Novel natural food colourant G8000 benefits LDL- and HDL-cholesterol in humans.

The aim of this study was to investigate the phenolic composition of a natural food colourant (G8000™) as well as its effects on plasma markers after 28-day consumption by healthy individuals at a dietary dose (70 g). Parameters of total cholesterol and its fractions, triglycerides and plasma enzymes biomarkers of muscle injury were measured. Major compounds identified in G8000™ by ESI-MS showed the presence of anthocyanins, organic acids, phenolic acids as well as monosaccharides. HDL levels significantly increased from 43 ± 10.2 mg/dL to 95 ± 16.9 mg/dL. LDL levels significantly decreased from 110 ± 40.9 mg/dL to 69 ± 39 mg/dL (p < 0.001). No significant statistical differences (p > 0.05) were observed for total cholesterol, triglycerides and VLDL. After the intake, plasma enzyme CK-MB decreased from 20 ± 12.1 U/L to 10 ± 1.9 U/L while LDH levels increased from 275 ± 124.4 U/L to 317 ± 114.7 U/L (p < 0.005). No significant differences were observed for CK levels. Taken together, dietary intake of natural colourant G8000™ was able to exert beneficial effects on atherosclerosis biomarkers.

Obstrução e perfuração jejunal e ileal por cálculos advindos de fístula colecistoduodenal: relato de caso / Jejunal and ileal obstruction and perforation by calculus from cholecysto-duodenal fistula: case report

Introdução: íleo biliar é complicação de colecistopatia calculosa devido à comunicação anormal entre a via biliar e o trato gastrintestinal, com migração de um ou mais cálculos de grandes dimensões para os segmentos intestinais. Esse cálculo segue o trajeto intestinal até encontrar um ponto a partir do qual não consegue mais progredir, provocando obstrução. É mais comum a colecistite aguda ser complicada com fístulacolecistoduodenal com migração de cálculo maior que 2 cm para o delgado e sua impactação na válvula ileocecal e obstrução intestinal. É mais prevalente em idosos, acometendo quatro mulheres para cada homem e de mortalidade elevada especialmente pela faixa etária acometida e pelo diagnóstico difícil e tardio. Relato de caso: 57 anos, feminino, com abdome agudo decorrente de colecistite aguda complicada com fístula colecistoduodenal e impactação de dois cálculos biliares com cerca de 3 cm em jejuno e íleo, seguida de obstrução intestinal e perfuração de ambos os segmentos de delgado. Foi realizada enterectomia segmentar de jejuno, retirada dos cálculos por propulsãomanual retrógrada, anastomose primária, desbridamento e rafia da perfuração ileal. Conclusão: o diagnóstico precoce do íleo biliar é relevante, pois se associa a altas taxas de morbidade e mortalidade, sendo seu tratamento eminentemente cirúrgico.

Introduction: Biliary ileum is a complication from the calculus cholecystopathy due to abnormal communication between the biliary via and the gastrintestinal tract, with the migration of one or more huge calculi to the intestinal segments. This calculus follows the intestinal journey until it finds a point where it can no longer progress, causing obstruction. It is more common that the acute cholecystitis be complicated with a cholecysto-duodenal fistula with migration of a calculus higher than 2 cm for the small intestine and its impact on the ileocecal valve and intestinal obstruction. This is more prevalent in aged people, in four women toevery man and with a high mortality mainly for the age range under issue and by the difficult and late diagnosis. Case report: A 57-year-old female with acute abdomen due to a complicated acute cholecystitis with cholecysto-duodenal fistula and impact on two biliary calculi of about 3 cm in the jejune and ileum, followed by intestinal obstruction and perforation of both small intestine segments. Jejunal segmentar enterectomy, withdrawal of calculi by retrograde manual propulsion, primary anastomosis, debridement, and ileal perforation raffia were carried out. Conclusion: Early diagnosis of the biliary ileum is relevant because it is associated with high morbidity and mortality rates, and its treatment should be surgical.