1.
Bioorg Med Chem Lett
; 20(1): 222-7, 2010 Jan 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19932965
RESUMEN
The structure-activity relationship (SAR) for three series of lactam-fused chroman derivatives possessing 3-amino substituents was evaluated. Many compounds exhibited affinities for both the 5-HT(1A) receptor and the 5-HT transporter. Compounds 45 and 53 demonstrated 5-HT(1A) antagonist activities in the in vitro cAMP turnover model.