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The purpose of this study was to evaluate the relationships between subjective, self-reported cancer related fatigue (CRF) and objective measures of muscular strength and fatigability in cancer survivors. A total of 155 cancer survivors (60 ± 13 years of age) completed a questionnaire for the assessment of CRF, along with assessments of handgrip strength, quadriceps strength and fatigability (reduced force/torque). Fatigability was measured by completing 15 maximal isokinetic contractions of the knee extensors (QFI). Spearman's rho correlation coefficients were calculated as pairwise combinations of the numerical and categorical dependent measures. Categorical variables were analyzed via nonparametric means of association. This included a 4×4 chi-square to test whether cancer stage (0-4) was independent of fatigue status (none, mild, moderate, severe) and whether cancer treatment (surgery, radiation, chemotherapy, or combinations of these) was independent of fatigue status. None of the physiological strength and fatigue measures were significantly correlated to overall perceived fatigue or any of the subscales. Cancer stage and treatment type were also not significantly related to fatigue status (likelihood ratio = .225, Cramer's V = .228; likelihood ratio = .103, Cramer's V = .369, respectively). Our results show that levels of patient reported fatigue severity were not significantly related to muscular fatigability or strength. As a result, cancer patients experiencing fatigue may benefit from following the standard exercise guidelines for cancer survivors, regardless of their levels of self-reported fatigue.
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CONTEXT: The quality of running mechanics is often characterized by limb pattern symmetry and used to support clinical decisions throughout the rehabilitation of lower-extremity injuries. It is valuable to ensure that gait analyses provide stable measures while not asking an individual to complete an excessive number of running strides. The present study aimed to determine the minimum number of strides required to establish a stable mean symmetry index (SMSI) of discrete-level measures of spatiotemporal parameters, joint kinematics, and joint kinetics. Further, the study aimed to determine if differences occurred between random and consecutive strides for directional and absolute symmetry indices. DESIGN: Descriptive laboratory study. METHODS: A sequential average was used to determine how many strides were required to achieve a SMSI within a 60-second trial. Multiple 2-factor repeated-measure analysis of variances were used to determine if differences between bins of strides and symmetry calculations were significantly different. RESULTS: A median SMSI was achieved in 15 strides for all biomechanical variables. There were no significant differences (P > .05) found between consecutive and random bins of 15 strides within a 60-second trial. Although there were significant differences between symmetry calculation values for most variables (P < .05), there appeared to be no systematic difference between the numbers of strides required for stable symmetry for either index. CONCLUSIONS: As 15 strides were sufficient to achieve a SMSI during running, a continued emphasis should be placed on the number of strides collected when examining interlimb symmetry.
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Traumatismos de la Pierna , Carrera , Fenómenos Biomecánicos , Marcha , Análisis de la Marcha , Humanos , Articulación de la Rodilla , Carrera/lesionesRESUMEN
Individuals returning to sport after anterior cruciate ligament reconstruction (ACLR) are at an increased risk of sustaining a subsequent ACL injury. It is suspected that increased reliance on visual information to maintain stability may factor into this increased risk. The connection between visual reliance and ACLR is not well understood during dynamic tasks. Examination of the proposed visual reliance may help improve returning to sport standards and reduce subsequent ACL injury risk. A total of 12 ACLR individuals and 12 age- and sex-matched controls completed several trials of a normalized dynamic hop task on both limbs under 3 different visual conditions (eyes open, low visual disruption, and high visual disruption). Stroboscopic eyewear were worn by each participant to disrupt vision during testing. Ground reaction force data were collected during landing. Dynamic postural stability was assessed using 2 separate calculations: dynamic postural stability index and time to stability. No significant statistical interactions or group differences were observed. The stroboscopic eyewear did increase the medial-lateral stability index from the eyes open to the low visual disruption condition (P < .05). These findings suggest that ACLR individuals do not rely on visual information more than controls during a dynamic hop task.
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Lesiones del Ligamento Cruzado Anterior , Reconstrucción del Ligamento Cruzado Anterior , Deportes , Ligamento Cruzado Anterior , Lesiones del Ligamento Cruzado Anterior/cirugía , Atletas , HumanosRESUMEN
BACKGROUND: Cancer and cancer treatments negatively affect somatosensory, vestibular, and visual inputs that regulate postural stability and balance, increasing the risk of falling. Exercise training has been shown to mitigate other negative side effects of cancer treatments, such as reducing peripheral neuropathy. RESEARCH QUESTION: How does 12 weeks of supervised exercise training influence postural stability in cancer survivors who receive chemotherapy? METHODS: Postural stability of cancer survivors (n = 25; mass = 79.0 ± 22.6 kg; height = 1.66 ± 0.08 m; age = 61 ± 10 years) receiving chemotherapy was assessed prior to and following a 12-week individualized exercise training program by quantifying changes in center of pressure data. A series of 2-factor (pre/post x condition) analysis of variance with repeated measures were used to identify differences between conditions and pre- and post- training program on time and frequency domain measures. RESULTS: Mediolateral root mean square excursion (p = 0.040; es = 0.20) and resultant mean frequency (p = 0.044; es = 0.29) of the center of pressure trajectory were found to be significantly different between pre- and post-training program. Further, participants dealt better with perturbations after completing the training program by reducing mediolateral root mean square excursion and 95 % confidence ellipse when visual stimulus was removed. SIGNIFICANCE: Supervised exercise training in cancer patients undergoing chemotherapy improves postural stability in the mediolateral direction. Given that mediolateral movement of the center of pressure has previously been associated with fallers in other populations, exercise training during cancer treatments may be beneficial.
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Supervivientes de Cáncer , Terapia por Ejercicio , Neoplasias , Accidentes por Caídas/prevención & control , Anciano , Ejercicio Físico , Humanos , Persona de Mediana Edad , Neoplasias/tratamiento farmacológico , Enfermedades del Sistema Nervioso Periférico , Equilibrio PosturalRESUMEN
Over the past decade, efforts to reduce emissions of particulate matter (PM) and oxides of nitrogen (NO + NO2, or NOx) from heavy-duty diesel vehicles (HDDVs) have led to the widespread adoption of both Diesel Particulate Filters (DPFs) to control PM and Selective Catalytic Reduction (SCR) to control NOx. We evaluated the performance of DPFs and SCR with 13,327 real-world fuel-based Black Carbon (BC) and NOx emission factors from 9,167 unique heavy-duty vehicles (primarily HDDVs) measured at four sites in California (two ports, two highways) from 2011 to 2018. BC emission factors have decreased by 90% during the past decade. At the same time, BC distributions have become increasingly skewed toward "high-emitters" - e.g., the portion of the HDDV fleet responsible for half of all BC emissions has decreased from ~16% to ~3%. NOx emission factors have also decreased over the past decade, but by only 31%. They remain roughly five times greater than in-use thresholds.We examined changes in BC and NOx emissions with engine age. BC emissions from DPF-only trucks decreased slightly but insignificantly, by 6 ± 15 mg/kg fuel per year, while for DPF+SCR trucks they increased by 5 ± 3. These changes are less than 5% of in-use thresholds. The annual increase in NOx emissions with age was much greater: 1.44 ± 0.28 g/kg for older SCR trucks without on-board diagnostic (OBD) capabilities and 0.48 ± 0.35 for newer trucks with OBD, roughly 20- 50% of in-use thresholds. Paired t-tests on the over 600 vehicles that were observed in multiple campaigns were consistent with these results. Observed changes in BC emissions with age were best fit with a "gross emitter" model assuming an annual DPF failure rate of 0.83 ± 0.01% for DPF-only trucks and 0.56 ± 0.01% for DPF+SCR trucks.Implications: These observations of real-world HDV emission factors have several major implications for regulatory efforts to reduce them. The increasing importance of a relatively small number of high BC emitters suggests that widespread sampling of the on-road fleet will be necessary to identify these vehicles. On the other hand, the much more ubiquitous deterioration in NOx control measures may be better addressed by incorporating on-board diagnostic systems, with telematic data transfer when possible, into inspection and maintenance programs. These NOx observations also highlight the need for strengthening heavy-duty SCR durability demonstration requirements.
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Contaminantes Atmosféricos , Emisiones de Vehículos , Contaminantes Atmosféricos/análisis , California , Monitoreo del Ambiente , Vehículos a Motor , Material Particulado/análisis , Emisiones de Vehículos/análisisRESUMEN
BACKGROUND: Persons with transtibial amputation report curb negotiation is more challenging than negotiating stairs. It is unknown if amputation technique influences curb negotiation ability. Traditional transtibial amputation surgical techniques do not join the distal tibia and fibula (non-Ertl), whereas a transtibial osteomyoplastic amputation (Ertl) creates a "bone bridge" connection. The Ertl may facilitate ambulation through greater residual end load bearing. OBJECTIVES: To determine if ability to negotiate a curb differs between Ertl and non-Ertl groups. STUDY DESIGN: Cross-sectional study. METHODS: Non-Ertl (n = 7) and Ertl (n = 5) participants ascended a 16-cm curb using their amputated and intact limb as the lead limb. Motion data and ground reaction forces were used to calculate ankle, knee, hip, and total limb work for ground and curb steps. RESULTS: On the ground, the amputated limb of both groups produced less work than the intact limb. In contrast, on the curb step, the Ertl amputated limb generated more net hip work than the non-Ertl amputated limb. As a result, the net limb work of the Ertl amputated limb did not differ from the non-amputated limbs. CONCLUSION: Comparisons between the amputated limb of Ertl and non-Ertl groups suggest use of a different curb stepping pattern between groups. CLINICAL RELEVANCE: These findings suggest that surgical technique may influence curb negotiation ability in individuals with transtibial amputation. Specifically, the Ertl group is able to produce more hip power than the non-Ertl group while negotiation a curb which may be attributed to the increased ability to end-load bear on the residual limb.
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Amputación Quirúrgica/métodos , Amputados , Tibia/cirugía , Caminata/fisiología , Anciano , Fenómenos Biomecánicos , Estudios Transversales , Humanos , Persona de Mediana EdadRESUMEN
Periodic regeneration is required to clean the diesel particulate filter (DPF) of heavy-duty diesel vehicle. In this study we analyze real-time particulate matter (PM) mass, particle number, and black carbon emissions during steady state driving active and passive diesel particulate filter (DPF) regenerations on a heavy-duty chassis dynamometer. Regeneration PM emissions were dominated by particles with count median diameter<100nm, with the majority <50nm. Results indicate that vehicle activity during DPF loading significantly affects regeneration particulate emissions. Average PM emission rates (gPM/h) from the 2010 MY vehicle were higher than the 2007 MY vehicle during all regeneration conditions in this study. Sequential forced-active regenerations resulted in reduced particulate mass emissions, but not in reduced particle number emissions, suggesting incomplete stored PM removal or effects of after-treatment fuel injection. Black carbon emission factors (EFBC) were 3.4 and 21 times larger during driving-active regeneration than during a 50 mph steady state cruise with a recently regenerated DPF for the 2007 and 2010 MY vehicle, respectively. Real-time PM emissions rates were lower during passive regeneration of the 2010 MY DPF, suggesting more modern passive regeneration technologies reduce total on-road particulate and ultrafine particulate emissions.
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BACKGROUND: Some comparisons between walking gait of obese and non-obese adults have been made during barefoot conditions, and others while shod. Methodological differences, footwear conditions, and gait speed disparities among the research done on overweight individuals were the factors motivating the present study. RESEARCH QUESTION: The present study was designed to compare gait kinematics and kinetics of obese adults between two footwear conditions (barefoot versus shod) at a set walking speed. METHODS: Ten obese (body mass indexâ¯>â¯30â¯kg.m-2), but otherwise healthy adults (ageâ¯=â¯26⯱â¯3 years, heightâ¯=â¯1.79⯱â¯0.10â¯m, massâ¯=â¯108.46⯱â¯13.25â¯kg) participated in this study. Ground reaction forces and 3D kinematic data were simultaneously collected as participants walked overground at 1.5 m.s-1 in barefoot and shod conditions. RESULTS: Walking barefoot reduced ankle, knee, and hip ranges of motion, and stride length, stance time, and double support time were also reduced. Kinetic outcomes included smaller peak vertical and anterior-posterior ground reaction forces and knee joint moments while barefoot. SIGNIFICANCE: Footwear condition significantly influences key gait variables in obese adults. Conflicting conclusions from previous investigations of gait in obese adults may be a consequence of differing footwear conditions.
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Marcha/fisiología , Obesidad/fisiopatología , Zapatos , Adulto , Fenómenos Biomecánicos , Femenino , Humanos , Cinética , Articulación de la Rodilla/fisiología , Masculino , Rango del Movimiento Articular , Velocidad al Caminar/fisiología , Adulto JovenRESUMEN
Lisano, JK, Smith, JD, Mathias, AB, Christensen, M, Smoak, P, Phillips, KT, Quinn, CJ, and Stewart, LK. Performance and health-related characteristics of physically active men using marijuana. J Strength Cond Res 33(6): 1659-1669, 2019-The influence of chronic marijuana use on the performance and health of physically active individuals has yet to be fully elucidated. The purpose of this study was to explore pulmonary function, aerobic and anaerobic fitness, strength, serum testosterone, cortisol, C-reactive protein (CRP), Δ-9-tetrahydrocannabinol (THC), 11-nor-9-carboxy-Δ-9-tetrahydrocannabinol (THC-COOH), and 11-hydroxy-Δ-9-tetrahydrocannabinol (THC-OH) concentrations in a physically active population either using or not using marijuana. Healthy, physically active males (N = 24) were compared based on their marijuana-use status: marijuana users (MU; n = 12) and nonusers (NU; n = 12). Statistical analysis (p = 0.05) revealed no difference between groups for age, body mass, body mass index, body fat, forced expiratory volume in 1 second percentage, VO2max, anaerobic power output, strength measures, testosterone, or cortisol concentrations. Although not statistically significant, MU showed a trend to fatigue to a greater percentage of absolute power output than NU from the beginning to the end of the Wingate Anaerobic Power Assessment (p = 0.08, effect size = 0.75). C-reactive protein in MU (1.76 ± 2.81 mg·L) and NU (0.86 ± 1.49 mg·L) was not significantly different (p = 0.60) but placed MU at moderate risk and NU at low risk for cardiovascular disease. Anaerobic fatigue was the only performance variable to show a trend for difference between groups. These results suggest that marijuana use in physically active males may not have significant effects on performance; however, it may be linked to elevated concentrations of CRP which place users at a higher risk for cardiovascular disease.
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Fumar Marihuana/efectos adversos , Fumar Marihuana/fisiopatología , Adulto , Proteína C-Reactiva/metabolismo , Dronabinol/análogos & derivados , Dronabinol/sangre , Prueba de Esfuerzo , Volumen Espiratorio Forzado , Humanos , Hidrocortisona/sangre , Masculino , Fumar Marihuana/sangre , Fuerza Muscular , Aptitud Física , Testosterona/sangre , Adulto JovenRESUMEN
We investigate the effects of sulfate and nitrate on the formation and evolution of secondary organic aerosol formed in the aqueous phase (aqSOA) from photooxidation of two phenolic carbonyls emitted from wood burning. AqSOA was formed efficiently from the photooxidation of both syringaldehyde (C9H10O4) and acetosyringone (C10H12O4) in ammonium sulfate and ammonium nitrate solutions, with mass yields ranging from 30% to 120%. Positive matrix factorization on the organic mass spectra acquired by an Aerosol Mass Spectrometer revealed a combination of functionalization, oligomerization, and fragmentation processes in the chemical evolution of aqSOA. Functionalization and oligomerization dominated in the first 4 h of reaction, with phenolic oligomers and their derivatives significantly contributing to aqSOA formation; and oxidation of the first-generation products led to an abundance of oxygenated ring-opening products. Degradation rates of syringaldehyde and acetosyringone in nitrate solutions were 1.5 and 3.5 times faster than rates in sulfate solutions, and aqSOA yields in nitrate experiments are twice as high as in sulfate experiments. Nitrate likely promoted the reactions because it is a photolytic source of OH radicals, while sulfate is not, highlighting the importance of aerosol-phase nitrate in the formation of aqSOA by facilitating the photooxidation of organic precursors.
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Contaminantes Atmosféricos , Aerosoles , Sulfato de Amonio , NitratosRESUMEN
Remote sensing devices have been used for decades to measure gaseous emissions from individual vehicles at the roadside. Systems have also been developed that entrain diluted exhaust and can also measure particulate matter (PM) emissions. In 2015, the California Air Resources Board (CARB) reported that 8% of in-field diesel particulate filters (DPF) on heavy-duty (HD) vehicles were malfunctioning and emitted about 70% of total diesel PM emissions from the DPF-equipped fleet. A new high-emitter problem in the heavy-duty vehicle fleet had emerged. Roadside exhaust plume measurements reflect a snapshot of real-world operation, typically lasting several seconds. In order to relate roadside plume measurements to laboratory emission tests, we analyzed carbon dioxide (CO2), oxides of nitrogen (NOX), and PM emissions collected from four HD vehicles during several driving cycles on a chassis dynamometer. We examined the fuel-based emission factors corresponding to possible exceedances of emission standards as a function of vehicle power. Our analysis suggests that a typical HD vehicle will exceed the model year (MY) 2010 emission standards (of 0.2 g NOX/bhp-hr and 0.01 g PM/bhp-hr) by three times when fuel-based emission factors are 9.3 g NOX/kg fuel and 0.11 g PM/kg using the roadside plume measurement approach. Reported limits correspond to 99% confidence levels, which were calculated using the detection uncertainty of emissions analyzers, accuracy of vehicle power calculations, and actual emissions variability of fixed operational parameters. The PM threshold was determined for acceleration events between 0.47 and 1.4 mph/sec only, and the NOX threshold was derived from measurements where after-treatment temperature was above 200°C. Anticipating a growing interest in real-world driving emissions, widespread implementation of roadside exhaust plume measurements as a compliment to in-use vehicle programs may benefit from expanding this analysis to a larger sample of in-use HD vehicles. IMPLICATIONS: Regulatory agencies, civil society, and the public at large have a growing interest in vehicle emission compliance in the real world. Leveraging roadside plume measurements to identify vehicles with malfunctioning emission control systems is emerging as a viable new and useful method to assess in-use performance. This work proposes fuel-based emission factor thresholds for PM and NOx that signify exceedances of emission standards on a work-specific basis by analyzing real-time emissions in the laboratory. These thresholds could be used to prescreen vehicles before roadside enforcement inspection or other inquiry, enhance and further develop emission inventories, and potentially develop new requirements for heavy-duty inspection and maintenance (I/M) programs, including but not limited to identifying vehicles for further testing.
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Contaminantes Atmosféricos/análisis , Dióxido de Carbono/análisis , Monitoreo del Ambiente/métodos , Óxidos de Nitrógeno/análisis , Material Particulado/análisis , Emisiones de Vehículos/análisis , California , Vehículos a MotorRESUMEN
Recent tightening of particulate matter (PM) emission standards for heavy-duty engines has spurred the widespread adoption of diesel particulate filters (DPFs), which need to be regenerated periodically to remove trapped PM. The total impact of DPFs therefore depends not only on their filtering efficiency during normal operation, but also on the emissions during and the frequency of regeneration events. We performed active (parked and driving) and passive regenerations on two heavy-duty diesel vehicles (HDDVs), and report the chemical composition of emissions during these events, as well as the efficiency with which trapped PM is converted to gas-phase products. We also collected activity data from 85 HDDVs to determine how often regeneration occurs during real-world operation. PM emitted during regeneration ranged from 0.2 to 16.3 g, and the average time and distance between real-world active regenerations was 28.0 h and 599 miles. These results indicate that regeneration of real-world DPFs does not substantially offset the reduction of PM by DPFs during normal operation. The broad ranges of regeneration frequency per truck (3-100 h and 23-4078 miles) underscore the challenges in designing engines and associated aftertreatments that reduce emissions for all real-world duty cycles.
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Contaminantes Atmosféricos , Emisiones de Vehículos , Polvo , Vehículos a Motor , Material ParticuladoRESUMEN
BACKGROUND: The combination of peripheral neuropathy and other treatment-associated side effects is likely related to an increased incidence of falls in cancer survivors. The purpose of this study was to quantify differences in postural stability between healthy age-matched controls and cancer survivors. METHODS: Quiet standing under four conditions (eyes open/closed, rigid/compliant surface) was assessed in 34 cancer survivors (2 males, 32 females; age: 54(13) yrs., height: 1.62(0.07) m; mass: 78.5(19.5) kg) and 34 age-matched controls (5 males, 29 females; age: 54(15) yrs.; height: 1.62(0.08) m; mass: 72.8(21.1) kg). Center of pressure data were collected for 30s and the trajectories were analyzed (100Hz). Three-factor (group*surface*vision) mixed model MANOVAs with repeated measures were used to determine the effect of vision and surface on postural steadiness between groups. FINDINGS: Cancer survivors exhibited larger mediolateral root-mean square distance and velocity of the center of pressure, as well as increased 95% confidence ellipse area (P<0.01) when compared with their age-matched counterparts. For example, when removing visual input, cancer survivors had an average increase in 95% confidence ellipse area of 91.8mm2 while standing on a rigid surface compared to a 68.6mm2 increase for the control group. No frequency-based center of pressure measures differed between groups. INTERPRETATION: Cancer survivors exhibit decreased postural steadiness when compared with age-matched controls. For cancer survivors undergoing rehabilitation focused on existing balance deficits, a small subset of the center of pressure measures presented here can be used to track progress throughout the intervention and potentially mitigate fall risk.
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Supervivientes de Cáncer , Equilibrio Postural/fisiología , Postura/fisiología , Anciano , Femenino , Humanos , Masculino , Neoplasias/patologíaRESUMEN
BACKGROUND: People with transtibial amputation stand ~50times/day. There are two general approaches to transtibial amputation: 1) distal tibia and fibula union using a "bone-bridge" (Ertl), 2) non-union of the tibia and fibula (Non-Ertl). The Ertl technique may improve functional outcomes by increasing the end-bearing ability of the residual limb. We hypothesized individuals with an Ertl would perform a five-time sit-to-stand task faster through greater involvement/end-bearing of the affected limb. METHODS: Ertl (n=11) and Non-Ertl (n=7) participants sat on a chair with each foot on separate force plates and performed the five-time sit-to-stand task. A symmetry index (intact vs affected limbs) was calculated using peak ground reaction forces. FINDINGS: The Ertl group performed the task significantly faster (9.33s (2.66) vs 13.27 (2.83)s). Symmetry index (23.33 (23.83)% Ertl, 36.53 (13.51)% Non-Ertl) indicated the intact limb for both groups produced more force than the affected limb. Ertl affected limb peak ground reaction forces were significantly larger than the Non-Ertl affected limb. Peak knee power and net work of the affected limb were smaller than their respective intact limb for both groups. The Ertl intact limb produced significantly greater peak knee power and net work than the Non-Ertl intact knee. INTERPRETATION: Although loading asymmetries existed between the intact and affected limb of both groups, the Ertl group performed the task ~30% faster. This was driven by greater power and work production of the Ertl intact limb knee. Our results suggest that functional differences exist between the procedures.
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Amputación Quirúrgica , Movimiento/fisiología , Postura/fisiología , Tibia , Soporte de Peso/fisiología , Adulto , Amputados , Fenómenos Biomecánicos/fisiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Tibia/cirugíaRESUMEN
Lower extremity joint moment magnitudes during swing are dependent on the inertial properties of the prosthesis and residual limb of individuals with transtibial amputation (TTA). Often, intact limb inertial properties (INTACT) are used for prosthetic limb values in an inverse dynamics model even though these values overestimate the amputated limb's inertial properties. The purpose of this study was to use subject-specific (SPECIFIC) measures of prosthesis inertial properties to generate a general model (GENERAL) for estimating TTA prosthesis inertial properties. Subject-specific mass, center of mass, and moment of inertia were determined for the shank and foot segments of the prosthesis (n=11) using an oscillation technique and reaction board. The GENERAL model was derived from the means of the SPECIFIC model. Mass and segment lengths are required GENERAL model inputs. Comparisons of segment inertial properties and joint moments during walking were made using three inertial models (unique sample; n=9): (1) SPECIFIC, (2) GENERAL, and (3) INTACT. Prosthetic shank inertial properties were significantly smaller with the SPECIFIC and GENERAL model than the INTACT model, but the SPECIFIC and GENERAL model did not statistically differ. Peak knee and hip joint moments during swing were significantly smaller for the SPECIFIC and GENERAL model compared with the INTACT model and were not significantly different between SPECIFIC and GENERAL models. When subject-specific measures are unavailable, using the GENERAL model produces a better estimate of prosthetic side inertial properties resulting in more accurate joint moment measurements for individuals with TTA than the INTACT model.
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Miembros Artificiales , Extremidad Inferior/fisiología , Modelos Biológicos , Adulto , Amputación Quirúrgica , Fenómenos Biomecánicos , Femenino , Articulación de la Cadera/fisiología , Humanos , Articulación de la Rodilla/fisiología , Masculino , Persona de Mediana Edad , Implantación de Prótesis , Caminata/fisiología , Adulto JovenRESUMEN
Gait data are commonly presented as an average of many trials or as an average across participants. Discrete data points (eg, maxima or minima) are identified and used as dependent variables in subsequent statistical analyses. However, the approach used for obtaining average data from multiple trials is inconsistent and unclear in the biomechanics literature. This study compared the statistical outcomes of averaging peaks from multiple trials versus identifying a single peak from an average profile. A series of paired-samples t tests were used to determine whether there were differences in average dependent variables from these 2 methods. Identifying a peak value from the average profile resulted in significantly smaller magnitudes of dependent variables than when peaks from multiple trials were averaged. Disagreement between the 2 methods was due to temporal differences in trial peak locations. Sine curves generated in MATLAB confirmed this misrepresentation of trial peaks in the average profile when a phase shift was introduced. Based on these results, averaging individual trial peaks represents the actual data better than choosing a peak from an average trial profile.
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Interpretación Estadística de Datos , Marcha , Caminata/fisiología , Adulto , Fenómenos Biomecánicos , Femenino , Humanos , Masculino , Adulto JovenRESUMEN
Kinetic and kinematic responses during walking vary by footwear condition. Load carriage also influences gait patterns, but it is unclear how an external load influences barefoot walking. Twelve healthy adults (5 women, 7 men) with no known gait abnormalities participated in this study (age=23±3years, height=1.73±0.11m, and mass=70.90±12.67kg). Ground reaction forces and 3D motion were simultaneously collected during overground walking at 1.5ms-1 in four conditions: Barefoot Unloaded, Shod Unloaded, Barefoot Loaded, and Shod Loaded. Barefoot walking reduced knee and hip joint ranges of motion, as well as stride length, stance time, swing time, and double support time. Load carriage increased stance and double support times. The 15% body weight load increased GRFs â¼15%. Walking barefoot reduced peak anteroposterior GRFs but not peak vertical GRFs. Load carriage increased hip, knee, and ankle joint moments and powers, while walking barefoot increased knee and hip moments and powers. Thus, spatiotemporal and kinematic adjustments to walking barefoot decrease GRFs but increase knee and hip kinetic measures during overground walking. The ankle seems to be less affected by these footwear conditions. Regardless of footwear, loading requires larger GRFs, joint loads, and joint powers.
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Marcha/fisiología , Extremidad Inferior/fisiología , Zapatos , Caminata/fisiología , Soporte de Peso/fisiología , Adulto , Articulación del Tobillo/fisiología , Fenómenos Biomecánicos , Femenino , Articulación de la Cadera/fisiología , Humanos , Cinética , Articulación de la Rodilla/fisiología , Masculino , Adulto JovenRESUMEN
Gait patterns are commonly altered when walking or running barefoot compared to shod conditions. Although controversy exists as to whether barefoot conditions result in lower metabolic costs, it is clear that adding load to the body results in increased metabolic costs. The effects of footwear and backpack loading have been investigated separately, but it is unclear whether manipulating both simultaneously would cause similar outcomes. Twelve healthy individuals (7 female, 5 male) with no obvious gait abnormalities participated in this study (age=24±2 years, height=1.73±0.13 m, and mass=71.1±16.9 kg). Steady state metabolic data and 3D motion capture were collected during treadmill walking at 1.5 ms(-1) in four conditions: Barefoot Unloaded, Shod Unloaded, Barefoot Loaded, and Shod Loaded. Barefoot walking elicited shorter stride lengths, stance and double support times, as well as a slight (≈1%), but not significant, decrease in metabolic cost. Loading increased metabolic costs of walking but did not elicit spatiotemporal changes in either footwear condition. Lower limb kinematic differences were noted in response to both loading and footwear. Changes in spatiotemporal parameters observed when walking barefoot were not exacerbated by the addition of a backpack load. This suggests that the increased metabolic demand associated with the load is met with a similar spatiotemporal pattern whether a person wears a supportive shoe or not. Thus, the discomfort associated with foot strike while barefoot that promotes spatiotemporal changes seems to be independent of load.
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Fenómenos Biomecánicos/fisiología , Metabolismo Energético/fisiología , Marcha/fisiología , Zapatos , Caminata/fisiología , Soporte de Peso/fisiología , Adulto , Prueba de Esfuerzo , Femenino , Humanos , Masculino , Aparatos Ortopédicos , Carrera/fisiología , Adulto JovenRESUMEN
Chemical processing in atmospheric aqueous phases, such as cloud and fog drops, can play a significant role in the production and evolution of secondary organic aerosol (SOA). In this work we examine aqueous SOA production via the oxidation of benzene-diols (dihydroxy-benzenes) by the triplet excited state of 3,4-dimethoxybenzaldehyde, (3)DMB*, and by hydroxyl radical, ËOH. Reactions of the three benzene-diols (catechol (CAT), resorcinol (RES) and hydroquinone (HQ)) with (3)DMB* or ËOH proceed rapidly, with rate constants near diffusion-controlled values. The two oxidants exhibit different behaviors with pH, with rate constants for (3)DMB* increasing as pH decreases from pH 5 to 2, while rate constants with ËOH decrease in more acidic solutions. Mass yields of SOA were near 100% for all three benzene-diols with both oxidants. We also examined the reactivity of atmospherically relevant mixtures of phenols and benzene-diols in the presence of (3)DMB*. We find that the kinetics of phenol and benzene-diol loss, and the production of SOA mass, in mixtures are generally consistent with rate constants determined in experiments containing a single phenol or benzene-diol. Combining our aqueous kinetic and SOA mass yield data with previously published gas-phase data, we estimate a total SOA production rate from benzene-diol oxidation in a foggy area with significant wood combustion to be nearly 0.6 µg mair(-3) h(-1), with approximately half from the aqueous oxidation of resorcinol and hydroquinone, and half from the gas-phase oxidation of catechol.