RESUMEN
Purpose: Dark circles and pigmentation around the eyes are common reasons people see dermatologists. An effective assessment of the severity of infraorbital color and texture differences is critical for determining appropriate treatment. Evaluation of the visual severity of cases is mostly based on visual inspection. Treatment efficiency is often measured using patient questionnaires in many cases. The subjectivity of assessments may lead to a prolonged healing process, misdiagnosis, and excessive use of drugs or chemicals. Patients and Methods: In this study, a computer-aided objective evaluation approach was proposed for grading periorbital facial rejuvenation. This approach is based on the analysis of numerical features extracted from different facial regions in digital images. Healing was objectively graded by evaluating data clusters formed using the extracted features. Accordingly, an increase in the visual similarity between paired facial regions is accepted as an indicator of healing, which directly affects the form of data clusters. An intracluster validity index was measured to evaluate the clusters as dense and well separated. A total of 144 facial regions were extracted and examined, and the automatically calculated grades were compared with expert evaluations. Results: The cosmetic effects of the experimental drug were evaluated during the experiments, and expert grades were accepted as the ground truth. The results show that the proposed automated grading approach can evaluate rejuvenation with an accuracy of up to 0.91 accuracy in the upper orbital region. Conclusion: This study concluded that the proposed data-clustering-based approach is promising and can be functional without any special instruments.
RESUMEN
Purpose: We performed an assessment of the rejuvenation effect of an amino acid and hyaluronic acid mixture in the periorbital area. Methods: A total of 23 of the 35 participants completed all application sessions and measurements. These 23 women were aged 30-55 years. A hyaluronic acid and amino acid mixture was injected into the participants' periorbital area. Three sessions of application with 15-day intervals were undertaken. Subjects' age, height, weight, smoking status, and sport participation were recorded. A photonumeric dark circle scale and Fitzpatrick's periorbital wrinkling classification were used for evaluation of dark circles and wrinkles in the periorbital area. Anatomical measurements (height of upper and lower eyelids) were done using ImageJ and a skin-analysis system (Observ 520). Results: The 23 women had a mean age of 42.46±9.33 years, mean height 164.46±4.96 cm, and mean weight 63.94±8.26 kg. Before the sessions, the mean heights of the upper eyelids were 1.24±013 cm (right) and 1.21±013 cm (left), while those of the lower eyelids were 0.98±014 cm (right) and 0.97±0.17 cm (left). One month after the third session, mean upper-eyelid heights were 1.30±0.09 cm (right) and 1.28±0.11 cm (left) and lower-eyelid ones 1.02±0.11 cm (right) and 1.02±0.13 cm (left). Dark-circle and wrinkle-scale scores showed significantly positive results between before the sessions and 1 month after the third session. Conclusion: A hyaluronic acid and amino acid mixture can be used to rejuvenation of the periorbital area in women aged 30-55 years.
