mixing Techniques and Disinfection on Microbial Colonization of Polyether Impression Materials: A Comparative Study.

AIM: This study aims to determine the role of mixing techniques of polyether impression materials and efficacy of disinfection on microbial colonization of these impression materials. MATERIALS AND METHODS: Polyether impression material was mixed using two methods: First by hand mixing (group I) and second using an automixer (group II) with a total of 100 samples. Four microbial strains were studied, which included Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. After incubation, the bacterial colonies were counted, and then, disinfectant solution was applied. The effect of disinfection solution was evaluated for each specimen. RESULTS: The surface of polyether impression materials mixed with an automixer has less number of voids and overall a smoother surface as compared with the hand-mixed ones. On comparing the disinfection procedures, i.e., specimens without any disinfection and specimens after disinfection, statistically highly significant difference was seen between all the groups. CONCLUSION: We can conclude that impression mixing procedures are important in determining the surface characteristics of the impression and ultimately the colonization of bacteria and also determine the importance of disinfection on microbial colonization. CLINICAL SIGNIFICANCE: This study emphasises the deleterious role of nosocomial infections and specific measures that should be taken regarding the prevention of such diseases. Dental impressions are proved to be a source of such infections and may lead to transmission of such diseases. Thus, proper measures should be taken right from the first step of impression taking to minimizing and preventing such kind of contaminations in clinical practice.