Effects of Anatolian Propolis and Hypertonic Saline Combination Nasal Spray on Allergic Rhinitis Symptoms: A Prospective, Multicenter Study.

Objectives: This study aimed to evaluate how Rhinapi nasal spray affects symptoms of allergic rhinitis. Methods: In this prospective, multicenter, observational study, 10,000 patients (comprising 5028 males and 4972 females) exhibiting symptoms of allergic rhinitis (namely, nasal discharge, sneezing, nasal itching, and nasal obstruction) from different centers in different regions of Turkey were enrolled in the study between March 2022 and March 2023. All the patients wanted to participate in the study and were administered Rhinapi one puff to each nostril three times a day, for a period of 3 weeks. Total symptom scores, quality of life (QoL) scores, and otolaryngological examination scores were evaluated before and 3 weeks after treatment. Results: The scores for discharge from the nose, sneezing, nasal pruritus, and blockage of the nose all indicated improvement when compared to pre-medication and post-medication. This difference achieved statistical significance (P < .001). The mean total symptom score fell following treatment (P < .001): whilst the score was 11.09 ± 3.41 before administering Rhinapi; after administration, the average score was 6.23 ± 2.41. The mean QoL scores also altered after medication (P < .001), improving from a mean value of 6.44 ± 1.55 to a mean of 7.31 ± 1.24. Significant improvement was also noted in the scores for conchal color and degree of edema after the treatment had been administered (P < .001). Conclusion: The study demonstrates that Rhinapi nasal spray decreases total symptom scores, and results in improved QoL and otolaryngological examination scores. Propolis spray may be recommended for patients with allergic rhinitis alongside other treatments.

Comparison of death and survival cervical necrotizing fasciits cases.

BACKGROUND: Cervical Necrotizing Fasciitis (CNF) is associated with a high mortality rate. The occurrence of mediastinitis with CNF may increase mortality up to 70%. AIMS: We aimed to identify the differences between surviving and deceased cases. METHODS: The present study was conducted retrospectively by scanning the files of 16 patients between the ages of 19-71 who were diagnosed with CNF. Patients were divided into two groups as the surviving patient group (SPG) and the deceased patient group (DPG). Both groups were compared in terms of age, gender, Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score, duration of symptom onset to hospital admission, use of antibiotherapy prior to admission, duration of hospitalization, presence of diabetes mellitus (DM), presence of dental etiology, mediastinitis, and respiratory distress at the time of admission. RESULTS: Diabetes mellitus was the most common comorbid disease. 5 out of 7 deceased patients had DM. Dental events were the most common etiology. Rapid surgical debridement and airway management was the first treatment method. The most frequently isolated species in the culture was Streptococcus. 6 of 11 patients who developed mediastinitis deceased at the end of the process. CONCLUSION: Dental pathologies mostly play a role in the etiology. It is obvious that dentists, another occupational group that frequently encounters this patient group, have a critical role in this process. Therefore, precise attention should be given to dental problems in patients with diabetes, and hospitalization and initiation of broad-spectrum antibiotherapy should be considered in case of suspicion of deep neck infection.

Evaluation of the language development of children with cochlear implant users living in a multilingual environment.

OBJECTIVE: To evaluate the effect of second language exposure on Turkish speaking skills in cochlear implant (CI) users. METHODS: Children living in mono and bilingual families, who underwent unilateral cochlear implant due to congenital severe to profound, or profound hearing loss, were examined. The fifty six children with a chronological age younger than 8 and a language age of 2-6 years were included the study. The Denver II Developmental Screening Test was used for identifying of pre-implant speech and development. The duration of implant use was also documented. Languages spoken at the patients' homes were divided into 4 categories: T/K: Predominantly Turkish/Kurdish, K/T: Predominantly Kurdish/Turkish, T/T: Just Turkish, A/T: Predominantly Arabic/Turkish. The CAP (Categories of Auditory Performance), SIR (Speech Intelligibility Rating), The Turkish Version Test of The Early Language Development (TELD-3:T),. The IT-MAIS (Infant Toddler Meaningful Auditory Integration Scale), MUSS (Meaningful Use of Speech Scale) were used to evaluate the language development of the patients. Changes in IT-MAIS and MUSS scores in the last two years were also evaluated. RESULTS: The all children received their implants before age of 6 years. The average duration of cochlear implant use of children was 38,43 ± 11,64 months. The mean pre-implant speech age was 6,8 ± 2,13 months. There was no significant difference between the groups in terms of the CAP and SIR scores. In TELD-3:T scores, there was no significant difference between the groups except for the receptive raw scores. The Arabic/Turkish group had significantly lower receptive raw scores. This group also had significantly lower mother educational level. In IT-MAIS and MUSS scores, no significant difference was found between the groups. CONCLUSIONS: Our study supports the opinion that exposure to a second language at home does not affect the acquisition of the language of education in children using CI.

Culturally modified olfactory test adapted to East-Turkey: A comparison with Sniffin' Sticks.

BACKGROUND: Although the "Sniffin' Sticks" test (SST) is a widely used odor test, aplicability of odor tests is limited because of the high cost of the test and the regional-cultural differentiation of odor recognition. We aimed to evaluate our regional odor norms by applying the SST with a Modified odor test (MOT) we created for this study, and to develop a test similar to the SST, which was less expensive and probably had a higher odor definition for our region. METHODS: This study includes 201 healthy volunteers: 91 men and 110 women over the age of 18 were included in the study. Tests were compared by applying the SST and MOT to all volunteers. RESULTS: In all subjects, for the SST: the mean Threshold score (TS), Discrimination score (DS), and Identification score (IS) were, respectively, 10.73 ± 2.35, 11.11 ± 11.94 and 11.32 ± 2.15. TheTDI mean score was found to be 33.11 ± 5.9. In the TDI score, the 10th percentile value was found to be 26. For the MOT, the mean TS(mTS), DS(mDS), and IS(mIS) were 10.88 ± 2.31, 12 ± 2.06, and 11.95 ± 2.07, respectively, the modified test TDI(mTDI) mean was 34.68 ± 6.47. The mTDI 10th percentile value was found to be 26. In all volunteers, there was no statistically significant difference between the two tests for the mean threshold score, while the difference in the mean discrimination score, the average identification score, and the average TDI (thresold, discrimination, sum of identification scores) score was statistically significant (P < .01). CONCLUSION: This study is the first study to compare the SST and the MOT in our region. Making low-cost modifications by adding more probable smells to the smell tests and using them in studies involving more participants will be more meaningful in evaluating normative odor scores and will result in more widespread use.

Comparison of patients with malignant or benign laryngeal lesions and healthy indivduals in terms of haematological inflammatory parameters.

BACKGROUND: The aim of this study is to compare neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) values, which are inflammatory parameters, in precancerous and cancerous lesions and to determine whether there is a parameter that can be used in the early diagnosis of laryngeal squamous cell carcinoma. METHODS: In this retrospective study, 174 patients who were benign as a result of pathology, 122 patients who were malignant, 39 patients who were premalignant (335 patients in total) and 117 normal individuals were included. Data groups were divided into 4 groups as benign laryngeal lesion(BLL), precancerous laryngeal lesion (PLL), malignant laryngeal Lesion (MLL) and control group (CG). In addition, the PLL group was subdivided into mild dysplasia (MiD), Moderate Dysplasia (MoD) and severe dysplasia-carcinoma in situ (SeD/CIS). NLR, PLR and other parameters were calculated. RESULTS: NLR and PLR values were significantly different between the groups. (P = .000, P = .002) The mean NLR was higher in the MLL and PLL groups, and was lower in the BLL and control groups. The mean PLR was also higher in the MLL and PLL groups. When the groups were compared in pairs, there was a significant difference between BLL and MLL (P = .001) and MLL and CG (P = .006). The PLL group was subdivided into MiD, MoD and SeD/CIS. There was a significant difference in NLR when CG and other subgroups were compared (P = .027). Significant differences were found between CG and SeD when the groups were compared in pairs (P = .007). There was no significant difference between the groups in terms of PLR and dysplasia (P = .516). CONCLUSION: As revealed in this study, these rates were low in the CG and BLL groups and high in the MLL group, so they could be used as markers to differentiate malignant lesions.

Evaluation of symptoms of preopoperative and postoperative psychosomatic screening in children with adenoidectomy and adenotonsillectomy.

INTRODUCTION: Adenoidectomy and adenotonsillectomy are very common operations in childhood. It is important to clarify their effects on this age group; in this study, we aimed to investigate the effects of the causative agent on children's mental health by using scales that help to screen for indications of mental disorders in children, who have had adenoidectomy or adenotonsillectomy, both before and after surgery. In this way, we aimed to investigate the effects of this factor on children's mental health. MATERIALS AND METHODS: The study included 82 children aged 6-12 years with signs of upper respiratory tract obstruction or recurrent adenotonsilitis. Adenotonsillectomy was performed in 41 patients included in the study and adenoidectomy was performed in 41 patients included in the study. 40 healthy children matched with the patient groups in terms of age and gender were included in the control group. Patients, were divided into three groups, those who underwent adenoidectomy, patients undergoing adenotonsillectomy and those in the control group Preoperative and postoperative questionnaires were used to investigate the effect of tonsillectomy or adenoidectomy on the mental health of children. The Parents' Form for the Strengths and Difficulties Questionnaire, the Parental Form for the Children's Anxiety Screening Scale, the Sleeping Scale for Children and the Quality of Life Scale for Children were used in the screening. RESULTS: In children, who underwent adenoidectomy/adenotonsillectomy due to recurrent infection and adeno/adenotonsillar hypertrophy; it was seen that there was a significant decrease in the scores for the Strengths and Difficulties Questionnaire, the Anxiety Screening Scale in Children, and the Sleep Scale in Children, and a significant increase in Quality of Life Scale for Children scores. OUTCOME: In conclusion, adenoidectomy/adenotonsillectomy in children with sleep apnea due to recurrent episodes of infection and adeno/adenotonsillar hypertrophy was thought to prevent further neurobehavioral problems, likely to become more complex in the future, and to improve quality of life.